Chromoendoscopy versus autofluorescence imaging for neoplasia detection in patients with longstanding ulcerative colitis (FIND-UC): an international, multicentre, randomised controlled trial

Vleugels, Jasper L A; Rutter, Matt; Ragunath, Krish; Rees, Colin; Ponsioen, Cyriel Y.; Lahiff, Conor; Ket, Shara; Wanders, Linda K; Samuel, Sunil; Butt, Faheem; Kuiper, Teaco; Travis, Simon; D’Haens, Geert; Wang, Lai M; Eeden, Susanne van; East, James E.; Dekker, Evelien

doi:10.1016/s2468-1253(18)30055-4

Cited by 36 publications

(30 citation statements)

References 46 publications

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“…The search retrieved 565 citations (Figure ). Twenty‐one trials involving 2889 participants with IBD were eligible for inclusion in the review . We could not extract data from three crossover trials because results at the end of the first phase of the study were not reported.…”

Section: Resultsmentioning

confidence: 99%

“…We could not extract data from three crossover trials because results at the end of the first phase of the study were not reported. Thus, 18 trials involving 2638 participants were included in our analysis . Table S2 shows the study design, interventions and population characteristics in the 21 trials included in the review.…”

Section: Resultsmentioning

confidence: 99%

“…In nine of 21 included trials, a total of 125 participants were excluded after randomisation for insufficient bowel preparation, active colonic inflammation, short disease duration or lack of compliance with the study protocol. Fourteen trials included only participants with ulcerative colitis, six trials enrolled participants with both ulcerative colitis and Crohn's disease, and one trial included participants with ulcerative colitis, Crohn's disease and unclassified colitis …”

Section: Resultsmentioning

confidence: 99%

“…Full spectrum high definition white‐light endoscopy has additional lateral camera lenses, providing a 330 degree field of view as opposed to the 170 degree field of view of conventional forward‐viewing endoscopes . We received additional unpublished information from the authors of two trials …”

Section: Resultsmentioning

confidence: 99%

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Systematic review with network meta‐analysis: endoscopic techniques for dysplasia surveillance in inflammatory bowel disease

Iannone

Ruospo²,

Palmer

et al. 2019

Aliment Pharmacol Ther

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Summary Background International guidelines recommend dysplasia surveillance in IBD. Aim To compare endoscopic techniques for dysplasia surveillance Methods We searched MEDLINE, Embase, CENTRAL for randomised trials through May 2019. We estimated odds ratios (ORs) for binary and mean differences (MDs) for continuous outcomes, using frequentist random‐effects network meta‐analysis. We assessed study risk of bias and appraised evidence certainty using GRADE. Results Eighteen trials (2638 participants) were included. Standard definition white‐light endoscopy (OR 0.44, 95% CI 0.26‐0.73; high certainty) and i‐SCAN (OR 0.47, 95% CI 0.25‐0.90; moderate certainty) had lower odds of detecting neoplasia than chromoendoscopy. Fujinon intelligent colour enhancement (FICE), standard definition white‐light endoscopy and i‐SCAN had lower odds for this outcome than full spectrum high definition white‐light endoscopy (ORs 0.02 to 0.15; low certainty). Standard definition white‐light endoscopy had lower odds of detecting nonpolypoid neoplasia than full spectrum high definition white‐light endoscopy, narrow band imaging, chromoendoscopy and high definition white‐light endoscopy (ORs 0.01‐0.14; moderate certainty). Full spectrum high definition white‐light endoscopy ranked as the best technique for both outcomes (moderate certainty). Standard definition white‐light endoscopy had lower odds of detecting neoplasia by target biopsy (OR 0.27, 95% CI 0.08‐0.91) and had shorter procedure time (MD −14.81 minutes, 95% CI −25.03, −4.06) than chromoendoscopy (moderate certainty). Conclusions Chromoendoscopy, high definition white‐light endoscopy, narrow band imaging, autofluorescence, FICE and full spectrum high definition white‐light endoscopy may be comparable for dysplasia surveillance. Standard definition white‐light endoscopy and i‐SCAN probably provide lower yields for neoplasia identification. Full spectrum high definition white‐light endoscopy may represent the first‐line approach.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Systematic review with network meta‐analysis: endoscopic techniques for dysplasia surveillance in inflammatory bowel disease

Iannone

Ruospo²,

Palmer

et al. 2019

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

“…The study is welcome in that direct RCT comparisons of endoscopic devices are rare in endoscopic research but are a superior method to network metanalysis and should increasingly be the gold‐standard method by which we assess novel technology in endoscopy …”

Section: Published Parallel Group Randomized Controlled Trials Involvmentioning

confidence: 99%