Chronic and acute stress monitoring by electrophysiological signals from adrenal gland

Sunwoo, Sung; Lee, Ju Seung; Bae, Sungjun; Shin, Yiel Jae; Kim, Chang Seong; Joo, Soo Yeon; Choi, Hong Sang; Suh, Minah; Kim, Soo Wan; Choi, Young Jin; Kim, Tae Il

doi:10.1073/pnas.1806392115

Cited by 54 publications

(35 citation statements)

References 57 publications

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“…Glucocorticoids and HPA axis involvement have been extensively described under acute stress, but their functioning throughout chronic stress and particularly in the workplace still requires clarification (Elbau et al, 2018;Rohleder, 2018;Sunwoo et al, 2019).…”

Section: Burnout and Cortisolmentioning

confidence: 99%

From Work Well-Being to Burnout: A Hypothetical Phase Model

et al. 2020

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Upon exposure to chronic stressors, how do individuals move from being in a healthy state to a burnout? Strikingly in literature, this has prevailed a categorical view rather than a dimensional one, thus the underlying process that explains the transition from one state to another remains unclear. The aims of the present study are (a) to examine intermediate states between work engagement and burnout using cluster analysis and (b) to examine cortisol differences across these states. Two-hundred and eighty-one Argentine workers completed self-report measures of work engagement and burnout. Salivary cortisol was measured at three time-points: immediately after awakening and 30 and 40min thereafter. Results showed four different states based on the scores in cynicism, exhaustion, vigor, and dedication: engaged, strained, cynical, and burned-out. Cortisol levels were found to be moderate in the engaged state, increased in the strained and cynical states, and decreased in the burned-out state. The increase/decrease in cortisol across the four stages reconciles apparent contradictory findings regarding hypercortisolism and hypocortisolism, and suggests that they may represent different phases in the transition from engagement to burnout. A phase model from engagement to burnout is proposed and future research aimed at evaluating this model is suggested.

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Section: Burnout and Cortisolmentioning

confidence: 99%

From Work Well-Being to Burnout: A Hypothetical Phase Model

et al. 2020

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“…The stress response is a collective term that includes neural, endocrine, and other physiological responses to environmental, psychological, and/or homeostatic stressors. 1,2) When stimulated by stressors such as hunger, disease, and fear, multiple coordinated systems are activated-such as the hypothalamic pituitary adrenal (HPA) axis 3) and the sympathetic nervous system (SNS) 4) -which can promote cognition, immune function, metabolism, and homeostasis of the internal environment. However, long-term stress can reverse the beneficial and protective effects of acute stress, leading to serious diseases.…”

Section: Introductionmentioning

confidence: 99%

The Role of Potassium Channels in Chronic Stress-Induced Brain Injury

Ren

Guo

Zhu

et al. 2021

Biological & Pharmaceutical Bulletin

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Chronic stress-induced brain injury (CSBI) is the organic damage of brain tissue caused by long-term psychological and environmental stress. However, there is no effective drug for the treatment of CSBI. The present study aimed to investigate possible mechanisms of CSBI and to explore related therapeutic targets. A rat model of CSBI was established by combining chronic restraint and cold water immersion. Our CSBI model was validated via Nissl staining, Western blotting, and behavioral tests. RNA sequencing (RNA-seq) was used to identify differentially expressed genes (DEGs) within brain tissue during CSBI. Both Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses were performed to determine signaling pathways associated with CSBI-induced DEGs. Agonists/antagonists were used to validate the pharmacodynamics of potential therapeutic targets. A combination of chronic restraint and cold water immersion successfully induced a rat model of CSBI, as indicated by various markers of brain injury and cell apoptosis that were verified via Nissl staining, Western blotting, and behavioral tests. RNA-seq analysis identified 1,131 DEGs in CSBI rats. Of these DEGs, 553 genes were up-regulated and 778 genes were down-regulated. GO and KEGG pathway analyses revealed that significant DEGs were predominantly related to membrane-bound ion channels, among which the potassium channel function was found to be significantly affected. Pharmacological experiments revealed that retigabine, a voltage-gated potassium Biological and Pharmaceutical Bulletin Advance Publication channel opener, demonstrated a protective effect in CSBI rats. Taken together, our findings suggest that potassium channel function is disrupted in CSBI, and that potassium channel regulators may function as anti-CSBI drugs.

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“…Various electrophysiological signals, such as electrocardiography, [ 162 ] electromyography, [ 163 ] etc., are effective indicators for evaluating human health. [ 164–166 ] In general, a electrophysiological sensor consists of three kinds of electrodes (i.e., recording, reference, and ground electrode) conformally attaching to the human skin ( Figure a). [ 167 ] Consider that the biopotentials generated by organ, tissue, and neuronal activities possibly show a frequency down to 1 Hz and voltage as low as 1 µV.…”

Section: Applications Of Pda Flexible Bioelectronicsmentioning

confidence: 99%

Flexible Polydopamine Bioelectronics

Jin

Yang

Shi

et al. 2021

Adv Funct Materials

131

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Flexible bioelectronics have attracted increasing research interests due to their wide range of potential applications in human motion detection, personal healthcare monitoring, and medical diagnosis. Recently, design and fabrication strategies integrated with mussel-inspired polydopamine (PDA) have demonstrated many appealing properties, which meet the structural and functional requirements of high-performance flexible bioelectronics. The inherent multiple reactive sites and hierarchical interactions within PDA can promote the total electrochemical activities, self-healing, surface activation, and biocompatibility of the composite system. This review paper strives to provide a comprehensive overview on this emerging area, including the fabrication methodology, the structural and functional contributions of PDA on the whole composites, and various applications of PDA-based flexible bioelectronics. The current challenges and future outlook in this field are also extensively discussed at the end. This paper aims to serve as a guideline in this emerging area and provide new inspirations toward next-generation integrated multifunctional flexible PDA bioelectronics with a broad range of healthcare applications.

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Chronic and acute stress monitoring by electrophysiological signals from adrenal gland

Cited by 54 publications

References 57 publications

From Work Well-Being to Burnout: A Hypothetical Phase Model

From Work Well-Being to Burnout: A Hypothetical Phase Model

The Role of Potassium Channels in Chronic Stress-Induced Brain Injury

Flexible Polydopamine Bioelectronics

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