Chromosome changes in a patient achieving complete remission in the acute phase of chronic myelogenous leukemia

Stern, Ronald; Sorenson, Julie; Wurster‐Hill, Doris H.; Cornwell, Gibbons G.; McIntyre, O. Ross

doi:10.1002/ajh.2830060208

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…After the first course of combined chemotherapy, normal hematopoiesis without the Ph chromosome appeared. Although the Ph chromosome has been reported to have disappeared in a few cases of blastic crisis of CML [9], the appearance of normal hematopoiesis strongly suggested de novo Phpositive acute leukemia in the present case.…”

Section: Discussionmentioning

confidence: 46%

A de novo Philadelphia chromosome-positive acute mixed-lineage leukemia with both major and minorBCR/ABL mRNA transcripts

et al. 2000

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A patient with a Philadelphia chromosome (Ph)-positive acute mixed-lineage leukemia (AMLL) expressing both major and minor BCR/ABL mRNA transcripts is described. Phenotypic analysis of the leukemic blasts revealed positivity for both myeloid and B-cell lineages. Southern blot analysis showed a rearrangement of the immunoglobulin heavy chain (IgH) gene. Reverse transcriptase polymerase chain reaction (RT-PCR) analysis showed the expression of both major and minor BCR/ABL mRNA transcripts. To our knowledge, this is the first report of AMLL expressing both major and minor BCR/ABL mRNA transcripts and rearrangement of the IgH gene.

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Section: Discussionmentioning

confidence: 46%

A de novo Philadelphia chromosome-positive acute mixed-lineage leukemia with both major and minorBCR/ABL mRNA transcripts

et al. 2000

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Chromosomal characteristics of chronic and blastic phases of Ph-positive chronic myeloid leukemia

Sadamori

Matsunaga

Yao

et al. 1985

Cancer Genetics and Cytogenetics

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Dual Rearrangement of Immunoglobulin and T-cell Receptor Genes in a Case of Philadelphia Chromosome-positive Acute Leukemia

Wakimoto

Mukai

Kuwada

et al. 1998

Japanese Journal of Clinical Oncology

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A 48-year-old patient was admitted to our hospital for leukocytosis. The blastcells were positive for peroxidase and he was tentatively diagnosed as acute myeloid leukemia according to the French-American-British criteria. By flow cytometry, the bone marrow cells were positive for CD10, CD13, CD33 and HLA-DR, but two-color analysis revealed that most of the CD13-and CD33-positive cells did not express CD1 O. The marrow cells had Philadelphia chromosome with no additional abnormalities. Major bcr-abl fusion gene was observed by the reverse transcriptase-polymerase chain reaction method. Southern blot analysis disclosed rearrangement of both immunoglobulin heavy chain and T-cell receptor beta chain genes. He received combined chemotherapy for myeloid lineage and lymphoid lineage, but the response was quite poor. Hedied64 daysafteradmission due to pulmonary bleeding. Although the association of Ph 1 with multilineage differentiation is unclear, our case has significant implication for further investigation of the relationship between Ph1-positive cells and lineage selection.

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Chromosome changes in a patient achieving complete remission in the acute phase of chronic myelogenous leukemia

Cited by 4 publications

References 16 publications

A de novo Philadelphia chromosome-positive acute mixed-lineage leukemia with both major and minorBCR/ABL mRNA transcripts

A de novo Philadelphia chromosome-positive acute mixed-lineage leukemia with both major and minorBCR/ABL mRNA transcripts

Chromosomal characteristics of chronic and blastic phases of Ph-positive chronic myeloid leukemia

Dual Rearrangement of Immunoglobulin and T-cell Receptor Genes in a Case of Philadelphia Chromosome-positive Acute Leukemia

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