2010
DOI: 10.2310/7750.2010.09034
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Chronic Cutaneous Graft-versus-Host Disease Manifesting as Calcinosis Cutis Universalis on a Background of Widespread Sclerodermatoid Changes

Abstract: We report a previously unreported manifestation of chronic cutaneous GVHD, specifically calcinosis cutis universalis on a background of sclerodermoid changes.

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Cited by 9 publications
(6 citation statements)
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“…Sclerotic-type chronic skin graft-versus-host disease shares many clinical features with SS, suggesting a common pathway leading to calcinosis. The 7 cases described herein are similar to 2 previously reported cases in the literature, including a long latency period (12 and 14 years) and antecedent ScGVHD . The lower extremities are a common site of skin sclerosis in ScGVHD and were the most common location for calcinosis in these patients.…”
Section: Discussionsupporting
confidence: 83%
See 1 more Smart Citation
“…Sclerotic-type chronic skin graft-versus-host disease shares many clinical features with SS, suggesting a common pathway leading to calcinosis. The 7 cases described herein are similar to 2 previously reported cases in the literature, including a long latency period (12 and 14 years) and antecedent ScGVHD . The lower extremities are a common site of skin sclerosis in ScGVHD and were the most common location for calcinosis in these patients.…”
Section: Discussionsupporting
confidence: 83%
“…Systemic sclerosis and sclerotic-type chronic skin graft-versus-host disease (ScGVHD) share several clinical and histologic features; however, high-titer antibodies specifically associated with SS are not typically found in ScGVHD, and the fibrotic features in ScGVHD more closely resemble morphea and eosinophilic fasciitis . Whereas calcinosis is well described in SS, there are only 2 reports of calcinosis in the setting of chronic graft-versus-host disease (cGVHD), to our knowledge . We sought to identify patients with cGVHD with calcinosis to explore predisposing factors and clinical features.…”
mentioning
confidence: 99%
“…Calcinosis cutis associated with sclerodermoid GVHD remains an interesting yet rarely discussed topic in the literature (Table 1) [9,10]. In the two previously published cases and in our patient, the patient age was greater than 50 years, serum calcium was normal, the time interval between the initial diagnosis of sclerodermoid GVHD and the development of calcinosis cutis was greater than 10 years (average 11.5 years), and the aetiology of calcification was thought to be dystrophic, related to chronic sclerodermoid change.…”
Section: Discussionmentioning
confidence: 99%
“…Additional signs and symptoms of evolving sclerotic involvement include widespread calcinosis, 91 edema of the affected extremity, muscle weakness, pain, and cramping. 92 It may be clinically difficult to differentiate edema associated with sclerotic skin involvement from drug-induced causes (eg, sirolimus, imatinib, or gabapentin), fluid overload, and deep venous thrombosis in patients with indwelling lines.…”
Section: Sclerotic Manifestations Of Chronic Gvhdmentioning
confidence: 98%