Chromenopyridin A, a new N-methoxy-1-pyridone alkaloid from the endophytic fungus Penicillium nothofagi P-6 isolated from the critically endangered conifer Abies beshanzuensis

Zhu, Yuan-Xing; Peng, Cheng; Ding, Wenxin; Hu, Jin‐Feng; Li, Jiyang

doi:10.1080/14786419.2020.1844700

Cited by 10 publications

(6 citation statements)

References 16 publications

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“…A novel N-methoxy-1-pyridone alkaloid, chromenopyridin A (229), and the already reported compound viridicatol (230, Figure 13) were purified from Penicillium nothofagi P-6, residing inside the bark of Abies beshanzuensis. Compounds 229 and 230 exhibited antibacterial activity against S. aureus, with MIC values of 62.5 and 15.6 µg/mL, respectively [112].…”

Section: Penicilliummentioning

confidence: 99%

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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Antibiotic resistance is becoming a burning issue due to the frequent use of antibiotics for curing common bacterial infections, indicating that we are running out of effective antibiotics. This has been more obvious during recent corona pandemics. Similarly, enhancement of antimicrobial resistance (AMR) is strengthening the pathogenicity and virulence of infectious microbes. Endophytes have shown expression of various new many bioactive compounds with significant biological activities. Specifically, in endophytic fungi, bioactive metabolites with unique skeletons have been identified which could be helpful in the prevention of increasing antimicrobial resistance. The major classes of metabolites reported include anthraquinone, sesquiterpenoid, chromone, xanthone, phenols, quinones, quinolone, piperazine, coumarins and cyclic peptides. In the present review, we reported 451 bioactive metabolites isolated from various groups of endophytic fungi from January 2015 to April 2021 along with their antibacterial profiling, chemical structures and mode of action. In addition, we also discussed various methods including epigenetic modifications, co-culture, and OSMAC to induce silent gene clusters for the production of noble bioactive compounds in endophytic fungi.

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Section: Penicilliummentioning

confidence: 99%

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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“…11 c ,12 The plant sample of A. beshanzuensis is too precious but extremely limited to be collected on a large scale for further phytochemical investigation, we thereafter turned to its endophytic fungi. 13 This conifer (growing up in a special environmental setting) is still very attractive and promising, blow people away. It encouraged us to carry out a further research of its endophytic fungus.…”

Section: Introductionmentioning

confidence: 99%

Beshanzoides A–D, unprecedented cycloheptanone-containing polyketides from Penicillium commune P-4-1, an endophytic fungus of the endangered conifer Abies beshanzuensis

Chen

Jiang

et al. 2021

RSC Adv.

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“…MGF222. 409 Ergosterdiacids A and B ( 1132 and 1133 ) were two unusual naturally Diels–Alder additive steroids, constructing a 6/6/6/6/5 pentacyclic steroidal system 403 and exhibited potential in vitro inhibition activity against MptpB with IC 50 value of 15.1 and 30.1 μM, respectively. 403 The inhibitory kinetic experiments indicated that both of them acted via a noncompetitive inhibition mechanism.…”

Section: Secondary Metabolites From Mangrove Fungimentioning

confidence: 99%