Chromoblastomycosis due to Fonsecaea monophora misdiagnosed as sporotrichosis and cutaneous tuberculosis in a pulmonary tuberculosis patient

Abstract

Chromoblastomycosis is caused by dematiaceous fungi. It develops after inoculation of the organism into the skin. We report a case of chromoblastomycosis in a pulmonary tuberculosis patient without known history of trauma. The lesions were initially diagnosed as sporotrichosis and skin tuberculosis. Histopathology of scales and skin biopsy specimen revealed sclerotic bodies, the hallmark of chromoblastomycosis. The causative organism was identified as Fonsecaea monophora by rDNA ITS sequencing. The lesions recovered markedly after two month treatment with oral terbinafine 250 mg daily according to drug sensitive test in vitro in combination with local thermotherapy

Study on the organization of cellular elements in the granulomatous lesion caused by chromoblastomycosis

“…CB is one of the most frequent fungal infection that develops after inoculation of the organism into the skin constituting a subcutaneous, chronic, granulomatous mycosis and some patients can develop a squamous cell carcinoma in older lesions . Immunocompetent patients can develop CB, but the immunocompromised individuals with a long‐term treatment of corticosteroids and immunosuppressive agents can develop lesions whose skin biopsy can show numerous brown muriform cells and septate hyphae in the tissue …”