Chromium-Picolinate Therapy in Diabetes Care: Individual Outcomes Require New Guidelines and Navigation by Predictive Diagnostics

Abstract

Aims Nephropathy is the leading secondary complication of metabolic syndrome. Nutritional supplement by chromium-picolinate is assumed to have renoprotective effects. However, potential toxic effects reported increase concerns about safety of chromium-picolinate. The experimental design aimed at determining, whether the treatment with clinically relevant doses of chromium-picolinate can harm individual oucomes through DNA damage and extensive alterations in central detoxification / cell-cycle regulating pathways in treatment of diabetes. Methods The study was performed in a double-blind manner. Well-acknowledged animal model of db/db-mice and clinically relevant doses of chromium-picolinate were used. As an index of DNA-damage, measurement of DNA-breaks was performed using “Comet Assay”-analysis. Individual and group-specific expression patterns of SOD-1 and P53 were evaluated to get insights into central detoxification and cell-cycle regulating pathways under treatment conditions. Results Experimental data revealed highly individual reaction under treatment conditions. Highest variability of DNA-damage was monitored under prolonged treatment with high dosage of CrPic. Expression patterns demonstrated a correlation with subcellular imaging and dosage-dependent suppression under chromium-picolinate treatment. Interpretation and recommendations Population at-risk for diabetes is huge and increasing in pandemic scale. One of the reasons might be the failed attempt to prevent the disease by application of artificial supplements and drugs with hardly recognised individual risks. Consequently, a multimodal approach of integrative medicine by predictive diagnostics, targeted prevention and individually created treatment algorithms is highly desirable.

Formulation and Stability Evaluation of Anti-Obesity Nutraceuitcal Blend of White Kidney Bean Extract (Phaseolus Vulgaris L.), Propolis Ethanolic Extract and Crpic3

“…Similarly, our findings regarding the stability of chromium picolinate as judged from the level of chromium, demonstrated it to be stable for the whole period of the study in the three dosage forms under the accelerated stability study conditions. This finding agreed with multiple previous studies that showed that chromium-picolinate is a highly stable molecule with an over 95% recovery under forced degradation [68,69].…”

Biotin and chromium histidinate improve glucose metabolism and proteins expression levels of IRS-1, PPAR-γ, and NF-κB in exercise-trained rats

“…The beneficial effect of exercise on the risk of metabolic diseases may be due to the improvement in glucose and insulin sensitivities, inflammatory markers and blood lipids level [ 46 , 47 ]. Exercise combined with micronutrient supplementation such as CrHis and biotin are efficient in preventing or treating various metabolic diseases [ 48 , 49 ]. Chromium (Cr) is an essential trace element particularly involved in carbohydrate, fat, and protein metabolism [ 27 , 50 ].…”

Effect of chromium supplementation on glycated hemoglobin and fasting plasma glucose in patients with diabetes mellitus

“…Type 2 diabetes mellitus (T2DM) is the most prevalent form of diabetes worldwide [ 1 , 2 ]. It is characterized by defects in pancreatic insulin secretion or action causing hyperglycemia attributable to disturbances in carbohydrate, fat and lipid metabolism [ 1 ]. The worldwide prevalence of T2DM is increasing and more than 366 million people are expected to be affected by the year 2030 [ 2 ].…”