Chronic Cadmium Exposure-Induced Renal Anemia in Ovariectomized Rats

Hiratsuka, Hideaki; Katsuta, Osamu; Toyota, Naoto; Tsuchitani, Minoru; Umemura, Takashi; Marumo, Fumiaki

doi:10.1006/taap.1996.0076

Cited by 45 publications

(33 citation statements)

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“…injection of Cd to OX female rats over fifty weeks, osteoporosis with osteomalacia, renal tubular nephropathy, and renal anemia, which were the main pathological changes of IID, could be reproduced in the present study. These results confirm our previous reports in which the characteristic pathologies of human IID were reproduced by Cd treatment for thirteen weeks (Katsuta et al 1994) and fifty to seventy weeks (Hiratsuka et al 1996) in OX rats. In the present study, fibrous oteodystrophy was also observed in the Cd-treated rats.…”

Section: Discussionsupporting

confidence: 93%

The Effects of a Vitamin D–deficient Diet on Chronic Cadmium Exposure in Rats

et al. 2010

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Itai-itai disease (IID) of humans is one of the most severe forms of chronic cadmium (Cd) intoxication. Itai-itai disease occurs mainly in postmenopausal women and is characterized by osteoporosis with osteomalacia, renal tubular disorder, and renal anemia. Some researchers insist the major cause of IID is not Cd, but rather malnutrition, especially hypovitaminosis D. We administrated a low concentration of Cd chloride intravenously to ovariectomized female rats that were fed a vitamin D-deficient diet or a normal diet for fifty weeks. The vitamin D-deficient diet decreased serum concentration of vitamin D, but it did not affect the metabolism of the kidney or bone. Cadmium treatment alone induced a decrease in serum concentration of vitamin D, as well as renal dysfunction, renal anemia, and abnormal bone metabolism. Osteoporosis with osteomalacia, tubular nephropathy, fibrous osteodystrophy, and bone marrow hyperplasia occurred following Cd treatment. In rats treated with Cd and administered a vitamin D-deficient diet, the toxic effects of Cd on kidney, bone, and hematopoiesis were enhanced in comparison to rats treated with Cd and a normal diet. The present experiment demonstrated that hypovitaminosis D did not evoke morphologic features of IID in humans but did enhance Cd-induced toxicity in the rat model of this disease.

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Section: Discussionsupporting

confidence: 93%

The Effects of a Vitamin D–deficient Diet on Chronic Cadmium Exposure in Rats

et al. 2010

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“…However, lower levels of iron in the exposed rat organisms were reported in this case. Similar effect was observed by Hiratsuka et al (1996) in rats intravenously exposed to Cd. Also Turgut et al (2007) described that high cadmium and lead decreased iron absorption and negatively affected hematological parameters.…”

Section: Discussionsupporting

confidence: 82%

Effect of the diet amended with risk elements contaminated soil on risk elements content in tissues and hematological parameters of rats

Száková¹,

Novosadová²,

Zidek³

et al. 2012

CZECH J ANIM SCI

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Penetration of rat organisms by risk elements (As, Cd, Pb) originated from differently contaminated soils as well as interactions between the risk elements and selected essential macro-and microelements were investigated. Rat diet contained 10% of individual soils (based on dry weight) which were: (i) Fluvisol heavily polluted by As, Cd, Zn, and Pb, (ii) Luvisol contaminated by As, Cd, and Zn, and (iii) uncontaminated Chernozem. Male Wistar rats used for the experiment were housed in cages in a room with controlled temperature for 60 days and fed ad libitum on the mentioned diet. The levels of both risk and essential elements were measured in liver, kidney, and bones of the animals and main biochemical parameters were determined to assess potential toxic effect of the soil-derived risk elements. Alternatively, in vitro Physiologically Based Bioavailability Test (PBET) was used for evaluation of the bioaccessible pool of elements in the soil-amended diets. The element contents in the rat tissues reflected the risk element contents in the contaminated soils. Bioaccessibility and bioavailability of the risk elements decreased in the order Cd > As > Pb and were influenced by the soil physicochemical parameters. Significant changes in essential elements (Cu, Fe, Mg, P) deposition in rat tissues attended the high levels of the risk elements. Total leukocyte count in the blood of the rats fed the heavy polluted soil indicated adverse effect of soil-derived risk elements on biochemical parameters of the animals.

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“…The renal injury as a result of long-term cadmium exposure was frequently reported (Hiratsuka et al 1996;El-Demerdash et al 2004;Borgese et al 2008). Hypoglykaemia resulting from the singledose cadmium application was reported due to disability of gluconeogenesis caused by the liver injury by Adachi et al (2007).…”

Section: Discussionmentioning

confidence: 99%

Long-term effect of diet amended by risk elements contaminated soils on risk element penetration and physiological parameters of rats

Vlčková¹,

Malinová²,

Koubková³

et al. 2014

CZECH J ANIM SCI

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ABSTRACT:The long-term accumulation of risk elements (As, Cd, Pb) originated from differently contaminated soils in rat organism was investigated during a model two-generation experiment. The effect of soil contamination level, gender, and length of exposure as well as the interactions between risk elements and selected essential macro-and microelements were studied. Rat diet contained 10% of individual soils (based on dry weight): (i) Fluvisol heavily polluted by As, Cd, Zn, and Pb, (ii) Luvisol contaminated by As, Cd, and Zn, and (iii) uncontaminated Chernozem. Male and female Wistar rats used for the experiment were housed in cages in a room with controlled temperature for 60 days and were fed ad libitum the mentioned diets. Subsequently, the pregnant females were continuously fed the experimental diet until weaning when the young animals were separated to male and female and fed the experimental diet till day 110 of age. The element contents in rat tissues reflected the risk element contents in contaminated soils. The bioaccessibility and bioavailability of the risk elements decreased in the order Cd>As>Pb and was affected by the soil physicochemical parameters. No significant differences were observed between male and female rats as well as between the first and the second generation. However, interactions were reported among the risk elements where the high cadmium content in Fluvisol resulted in increasing arsenic accumulation in the rat liver. Moreover, arsenic-copper interactions were observed where significant increase of the copper level was determined in kidney of the animals fed Luvisol exceeding 50-fold the maximum permissible limits for As content in agricultural soils. Among the hematological and biochemical characteristics of rats, total erythrocyte count (Er), hematocrit (Hct) increased confirming adverse effect of soil-derived risk elements especially in male rats.

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Chronic Cadmium Exposure-Induced Renal Anemia in Ovariectomized Rats

Cited by 45 publications

References 0 publications

The Effects of a Vitamin D–deficient Diet on Chronic Cadmium Exposure in Rats

The Effects of a Vitamin D–deficient Diet on Chronic Cadmium Exposure in Rats

Effect of the diet amended with risk elements contaminated soil on risk elements content in tissues and hematological parameters of rats

Long-term effect of diet amended by risk elements contaminated soils on risk element penetration and physiological parameters of rats

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