Chronic administration of growth hormone-releasing factor increases wound strength and collagen maturation in granulation tissue

Garrel, Dominique R.; Gaudreau, Pierrette; Zhang, Limin; Reeves, Isabelle; Brazeau, Paul

doi:10.1016/0022-4804(91)90111-x

Cited by 35 publications

(21 citation statements)

References 21 publications

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“…Higher doses of GH have been used successfully to promote healing at skin‐graft sites in burn victims 8 . Mixed results have been obtained for the use of GH in healing other types of wounds 9–11 . GH has also been suggested as a metabolic treatment for Alzheimer's disease 12 …”

Section: Human Studies On the Effect Of Exercise On Growth Hormone mentioning

confidence: 99%

Growth Hormone, Exercise, and Aging: The Future of Therapy for the Frail Elderly

Borst

Millard

Löwenthal

1994

J American Geriatrics Society

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Section: Human Studies On the Effect Of Exercise On Growth Hormone mentioning

confidence: 99%

Growth Hormone, Exercise, and Aging: The Future of Therapy for the Frail Elderly

Borst

Millard

Löwenthal

1994

J American Geriatrics Society

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“…It has been previously shown that rhGH directly stimulates collagen synthesis in the wound and increases tensile strength. 35–37 However, if growth hormone improves wound healing by collagen synthesis in the wound, one might also expect it to contribute to the formation of hypertrophic scars. In previous studies, we showed that administration of rhGH during the acute hospitalization showed no adverse clinical effects at 2 years postburn.…”

Section: Discussionmentioning

confidence: 99%

Randomized Controlled Trial to Determine the Efficacy of Long-Term Growth Hormone Treatment in Severely Burned Children

et al. 2009

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Background Recovery from a massive burn is characterized by catabolic and hypermetabolic responses that persist up to 2 years and impair rehabilitation and reintegration. The objective of this study was to determine the effects of long-term treatment with recombinant human growth hormone (rhGH) on growth, hypermetabolism, body composition, bone metabolism, cardiac work, and scarring in a large prospective randomized single-center controlled clinical trial in pediatric patients with massive burns. Patients and Methods A total of 205 pediatric patients with massive burns over 40% total body surface area were prospectively enrolled between 1998 and 2007 (clinicaltrials.gov ID NCT00675714). Patients were randomized to receive either placebo (n = 94) or long-term rhGH at 0.05, 0.1, or 0.2 mg/kg/d (n = 101). Changes in weight, body composition, bone metabolism, cardiac output, resting energy expenditure, hormones, and scar development were measured at patient discharge and at 6, 9, 12, 18, and 24 months postburn. Statistical analysis used Tukey t test or ANOVA followed by Bonferroni correction. Significance was accepted at P < 0.05. Results RhGH administration markedly improved growth and lean body mass, whereas hypermetabolism was significantly attenuated. Serum growth hormone, insulin-like growth factor-I, and IGFBP-3 was significantly increased, whereas percent body fat content significantly decreased when compared with placebo, P < 0.05. A subset analysis revealed most lean body mass gain in the 0.2 mg/kg group, P < 0.05. Bone mineral content showed an unexpected decrease in the 0.2 mg/kg group, along with a decrease in PTH and increase in osteocalcin levels, P < 0.05. Resting energy expenditure improved with rhGH administration, most markedly in the 0.1 mg/kg/d rhGH group, P < 0.05. Cardiac output was decreased at 12 and 18 months postburn in the rhGH group. Long-term administration of 0.1 and 0.2 mg/kg/d rhGH significantly improved scarring at 12 months postburn, P < 0.05. Conclusion This large prospective clinical trial showed that long-term treatment with rhGH effectively enhances recovery of severely burned pediatric patients.

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“…The effects of GH on wound healing are not well understood. 14 In some species, GH is suggested to stimulate collagen synthesis by fibroblasts and accelerate collagen maturation in a dose-dependent manner resulting in enhanced wound strength. 13,14,[22][23][24] These effects are believed to be mediated directly through receptors on target cells and through various growth factors.…”

Section: Discussionmentioning

confidence: 99%

“…14 In some species, GH is suggested to stimulate collagen synthesis by fibroblasts and accelerate collagen maturation in a dose-dependent manner resulting in enhanced wound strength. 13,14,[22][23][24] These effects are believed to be mediated directly through receptors on target cells and through various growth factors. 1,14,24 Growth factors may play a significant role in cell migration and activity during the entire healing process and have successfully been used to increase cutaneous wound strength.…”

Section: Discussionmentioning

confidence: 99%

“…8 The role of GH in human growth and development is well established. [9][10][11][12][13][14][15][16][17][18][19] In laboratory animal models, GH has a beneficial effect on healing of skin wounds and colonic anastomoses [9][10][11][12][13][14][15][16][17][18][19] ; however, the effect of GH on wound healing in horses has not been studied. [16][17][18][19] Equine recombinant growth hormone (rEGH; equine growth hormone; Bresagen, Adelaide, Australia) reportedly causes a dose-dependent increase in muscle definition in aged mares 16 ; however, evidence of a direct anabolic effect remains to be established.…”

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confidence: 99%

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The Effect of Equine Recombinant Growth Hormone on Second Intention Wound Healing in Horses

et al. 2002

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Chronic administration of growth hormone-releasing factor increases wound strength and collagen maturation in granulation tissue

Cited by 35 publications

References 21 publications

Growth Hormone, Exercise, and Aging: The Future of Therapy for the Frail Elderly

Growth Hormone, Exercise, and Aging: The Future of Therapy for the Frail Elderly

Randomized Controlled Trial to Determine the Efficacy of Long-Term Growth Hormone Treatment in Severely Burned Children

The Effect of Equine Recombinant Growth Hormone on Second Intention Wound Healing in Horses

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