Chromium Exposure and Risk of Cardiovascular Disease in High Cardiovascular Risk Subjects　― Nested Case-Control Study in the Prevention With Mediterranean Diet (PREDIMED) Study ―

Gutiérrez‐Bedmar, Mario; Martínez‐González, Miguel Ángel; Muñoz-Bravo, Carlos; Ruiz‐Canela, Miguel; Mariscal, Alberto; Salas‐Salvadó, Jordi; Estruch, Ramón; Corella, Dolores; Arós, Fernando; Fitó, Montserrat; Lapetra, José; Serra‐Majem, Lluís; Pintó, Xavier; Alonso‐Gómez, Ángel M.; Portolés, Olga; Fiol, Miquel; Bulló, Mònica; Castañer, Olga; Ros, Emilio; Gómez‐Gracia, Enrique

doi:10.1253/circj.cj-17-0032

Cited by 13 publications

(5 citation statements)

References 34 publications

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“…In other works, blood and scalp hair Cr was found at lower levels of myocardial infraction patients than the controls, which was attributed to the increased urinary loss of this element [ 101 ]. The possible protective role of Cr against CVD was indicated as in a case-control study conducted involving CVD patients, where the toenail Cr levels were higher for the control participants [ 102 ].…”

Section: Resultsmentioning

confidence: 99%

Heart Failure and PAHs, OHPAHs, and Trace Elements Levels in Human Serum: Results from a Preliminary Pilot Study in Greek Population and the Possible Impact of Air Pollution

et al. 2021

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Cardiovascular diseases (CVDs) have been associated with environmental pollutants. The scope of this study is to assess any potential relation of polycyclic aromatic hydrocarbons (PAHs), their hydroxylated derivatives, and trace elements with heart failure via their direct determination in human serum of Greek citizens residing in different areas. Therefore, we analyzed 131 samples including cases (heart failure patients) and controls (healthy donors), and the respective demographic data were collected. Significantly higher concentrations (p < 0.05) were observed in cases’ serum regarding most of the examined PAHs and their derivatives with phenanthrene, fluorene, and fluoranthene being the most abundant (median of >50 μg L−1). Among the examined trace elements, As, Cd, Cu, Hg, Ni, and Pb were measured at statistically higher concentrations (p < 0.05) in cases’ samples, with only Cr being significantly higher in controls. The potential impact of environmental factors such as smoking and area of residence has been evaluated. Specific PAHs and trace elements could be possibly related with heart failure development. Atmospheric degradation and smoking habit appeared to have a significant impact on the analytes’ serum concentrations. PCA–logistic regression analysis could possibly reveal common mechanisms among the analytes enhancing the hypothesis that they may pose a significant risk for CVD development.

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Section: Resultsmentioning

confidence: 99%

Heart Failure and PAHs, OHPAHs, and Trace Elements Levels in Human Serum: Results from a Preliminary Pilot Study in Greek Population and the Possible Impact of Air Pollution

et al. 2021

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“…Several epidemiological findings have confirmed that Cr (III) supplementation helps to improve CVD. 94,99–101 Overall, the results of several studies have shown the positive role of Cr (III) supplementation in carbohydrate and lipid metabolism, 102 blood pressure changes, 103 the levels of oxidative stress markers, 104 and inflammatory indices. 101…”

Section: Classification Of Heavy Metals and Cardiovascular Hazardsmentioning

confidence: 98%

“…98 Several epidemiological findings have confirmed that Cr (III) supplementation helps to improve CVD. 94,[99][100][101] Overall, the results of several studies have shown the positive role of Cr (III) supplementation in carbohydrate and lipid metabolism, 102 blood pressure changes, 103 the levels of oxidative stress markers, 104 and inflammatory indices. 101 However, Cr (VI) exerts opposing effects to those of Cr (III) and can induce oxidative stress, chronic inflammation, endothelial dysfunction, cell death, genetic development, and instability.…”

Section: Compendium On Environmental Impacts On Cardiovascular Health...mentioning

confidence: 98%

Heavy Metal Exposure and Cardiovascular Disease

Pan,

Gong,

Liang

2024

Circulation Research

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Heavy metals are harmful environmental pollutants that have attracted widespread attention due to their health hazards to human cardiovascular disease. Heavy metals, including lead, cadmium, mercury, arsenic, and chromium, are found in various sources such as air, water, soil, food, and industrial products. Recent research strongly suggests a connection between cardiovascular disease and exposure to toxic heavy metals. Epidemiological, basic, and clinical studies have revealed that heavy metals can promote the production of reactive oxygen species, which can then exacerbate reactive oxygen species generation and induce inflammation, resulting in endothelial dysfunction, lipid metabolism distribution, disruption of ion homeostasis, and epigenetic changes. Over time, heavy metal exposure eventually results in an increased risk of hypertension, arrhythmia, and atherosclerosis. Strengthening public health prevention and the application of chelation or antioxidants, such as vitamins and beta-carotene, along with minerals, such as selenium and zinc, can diminish the burden of cardiovascular disease attributable to metal exposure.

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“… Cancers of vital organs like prostate, urinary bladder, breast, and liver [43] . Chromium Increased risk of CVDs [49] . Sneezing, watery nasal discharge, labored breathing, choking sensation in the throat, asthma and other respiratory distresses like chronic bronchitis, chronic irritation, chronic pharyngitis, and chronic rhinitis [50] , [51] .…”

Section: Common Molecular Mechanisms Of Heavy Metal Toxicitymentioning

confidence: 99%

Disease-associated metabolic pathways affected by heavy metals and metalloid

Haidar¹,

Fatema²,

Shoily³

et al. 2023

Toxicology Reports

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Chromium Exposure and Risk of Cardiovascular Disease in High Cardiovascular Risk Subjects　― Nested Case-Control Study in the Prevention With Mediterranean Diet (PREDIMED) Study ―

Cited by 13 publications

References 34 publications

Heart Failure and PAHs, OHPAHs, and Trace Elements Levels in Human Serum: Results from a Preliminary Pilot Study in Greek Population and the Possible Impact of Air Pollution

Heart Failure and PAHs, OHPAHs, and Trace Elements Levels in Human Serum: Results from a Preliminary Pilot Study in Greek Population and the Possible Impact of Air Pollution

Heavy Metal Exposure and Cardiovascular Disease

Disease-associated metabolic pathways affected by heavy metals and metalloid

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Chromium Exposure and Risk of Cardiovascular Disease in High Cardiovascular Risk Subjects ― Nested Case-Control Study in the Prevention With Mediterranean Diet (PREDIMED) Study ―

Cited by 13 publications

References 34 publications

Heart Failure and PAHs, OHPAHs, and Trace Elements Levels in Human Serum: Results from a Preliminary Pilot Study in Greek Population and the Possible Impact of Air Pollution

Heart Failure and PAHs, OHPAHs, and Trace Elements Levels in Human Serum: Results from a Preliminary Pilot Study in Greek Population and the Possible Impact of Air Pollution

Heavy Metal Exposure and Cardiovascular Disease

Disease-associated metabolic pathways affected by heavy metals and metalloid

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Product

Resources

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Chromium Exposure and Risk of Cardiovascular Disease in High Cardiovascular Risk Subjects　― Nested Case-Control Study in the Prevention With Mediterranean Diet (PREDIMED) Study ―