Chronic
            <b>Chlamydia pneumoniae</b>
            Infection and Stroke in Cameroon

Njamnshi, Alfred K.; Blackett, Kathleen Ngu; Mbuagbaw, J.N.; Gumedze, Freedom; Gupta, Sandeep; Wiysonge, Charles Shey

doi:10.1161/01.str.0000204223.04182.4a

Cited by 24 publications

(17 citation statements)

References 46 publications

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“…They found that positive serum IgG and IgA antibody titer by microimmunofluorescence (MIF) test, against C. pneumoniae was significantly more in ischemic stroke patients compared to age and sex matched control subjects [8,9]. This is in agreement with previous studies where C. pneumoniae antibody positivity has been noted in young stroke patients [3,47].…”

Section: Stroke An Immunopathogenic Complication Of Persistent C Pnsupporting

confidence: 86%

“…In Cameroon, Njamnshi AK et al demonstrated that C. pneumoniae infection is significantly associated with ischemic stroke in patients in the < 50 years age group compared to matched www.intechopen.com controls [47]. Another study also demonstrated that C. pneumoniae seropositivity can increase the risk of stroke in young patients aged below 55 years in which, C. pneumoniae seropositivity in all ischemic stroke subgroups except stroke of indeterminate etiology is found [8].…”

Section: Stroke An Immunopathogenic Complication Of Persistent C Pnmentioning

confidence: 98%

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Pathogenesis of Chlamydia pneumonia Persistent Illnesses in Autoimmune Diseases

Honarmand¹

2012

Chlamydia

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Section: Stroke An Immunopathogenic Complication Of Persistent C Pnsupporting

confidence: 86%

Section: Stroke An Immunopathogenic Complication Of Persistent C Pnmentioning

confidence: 98%

Pathogenesis of Chlamydia pneumonia Persistent Illnesses in Autoimmune Diseases

Honarmand¹

2012

Chlamydia

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“…In Cameroon, some studies have been carried on patients in the intensive care units [7] [8], sickle cell children [4] [6] and on risk factors of stroke [5] [10]. The only study that employed modern imaging technique (CT or MRI) is that of Chiasseu and Mbahe [9] although it looked mainly at less severe stroke in a small sample and very little information was reported on stroke subtypes.…”

Section: Discussionmentioning

confidence: 99%

Stroke Epidemiology in Douala: Three Years Prospective Study in a Teaching Hospital in Cameroon

Mapoure¹,

Kuate²,

Tchaleu³

et al. 2014

WJNS

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Background and Objectives: Cerebro-vascular accident or stroke constitutes a major challenge in sub-Saharan Africa. In Cameroon, basic epidemiologic data are not routinely available. Aims: The aim of this study was to determine the type, the associated risk factors, time to admission, the clinical presentation and the case fatality of stroke at the Douala General Hospital (DGH) in Cameroon. Methods: A cross-sectional study was performed from January 1, 2010 to December 31, 2012 at the neurology and intensive care units of the DGH. All patients above 15 years of age with a diagnosis of established stroke were enrolled. For each patient, socio-demographic, clinical and paraclinical data were recorded as well as the duration of hospitalization and the case fatality. Results: In all, 325 patients were enrolled with males constituting 68.1% and general mean age of 58.66 ± 13.6 years. The mean initial consultation delay was 47.36 ± 18.48 hours. The majors cerebro-vascular risk factors were hypertension (81.15%), chronic alcohol consumption (28.3%), diabetes mellitus (20.61%), obesity (18.15%), cigarette smoking (16%), dyslipidemia (8.9%) and atrial fibrillation (3.07%). Ischemic stroke accounted for 52% of cases while 48% were hemorrhagic. The mean duration of hospitalization was 8.58 ± 6.35 days with a case fatality rate of 26.8%. Septic conditions appeared to be the leading cause of death accounting for 35.6% of cases. Y. N. Mapoure et al. 407Conclusion: Stroke in the DGH is associated with a high case fatality rate and hypertension remains the number one risk factor. There is a clear and urgent need for public health authorities to reinforce measures for the control of modifiable stroke risk factors.

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“…In Medrano's study, there was no relationship between IgG antibodies against C. pneumoniae and cerebrovascular accidents (18). In another study in Cameroon, 64% of the patients with ischemic stroke had IgG against C. pneumoniae, compared to 55% positivity in the control group, the difference of which was not statistically significant (7).…”

Section: Discussionmentioning

confidence: 86%

“…In addition, inflammation has been postulated to play an important role in initiation and development of atherosclerosis. Retrospective and cross-sectional studies have suggested that both bacterial and viral infections may be risk factors for atherosclerosis, ischemic stroke and acute coronary events (7)(8)(9)(10)(11). Some studies do not confirm the association between seropositivity to C. pneumoniae and increased risk of cardiovascular diseases in populations with stroke (12).…”

Section: Introductionmentioning

confidence: 99%

The Association Between Chlamydia pneumoniae Infection and Ischemic Stroke

Eini¹,

Keramat²,

Farajpoor³

2014

Avicenna J Clin Microbiol Infect

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Background: Chlamydia pneumoniae has been linked with increased risk of cardiovascular diseases; however, data on stroke and cerebrovascular accidents are sparse. Objectives: The aim of this study was to determine the association between C. pneumoniae infection and ischemic stroke. Patients and Methods:In a case-control study, 141 patients, admitted with ischemic stroke, were compared with gender and age-matched control subjects (n = 141). Using an enzyme-linked immunosorbent assay kit, the presence of C. pneumoniae IgG and IgA in the patients' sera was determined. The data were analyzed by SPSS software (version 15) and were compared between the two groups using T-test and chi square test. Results: The mean ages of the case and control groups were 68.97 ± 12.29 and 66.95 ± 6.68 years old, respectively. The difference between these two groups was not statistically significant (P = 0.102). The seroprevalence of C. pneumoniae-specific IgG were 78.7% in the patients with stroke and 52.5% in the control group. The difference between the two groups was statistically significant (P = 0.0001). The seroprevalence of C. pneumoniae-specific IgA were 41.1% in the stroke and 15.6% in the control group. The difference between the two groups was statistically significant (P = 0.0001). Conclusions:The results supported the hypothesis that serological evidence of C. pneumoniae infection may be associated with an increased risk of ischemic stroke and cerebrovascular accident.

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Chronic Chlamydia pneumoniae Infection and Stroke in Cameroon

Abstract: Background and Purpose-To determine the relationship between chronic Chlamydia pneumoniae infection and stroke in Cameroon. Methods

Cited by 24 publications

References 46 publications

Pathogenesis of Chlamydia pneumonia Persistent Illnesses in Autoimmune Diseases

Pathogenesis of Chlamydia pneumonia Persistent Illnesses in Autoimmune Diseases

Stroke Epidemiology in Douala: Three Years Prospective Study in a Teaching Hospital in Cameroon

The Association Between Chlamydia pneumoniae Infection and Ischemic Stroke

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