Chromoendoscopy Using Indigo Carmine Dye Spraying with Magnifying Observation Is the Most Reliable Method for Differential Diagnosis between Non-Neoplastic and Neoplastic Colorectal Lesions: A Prospective Study

Fu, Kuang I.; Sano, Yasushi; Kato, Shigeharu; Fujii, Takeshi; Nagashima, Fumio; Yoshino, Takayuki; Okuno, Toshio; Yoshida, Shigeto; Fujimori, Takahiro

doi:10.1055/s-2004-826039

Cited by 234 publications

(173 citation statements)

References 6 publications

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“…The diagnostic accuracy with the different techniques in our study was lower than in some other series [2,5,[13][14][15][16] . Possible explanations for such differences are that some series included larger polyps, which are probably easier to diagnose [5,[13][14][15] , or that diagnosis was estimated with a live video-endoscopy image and not with stored [2,13] , which could enable a more exact diagnosis.…”

Section: Discussioncontrasting

confidence: 50%

“…Possible explanations for such differences are that some series included larger polyps, which are probably easier to diagnose [5,[13][14][15] , or that diagnosis was estimated with a live video-endoscopy image and not with stored [2,13] , which could enable a more exact diagnosis. Some series used absorptive stains, which can be more accurate [13,14] .…”

Section: Discussionmentioning

confidence: 99%

“…However, this study did not compare the views obtained using different FICE settings and did not comment on the capabilities in the presence of suboptimal bowel cleansing or after the application of indigo carmine dye. Our study aimed to: (1) systematically compare the 10 pre-set FICE settings with normal white light and indigo carmine dye in terms of their ability to enhance views of normal mucosa and polyps, (2) assess FICE in the presence of suboptimal bowel preparation, (3) determine whether poor bowel preparation markedly degrades the capabilities of "virtual chromoendoscopy" systems [10] .…”

Section: Introductionmentioning

confidence: 99%

“…Indigo carmine (IC) can be used with conventional endoscopy [1] or with magnifying colonoscopy [2][3][4][5] . Endoscopy manufacturers have developed artificial image enhancements, including "virtual chromoendoscopy", as a quicker and less messy alternative to dye spraying.…”

Section: Introductionmentioning

confidence: 99%

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Validation of Fujinon intelligent chromoendoscopy withhigh defnition endoscopes in colonoscopy

Parra‐Blanco¹,

Jiménez²,

Rembacken³

et al. 2009

WJG

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AIM:To validate high definition endoscopes with Fujinon intelligent chromoendoscopy (FICE) in colonoscopy. METHODS:The image quality of normal white light endoscopy (WLE), that of the 10 available FICE filters and that of a gold standard (0.2% indigo carmine dye) were compared. RESULTS:FICE-filter 4 [red, green, and blue (RGB) wavelengths of 520, 500, and 405 nm, respectively] provided the best images for evaluating the vascular pattern compared to white light. The mucosal surface was best assessed using filter 4. However, the views obtained were not rated significantly better than those observed with white light. The "gold standard", indigo carmine (IC) dye, was found to be superior to both white light and filter 4. Filter 6 (RGB wavelengths of 580, 520, and 460 nm, respectively) allowed for exploration of the IC-stained mucosa. When assessing mucosal polyps, both FICE with magnification, and magnification following dye spraying were superior to the same techniques without magnification and to white light imaging. In the presence of suboptimal bowel preparation, observation with the FICE mode was possible, and endoscopists considered it to be superior to observation with white light. CONCLUSION:FICE-filter 4 with magnification improves the image quality of the colonic vascular patterns obtained with WLE.

