Chronic comorbidities in children with type 1 diabetes: a population-based cohort study

Farsani, Soulmaz Fazeli; Souverein, Patrick C.; Vorst, Marja M J van der; Knibbe, Catherijne A. J.; Boer, Anthonius de; Mantel‐Teeuwisse, Aukje K.

doi:10.1136/archdischild-2014-307654

Cited by 29 publications

(28 citation statements)

References 39 publications

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“…Although studies involving multimorbidity have been predominantly conducted in adults and older adults with chronic diseases , our findings are in agreement with recent research involving other age groups, which has shown that multiple chronic conditions and psychiatric disorders are prevalent in children. According to our findings, two or more oral clinical conditions were found in 26.9% of children, suggesting that multimorbidity is a phenomenon related to the distribution of different health conditions, including oral diseases.…”

Section: Discussionsupporting

confidence: 90%

Multimorbidity patterns of oral clinical conditions, social position, and oral health-related quality of life in a population-based survey of 12-yr-old children

et al. 2016

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The aim of this study was to describe the patterns of multimorbidities of oral clinical conditions in children. The association between social position and number of oral clinical conditions, and the relationship of social position and number of oral clinical conditions with oral health‐related quality of life [OHRQoL, measured using the Brazilian Child‐Oral Impacts on Daily Performance (Child‐OIDP)] were also investigated. The study analysed data on 7,208 children, 12 yr of age, from the Brazilian Oral Health Survey (SBBrasil Project). Cluster analysis based on the observed/expected (O/E) ratios identified six significant clusters of oral clinical conditions: (i) dental caries and missing teeth; (ii) dental caries and dental trauma; (iii) dental trauma and gingivitis; (iv) dental caries, missing teeth, and dental trauma; (v) dental caries, dental trauma, and gingivitis; and (vi) all oral clinical conditions. Ordinal regression showed that poor social position was associated with a large number of oral clinical conditions. Poisson regression demonstrated that low social position and greater number of oral clinical conditions increased the likelihood of poor OHRQoL (Child‐OIDP extent). The four oral clinical conditions clustered into six distinct clusters among Brazilian children. Multimorbidity of oral clinical conditions predicted poor OHRQoL. Social position was of high relevance to multimorbidity of oral clinical conditions and children′s OHRQoL.

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Section: Discussionsupporting

confidence: 90%

Multimorbidity patterns of oral clinical conditions, social position, and oral health-related quality of life in a population-based survey of 12-yr-old children

et al. 2016

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“…While we were able to estimate T2DM-related morbidity and mortality in the present study, it is important to interpret the results with caution, as individuals suffering from DM often have comorbidities related to mental health, gastrointestinal, and musculoskeletal health [ 32 , 33 ]. It is possible that the data on underlying causes of death may have been limited in many countries, resulting in an underestimation of T2DM-related mortality [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Sex differences and risk factors for diabetes mellitus - an international study from 193 countries

et al. 2018

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BackgroundIncreases in overweight and obesity among youths have resulted in the diagnosis of Type 2 diabetes mellitus (T2DM) at earlier ages. The impact of lifestyle-related factors has been implicated; however, its relation to morbidity and mortality and sex differences remain unclear. We aimed to document the changes in risk factors and sex differences associated with T2DM-related morbidity and mortality during 1995–2015.MethodWe used mortality rates and morbidity estimates from the Global Burden of Diseases Study 2016 using Disability-Adjusted Life Years (DALY). Multiple linear regression analyses were used to determine associations between T2DM-related mortality and related risk factors. DALYs were grouped by country income level, and were stratified by sex.ResultsIncreases in mortality were observed for both sexes, and females tended to have higher mortality rates per 100,000 persons. Body mass index (BMI) continued to be the leading risk factor for T2DM-related mortality, and increases in BMI were more common in low- and middle-income countries (LIC and MIC). Low physical activity was strongly associated with mortality rates, followed by dietary risks and smoking (2.4; 1.4; 0.8 per 100,000 persons, respectively). Similar patterns were observed after adjustments for income level, sex, and age. DALYs continued to show increasing trends across all income levels during 1995–2015 (high-income (HIC):16%; MIC: 36%; LIC: 12%). Stratification by sex showed similar results; males had fewer T2DM DALYs than females, though a greater increase was observed among males.ConclusionOverall, T2DM related mortality was higher among females. Compared to in HIC, there appeared to be a considerable increase in the burden of T2DM in MIC and LIC, where BMI is the leading risk factor for T2DM-related mortality. Prevention programs should emphasize related risk factors according to the existing standard of care.

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“…These antibodies are present in the CSF of T1DM patients [ 112 – 115 ]. Up to 2–3.7% of patients with T1DM have epilepsy, and patients with type I diabetes have up to six times the increased risk for epilepsy [ 116 ].…”

Section: Systemic Inflammationmentioning

confidence: 99%

The role of inflammation in the development of epilepsy

Rana

Musto

2018

J Neuroinflammation

511

328

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Epilepsy, a neurological disease characterized by recurrent seizures, is often associated with a history of previous lesions in the nervous system. Impaired regulation of the activation and resolution of inflammatory cells and molecules in the injured neuronal tissue is a critical factor to the development of epilepsy. However, it is still unclear as to how that unbalanced regulation of inflammation contributes to epilepsy. Therefore, one of the goals in epilepsy research is to identify and elucidate the interconnected inflammatory pathways in systemic and neurological disorders that may further develop epilepsy progression. In this paper, inflammatory molecules, in neurological and systemic disorders (rheumatoid arthritis, Crohn’s, Type I Diabetes, etc.) that could contribute to epilepsy development, are reviewed.Understanding the neurobiology of inflammation in epileptogenesis will contribute to the development of new biomarkers for better screening of patients at risk for epilepsy and new therapeutic targets for both prophylaxis and treatment of epilepsy.

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Chronic comorbidities in children with type 1 diabetes: a population-based cohort study

Abstract: Our longitudinal study showed that incidences of six chronic diseases were significantly higher in T1D children during the early years of developing this disease compared with the reference children.

Cited by 29 publications

References 39 publications

Multimorbidity patterns of oral clinical conditions, social position, and oral health-related quality of life in a population-based survey of 12-yr-old children

Multimorbidity patterns of oral clinical conditions, social position, and oral health-related quality of life in a population-based survey of 12-yr-old children

Sex differences and risk factors for diabetes mellitus - an international study from 193 countries

The role of inflammation in the development of epilepsy

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