Chromosome Number and Morphology of Benign Ovarian Cystic Teratomas

Corfman, Philip A.; Richart, Ralph M.

doi:10.1056/nejm196412102712405

Cited by 38 publications

(7 citation statements)

References 16 publications

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“…The karyotypes of all benign ovarian teratomas are 46XXX. 4,9,12,20…”

Section: Embryologymentioning

confidence: 99%

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An Evaluation of the Incidence of Right-Sided Ovarian Cystic Teratoma Visualized on Sonograms

Ismail¹

2005

Journal of Diagnostic Medical Sonography

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This study set out to determine the incidence of right-sided ovarian cystic teratoma. The author examined 270 cases of ovarian cystic teratoma. In this series, ovarian dermoids were more frequently found on the right ovary than the left ovary. The primary data were obtained over two decades and include both retrospective and prospective review. The data included the clinical history of each patient, pelvic sonography examination, and microscopic and/or surgical findings reports. Data used were limited to proven cases of ovarian cystic teratoma shown by sonography and confirmed by histology. Results demonstrate that 195 dermoids (72.22%) were located on the right ovary, 47 dermoids were found on the left side (17.41%), and 28 dermoids were found bilaterally (10.37%). The results indicate that the incidence of unilateral dermoids occurs more often on the right side.

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“…The karyotypes of all benign ovarian teratomas are 46XXX. 4,9,12,20…”

Section: Embryologymentioning

confidence: 99%

“…19 The anatomical distribution of tumors along the line of migration of the primordial germ cells from the yolk sac to the primitive gonad supports this theory. 16,20 The theory of design is controversial. A study was undertaken to determine the laterality of cystic ovarian teratomas.…”

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confidence: 99%

An Evaluation of the Incidence of Right-Sided Ovarian Cystic Teratoma Visualized on Sonograms

Ismail¹

2005

Journal of Diagnostic Medical Sonography

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“…Thus, apart from the mentioned germ cell origin, arising in a number of different ways, somatic cell origin or an origin from a blastomere that was an identical twin of the patient has also been. Although most teratomas have a typical 46,XX karyotype (10), mosaicism has been also found in some (11). Chromosomally abnormal teratomas have been revealed, including trisomy, double trisomy and tetrasomy (12).…”

Section: Introductionmentioning

confidence: 99%

Retrospective evaluation of pathological results among women with ovarian endometriomas versus teratomas

et al. 2019

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The coexistence of endometrioma with dermoid cyst of the ovaries is an unusual entity, although they are both common and benign gynecological tumors. The present study aimed to investigate the association between ovarian dermoid cyst (teratoma) and endometrioma. We retrospectively, included 315 women with endometrioma and 172 with ovarian teratoma. Data were collected from medical and pathological reports from two different areas between 1995 and 2018. The mean age of cases with endometrioma was similar (35.8±7.2 years) to patients with ovarian teratoma (34.2±6.8 years). Considering the types of dermoid cysts, the observed proportion of mature type was 168/172 (98%), the immature type was 4/172 (2%) and struma ovarii was14/172 (8.1%) respectively. Endometrioma was significantly more frequent in the left ovary [174/266 (65.4%)] than in the right ovary [92/266 (34.6%)], P<0.001. By contrast, ovarian teratoma were predominant in the right ovary, 98/172 (60.6%), compared to the left side, 56/172 (32.5%), P<0.001. Regarding the size of the masses, we detected an inverse distribution between the two groups. Thirteen women were detected with ovarian teratoma and endometriosis, with 6 cases being in the same ovary. Our results indicate a left lateral predispostion of endometrioma and a right of ovarian teratoma and suggest that the pathogenesis between these conditions is different. The coexistence of endometriosis with dermoid cyst of the ovary, presents a challenge to the physicians and the investigators. Further research is required to establish the relationship between endometriosis and ovarian teratoma.

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“…' The different theories of their origin have arisen from studies of their location, of the degree and kind of organization of the tissue types within them,' and of their possible relationship with other gonadal tumors.2 3 They have a normal diploid karyotype. 4 This study was undertaken in an attempt to test the theory that dermoid cysts in human females arise from a germ cell after, or at the time of, meiotic division. Mammalian eggs begin meiosis in utero, and by the time of birth they are at diplotene.5 A tumor formed after meiotic division is completed should be missing half the chromosomes of the individual.…”

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confidence: 99%

Gene Loss in Human Teratomas

Linder

1969

Proc. Natl. Acad. Sci. U.S.A.

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Abstract.-If benign cystic teratomas (dermoid cysts) of the ovary arise from a germ cell that has undergone meiosis, they should be missing genes which are present in the person. Three independently segregating allelic isozymes in 11 benign cystic teratomas of the human female ovary were compared with normal tissue of the same case. Dermoid cysts from persons heterozygous for these isozymes are frequently homozygous for that particular gene product. One of two dermoid cysts is homozygous for glucose-6-phosphate dehydrogenase, two of four tumors are homozygous for phosphoglucomutase at the PGM, locus, and two (or more) of eight tumors are homozygous for phosphoglucomutase at the PGM3 locus in women heterozygous for these allelic isozymes. These findings are consistent with the hypothesis that these tumors arise from a germ cell which has undergone meiosis with varying degrees of crossing-over.Introduction.-Benign cystic teratomas (dermoid cysts) are found relatively frequently in human females. Most of them arise in the gonads; less frequent sites are the mediastinum, the retroperitoneum, and the presacral and coccygeal regions.' The different theories of their origin have arisen from studies of their location, of the degree and kind of organization of the tissue types within them,' and of their possible relationship with other gonadal tumors.2 3 They have a normal diploid karyotype.4This study was undertaken in an attempt to test the theory that dermoid cysts in human females arise from a germ cell after, or at the time of, meiotic division. Mammalian eggs begin meiosis in utero, and by the time of birth they are at diplotene.5 A tumor formed after meiotic division is completed should be missing half the chromosomes of the individual. One would then expect that some genes which are heterozygous in the patient would be homozygous in the tumor. This study uses two common electrophoretic variants (allelic isozymes) of two autosomal, independently segregating genes for phosphoglucomutase (PGM)6' 7 and the X-linked gene, glucose-6-phosphate dehydrogenase (G6PD)8 as genetic markers to compare the phenotype of the host with that of the tumor.

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Chromosome Number and Morphology of Benign Ovarian Cystic Teratomas

Cited by 38 publications

References 16 publications

An Evaluation of the Incidence of Right-Sided Ovarian Cystic Teratoma Visualized on Sonograms

An Evaluation of the Incidence of Right-Sided Ovarian Cystic Teratoma Visualized on Sonograms

Retrospective evaluation of pathological results among women with ovarian endometriomas versus teratomas

Gene Loss in Human Teratomas

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