Chromosomal aberration frequencies determined by conventional methods: Parallel increases over time in the region of a petrochemical industry and throughout the Czech Republic

Šrám, Radìm J.; Rössner, Pavel; Beskid, Olena; Bavorová, H; Očadlíková, Dana; Solanský, Ivo; Albertini, Richard J.

doi:10.1016/j.cbi.2006.09.008

Cited by 9 publications

(5 citation statements)

References 18 publications

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“…A comparison of the frequency of chromosomal aberrations in the blood of the surveyed residents of North Ossetia and literature data shows that the average frequency of aberrant metaphases in our region is higher than similar data of other authors [13][14][15]. According to [12], the average value of the frequency of aberrant metaphases in the group of basic control from the number of inhabitants of the European part of Russia and CIS countries is 2.13 ± 0.09%, which is lower than in our region (2.75 ± 0.09).…”

Section: Resultssupporting

confidence: 48%

Residents of Industrial Regions: Long Term Dynamics of Spontaneous Mutagenesis

Chshieva¹

2016

Science Evolution

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The studies shows results of the 10-years research related to the frequency of chromosome aberrations in peripheral blood lymphocytes of North Ossetia inhabitants. The study of cytogenetic indexes in the blood of healthy individuals showed an increase in the average frequency of chromosome aberrations as time passed. The long-term cytogenetic study of North Ossetia residents’ blood showed the growth of medium frequency of aberrant metaphases from 2.07 ± 0.37 to 3.04 ± 0.16 in the group of adults and from 0.5 ± 0.25 to 1.9 ± 0.2 in the groups of children. The most significant increase among all studied cytogenetic indexes in groups of North Ossetia adults and children was in 2009 due to accidental release at one of the metallurgical enterprises in the capital city. All studied groups were characterized by prevailed acentric fragments among chromosome disorders, with an increase of all types of aberrations as time passed. There was a growth in the proportion of chromosome aberrations (adults had an increase of double fragments from 0.20 ± 0.11 to 0.60 ± 0.15 and chromosome exchanges from 0.27 ± 0.15 to 0.64 ± 0.13, children: from 0.13 ± 0.13 to 0.26 ± 0.12 and from 0 to 0.26 ± 0.20 respectively). Sex and smoking factors had no significant effect on the studied samples during the observation period. The 10-year (2002-2011) dynamics analysis of cytogenetic disorders has shown an intensification of mutagenic effects on residents of the republic, which were the most severe after accidental releases in 2009. The results of cytogenetic studies suggest that a mutagenic impact of chemical and radioactive nature takes place.

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Section: Resultssupporting

confidence: 48%

Residents of Industrial Regions: Long Term Dynamics of Spontaneous Mutagenesis

Chshieva¹

2016

Science Evolution

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“…Cytogenetic analyses have become the gold standard in epidemiological studies for determining exposure to carcinogenic or mutagenic substances in the work environment. Chromosomal aberrations are one of the most important biomarkers for monitoring initiation of exposure and the development of carcinogenicity (12,13). An increased incidence of chromosomal aberrations in peripheral blood lymphocytes is associated with an increased cancer risk.…”

Section: Introductionmentioning

confidence: 99%

Cytogenetic analysis of coke oven workers in Eastern Slovakia

Sedlák,

Bujňák,

Gajdoš

et al. 2023

Cent Eur J Public Health

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Objective: Our study aimed to evaluate the extent of polycyclic aromatic hydrocarbon (PAH) exposure in coke oven workers from Eastern Slovakia by cytogenetic analysis of human peripheral lymphocytes.Methods: A total of 81 peripheral blood samples were collected from PAH-exposed workers (mean age 45.84 ± 9.73 years) and 30 samples constituted the control group (41.93 ± 15.39 years). The samples were processed using routine cytological analysis. Conventional cytogenetic analysis of human peripheral lymphocytes has been used to evaluate the effects of PAHs.Results: Comparison of the aberrant cells in the total exposed with the controls showed a significant difference (p < 0.05). A high level of significance (p < 0.001) was observed when comparing the gaps between the exposed group and the control group. There was a significant difference (p < 0.01) in aberrant cells and chromatid breaks (p < 0.05) in the GR1 working subgroup compared with the control group. The results of the correlation analysis did not show a significant relationship between the length of occupational exposure and the frequency of aberrant cells (r = 0.071, p = 0.529). Similarly, no association was observed between smoking among coke plant workers and the frequency of aberrant cells (r = 0.117, p = 0.538).Conclusion: Cytogenetic analysis showed an increased frequency of chromosomal aberrations in coke oven workers in Eastern Slovakia.

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“…LBL assembly method provides a unique opportunity to include various functional and responsive components of the layers together. In the case of lactoferrin, the following functions are important: a) protection from enzyme (pepsin); b) protection from low pH (~ 1.4); and b) targeted delivery to the mucosa of the small intestine or the gutassociated lymphoid tissue [15].…”

Section: Introductionmentioning

confidence: 99%

Materials Selection for Production of Microspheres Protecting Lactoferrin Under Acid Conditions

Новоселова¹,

Prosekov²

2016

Science Evolution

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Lactoferrin is a multifunctional protein of the transferrin family, which can be found in the human and other mammals milk. On the basis of many biological functions of lactoferrin, researchers have considered various possibilities of its application in health care, in the prevention and treatment of infectious and inflammatory diseases. However, lactoferrin is exposed to pepsin degradation in the gastrointestinal tract, decreasing its bioactivity after oral administration. In this regard, appropriate delivery system of lactoferrin, which ensures its delivery intact to the receptors in the small intestine requires. In this study, the different compositions of the capsules in combination with tannic acid, formed mainly by hydrogen and hydrophobic interactions were showed. Its stability toward acidic conditions (0.1 M HCl) was investigated. Complexes with polyelectrolytes (and its pairs): PSS/PAH, Parg as the first adsorbed layer on CaCO3 particles formed by electrostatic interactions were presented. As the results, the adsorption of these polyelectrolytes led to greater stability of the obtained capsules. Bovine serum albumin and tannic acid, in particular with the use of poly-L-arginine as the first layer, increasing the stability of the obtained microspheres were selected as the most promising materials for the microcapsules synthesis. The changes in the morphology of [BSA/TA] and Parg [BSA/TA] capsules depending on the various number of bilayers (from 3 to 6) were analyzes. The thickness of capsule was increased on 1-2 nm by applying each subsequent layer. It was noted BSA/TA capsules looked thinner than Parg [BSA/TA] capsules with the same number of bilayers.

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Chromosomal aberration frequencies determined by conventional methods: Parallel increases over time in the region of a petrochemical industry and throughout the Czech Republic

Cited by 9 publications

References 18 publications

Residents of Industrial Regions: Long Term Dynamics of Spontaneous Mutagenesis

Residents of Industrial Regions: Long Term Dynamics of Spontaneous Mutagenesis

Cytogenetic analysis of coke oven workers in Eastern Slovakia

Materials Selection for Production of Microspheres Protecting Lactoferrin Under Acid Conditions

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