Graft-versus-host disease

Chronic graft-versus-host disease: clinical presentation of multiple lesions of lichenoid and atrophic pattern

“…Involvement of oral mucosa is frequent and may be very relevant affecting the health and quality of life of patients. 2,6 Despite the expressive mucocutaneous and adnexal involvement, no evidence of systemic disease has been detected in this particular patient so far, although this possibility cannot be ruled out during the patient's follow-up .…”

“…4 Chronic GVHD occurs in up to 70% of hematopoietic cell transplanted patients. 2,3 Dermatologists and stomatologists must play an active role in the management and treatment of patients with GVHD, as oral and cutaneous lesions have severe impact on morbidity and quality of life.…”

Anti–Angiotensin Type 1 Receptor Antibodies in Chronic Graft-Versus-Host Disease

“…The production of autoantibodies after HSCT is caused by the lack of peripheral B-cell tolerance against selfantigens, which could be influenced by the high expression of the B-cell activating factor, which inhibits the apoptosis of low affinity autoreactive B cells (3). Whereas the role of antibodies directed against minor (3) or major histocompatibility antigens is recognized (3,13), the role of antibodies commonly seen in autoimmune diseases is still unclear (4).…”

“…Unfortunately, chronic graft-versus-host disease (cGvHD) after HSCT is a serious and potentially life-threatening long term complication (1). Between 50% and 70% of patients develop cGvHD after HSCT (3). Chronic graft-versus-host disease involves complex immunologic phenomena including alloimmunity and autoimmunity, as a result of donor T lymphocyte responses and recipient antigen-presenting cell deregulation leading to tissue inflammation and fibrosis (4).…”

Isomorphic Sclerotic-Type Cutaneous Chronic Graft-Versus-Host Disease: Report and Review of Chronic Graft-Versus-Host Disease in a Cutaneous Immunocompromised District

“…The patients include other men with waistband-associated chronic GVHD and women with brassiere band and/or waistband-related chronic GVHD [1, 2, 11, 14]; of note, similar to the reported patient with isomorphic (waistband) and idiopathic (right forearm and hand) sclerotic-type GVHD, other individuals with concurrent isomorphic chronic cutaneous GVHD and idiopathic sclerotic-type GVHD have been observed [11]. The source of injury associated with isomorphic sclerotic-type GVHD has also been the sites of injections of subcutaneous interferon alpha on the abdomen [15], previous subclavian or central venous catheter placement without [14] or with [11] subsequent cellulitis, repeated needle sticks to obtain blood from the right antecubital fossa [11], suction blisters [16], and Bacillus Calmette Guerin therapy [16].…”