1990
DOI: 10.1097/00007890-199006000-00013
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Chronic Cyclosporine-Associated Nephrotoxicity in Bone Marrow Transplant Patients

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Cited by 49 publications
(21 citation statements)
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“…55,56 Reported risk factors for CKD after HCT are sex, age, previous renal impairment, type of HCT (autologous vs allogeneic), TBI exposure, acute or chronic GVHD, development of VOD, post transplant exposure to nephrotoxic medications (aminoglycosides, amphotericin B and vancomycin), post transplant hypertension, post-HCT AKI and long-term use of CYA; the most common causes of CKD following HCT are chronic CYA nephrotoxicity and thrombotic microangiopathy. 53,[57][58][59][60][61][62][63] Chronic CYA therapy can cause nephrotoxicity similar to that seen in other settings, such as solid organ transplantation. Long-term complications are, however, unusual in HCT because CYA is given in full doses to stable patients for only several months.…”
Section: 41mentioning
confidence: 93%
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“…55,56 Reported risk factors for CKD after HCT are sex, age, previous renal impairment, type of HCT (autologous vs allogeneic), TBI exposure, acute or chronic GVHD, development of VOD, post transplant exposure to nephrotoxic medications (aminoglycosides, amphotericin B and vancomycin), post transplant hypertension, post-HCT AKI and long-term use of CYA; the most common causes of CKD following HCT are chronic CYA nephrotoxicity and thrombotic microangiopathy. 53,[57][58][59][60][61][62][63] Chronic CYA therapy can cause nephrotoxicity similar to that seen in other settings, such as solid organ transplantation. Long-term complications are, however, unusual in HCT because CYA is given in full doses to stable patients for only several months.…”
Section: 41mentioning
confidence: 93%
“…However, the characteristic vascular and interstitial changes of CYA nephrotoxicity, such as obliterative arteriolopathy, ischaemic collapse or scarring of the glomeruli, vacuolization of the tubules, global and focal segmental glomerulosclerosis, and focal areas of tubular atrophy and interstitial fibrosis (producing a picture of 'striped' fibrosis) can occur with prolonged therapy for GVHD. 63 The factors responsible for chronic CYA nephrotoxicity are not well understood. The development of interstitial fibrosis is associated with increased expression of osteopontin, 64 chemokines 65 and transforming growth factor-b.…”
Section: 41mentioning
confidence: 99%
“…5 After allogeneic BMT the nephrotoxicity of cyclosporin A and chronic GVHD also need to be considered. 20,21 Although chronic renal impairment in children was described at an early date, to our knowledge, only one pediatric study has focused on its long-term development (after allogeneic BMT). [9][10][11]13,22 Hence, little is known about whether the renal damage that is evident within the first year after BMT leads to progressive loss of renal function or to ultimate stabilization.…”
mentioning
confidence: 99%
“…RF, in the absence of identifiable causes, develops at a median of 9 months (4.5-26 months) following APSCT [19]. Additional causes of chronic RF in patients post-APSCT include radiation induced RF [20,21], cyclosporine, cyclophosphamide and iphosphamide-induced nephrotoxicity [22][23][24] and subacute or chronic microangiopathy [25,26].…”
Section: Discussionmentioning
confidence: 99%