Chromoblastomycosis Treated With Local Infiltration of Amphotericin B Solution

DeFeo, Charles P.

doi:10.1001/jama.1959.03010320051012

Cited by 12 publications

(11 citation statements)

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“…The present study confirmed the effectiveness of IL amphotericin B as previously reported 22,23,25,26,29 . Treatment abandonment was due to non‐compliance by owners.…”

Section: Discussionsupporting

confidence: 89%

“…Local infiltration of amphotericin B has been described for the treatment of human patients with localised fungal infections such as chromoblastomycosis, 22‐27 alternariosis 28,29 and sporotrichosis 30 as well as for the treatment of a horse with conidiobolomycosis 31 . This route of administration is associated with high tissue concentrations, tissue conservation and few adverse systemic consequences 24,26,27 .…”

Section: Discussionmentioning

confidence: 99%

“…However, in the latter case the infiltrated areas became purulent after therapy. In the present study, we used a concentration of 5 mg/mL, as reported in other studies 22,23,26,30 …”

Section: Discussionmentioning

confidence: 99%

“…Only one cat had a prolonged anaesthetic recovery, presumably due to acepromazine. Some investigators performed applications twice weekly, weekly, or every other week 22,23,25,26 . In one study, 22 the frequency of these injections was determined by the discomfort caused by the injection and the healing delay of the chromoblastomycotic lesion after each injection.…”

Section: Discussionmentioning

confidence: 99%

“…Injection of amphotericin B may cause a slight elevation of temperature and anorexia, 23 and Costello et al 22 . observed a systemic reaction characterised by chills and mild lymph node enlargement when an overdose of 40 mg amphotericin B was inadvertently injected.…”

Section: Discussionmentioning

confidence: 99%

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Treatment of refractory feline sporotrichosis with a combination of intralesional amphotericin B and oral itraconazole

et al. 2011

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OBJECTIVE To describe the use of intralesional amphotericin B in localised lesions for the treatment of 26 cats from Rio de Janeiro, Brazil, with sporotrichosis refractory to oral itraconazole. DESIGN Uncontrolled intervention study. METHOD The 26 cats in this study were diagnosed with sporotrichosis, confirmed by isolation of Sporothrix schenckii, and presented residual localised skin lesions refractory to treatment with oral itraconazole for a minimum period of 8 weeks. The animals received weekly applications of intralesional amphotericin B in conjunction with oral itraconazole. In cases of owner unavailability, a maximum of 2 weeks between the infiltrations was accepted. RESULTS Twenty-two (84.6%) of the 26 treated cats achieved clinical remission, 16 (72.7%) of which were cured, and in the remaining six (27.3%) the lesions recurred at the same site. Lack of clinical response was observed in one animal and three owners abandoned treatment. CONCLUSION The proposed therapeutic regimen is an adjunctive treatment option for cats with sporotrichosis presenting as residual skin lesions refractory to itraconazole.

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“…The present study confirmed the effectiveness of IL amphotericin B as previously reported 22,23,25,26,29 . Treatment abandonment was due to non‐compliance by owners.…”

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

“…However, in the latter case the infiltrated areas became purulent after therapy. In the present study, we used a concentration of 5 mg/mL, as reported in other studies 22,23,26,30 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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