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Section: Discussioncontrasting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Validation of Fujinon intelligent chromoendoscopy withhigh defnition endoscopes in colonoscopy

Parra‐Blanco¹,

Jiménez²,

Rembacken³

et al. 2009

WJG

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show abstract

“…Previously, chromoendoscopy with dye-spraying, which provides a more detailed visualization of the mucosa by enhancing its morphology, was developed to improve upon the accuracy afforded by conventional endoscopy (7)(8)(9). The authors of the present study (10,11) and other studies (12)(13)(14)(15)(16) have previously demonstrated that this imaging technique facilitates the detection of early-stage neoplastic lesions in UC.…”

Section: Introductionmentioning

confidence: 85%

Stereomicroscopic features of colitis-associated tumors in mice: Evaluation of pit pattern

et al. 2017

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Abstract.Patients with longstanding ulcerative colitis have an increased risk of colorectal cancer. Mouse models for colitis-associated tumors are indispensable for the development of novel strategies for prevention and intervention, as well as an improved understanding of the mechanisms underlying tumor formation. The present study examined whether stereomicroscopic observations with dye-application were able to detect and discriminate tumors in a colitis-associated tumor model in mice. Colonic tumors were induced in C57BL/6 mice by 15 cycles of treatment with dextran sulfate sodium (DSS) in drinking water. The mice were then divided into 4 groups: normal mice fed a control diet, normal mice fed an iron-supplemented diet, 0.7% DSS mice fed an iron diet and 1.5% DSS mice fed an iron diet. The entire colons were characterized with respect to both morphology and histology. The pit pattern architecture was analyzed using stereomicroscopy with dye agents (0.2% indigo carmine or 0.06% crystal violet). The tumor histology was graded as negative, indefinite or positive for dysplasia. The positive category was divided into two subcategories: low-grade dysplasia (LGD) and high-grade dysplasia (HGD). The tumor incidences and multiplicity were significantly higher in mice fed an iron diet and 1.5% DSS compared with in mice fed an iron diet and 0.7% DSS. Compared with LGD, HGD was predominantly located in the distal colon, was larger in size and had a higher incidence of elevated lesions (Is and IIa) and a lower incidence of flat lesions (IIb). In regards to the pit pattern, HGD had a high incidence of V I pits and a low incidence of IV, III L and II pits. In conclusion, evaluation of the pit pattern using stereomicroscopy with dye-application is useful for detecting and discriminating neoplastic changes in DSS mice and may further our understanding of the mechanisms that induce tumor formation in patients with ulcerative colitis and the characterization of pharmaceutical responses. IntroductionUlcerative colitis (UC) is a chronic relapsing disorder associated with uncontrolled inflammation within the gastrointestinal tract (1). Patients with longstanding UC have an increased risk of colorectal cancer (2,3). The molecular pathway that induces cancer in UC appears to differ from the well-known 'adenoma-carcinoma sequence', as these types of cancer often develop in flat or mildly elevated lesions and are distributed multifocally within an area of intestinal inflammation, called the 'inflammation-dysplasia-carcinoma sequence' (4-6). Therefore, the timely colonoscopic detection and diagnosis of neoplasia during early phase is crucially important for treatment.Previously, chromoendoscopy with dye-spraying, which provides a more detailed visualization of the mucosa by enhancing its morphology, was developed to improve upon the accuracy afforded by conventional endoscopy (7-9). The authors of the present study (10,11) and other studies (12)(13)(14)(15)(16) have previously demonstrated that this imaging technique facilitates the de...

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Optical Chromoendoscopy using NBI During Screening Colonoscopy: Its Usefulness and Application

Sano¹,

Yoshida²

2007

Comprehensive Atlas of High Resolution Endoscopy and Narrow Band Imaging

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Chromoendoscopy Using Indigo Carmine Dye Spraying with Magnifying Observation Is the Most Reliable Method for Differential Diagnosis between Non-Neoplastic and Neoplastic Colorectal Lesions: A Prospective Study

Abstract: Chromoendoscopy with magnification is the most reliable method for determining whether a colorectal lesion is non-neoplastic or neoplastic.

Cited by 234 publications

References 6 publications

Validation of Fujinon intelligent chromoendoscopy withhigh defnition endoscopes in colonoscopy

Validation of Fujinon intelligent chromoendoscopy withhigh defnition endoscopes in colonoscopy

Stereomicroscopic features of colitis-associated tumors in mice: Evaluation of pit pattern

Optical Chromoendoscopy using NBI During Screening Colonoscopy: Its Usefulness and Application

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