Chronic dietary toxicity of zinc oxide nanoparticles in common carp (Cyprinus carpio L.): Tissue accumulation and physiological responses

Chupani, Latifeh; Niksirat, Hamid; Velíšek, Josef; Stará, Alžběta; Hradilová, Šárka; Kolařík, J; Panáček, Aleš; Zusková, Eliška

doi:10.1016/j.ecoenv.2017.08.024

Cited by 93 publications

(35 citation statements)

References 22 publications

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“…Despite their useful properties, nanoparticle hazards on the biological system are poorly understood up till now [ 1 – 3 ]. The wide production and huge use of nanoparticles facilitate their possibility to induce hazards, for example, the use of nanoparticles in water waste treatment leads to their spread in the aquatic environment inducing a huge hazard for both human and aquatic beings [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress in the Muscles of the Fish Nile Tilapia Caused by Zinc Oxide Nanoparticles and Its Modulation by Vitamins C and E

Abdelazim

Saadeldin

Swelum

et al. 2018

Oxidative Medicine and Cellular Longevity

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The effects of zinc oxide nanoparticles (ZnONPs) on antioxidants in Nile tilapia muscles and the protective role of vitamins C and E were examined. Two hundred males of Nile tilapia were held in aquaria (10 fishes/aquarium). Fishes were divided into 5 groups: 40 fishes in each group; the first group was the control; the 2nd and 3rd groups were exposed to 1 and 2 mg/L of ZnONPs, respectively; and the 4th and 5th group were exposed to 1 and 2 mg/L of ZnONPs and treated with a (500 mg/kg diet) mixture of vitamin C and E mixture (250 mg/kg diet of each). Muscles were collected on the 7th and 15th day of treatments. Muscle malondialdehyde, reduced glutathione levels, superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GR), glutathione peroxidase (GPx), and glutathione-S-transferase (GST) activities were measured after treatments. Relative quantification of SOD, CAT, GR, GPx, and GST mRNA transcripts was detected in the muscles. Results showed that MDA and GSH concentration; SOD, CAT, GR, GPx, and GST activities; and mRNA expression were significantly decreased in groups exposed to ZnONPs. Vitamins C and E significantly ameliorated the toxic effects of ZnONPs. In conclusion, vitamins C and E have the ability to ameliorate ZnONP oxidative stress toxicity in Nile tilapia.

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Section: Introductionmentioning

confidence: 99%

Oxidative Stress in the Muscles of the Fish Nile Tilapia Caused by Zinc Oxide Nanoparticles and Its Modulation by Vitamins C and E

Abdelazim

Saadeldin

Swelum

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…Chupani et al investigated the relationship of ZnO NPs supplied with food by studying common carp (Cyprinus carpio). The authors analyzed their blood, using methods such as erythrocyte count, leukocyte count, hematocrit, hemoglobin, mean blood hemoglobin, mean blood volume, glucose, triglycerol and cholesterol, total proteins, aspartate aminotransferase and alanine aminotransferase [117]. Despite exceeding the limit values for some parameters, no effects on hematology, blood biochemistry or lipid peroxidation levels were found during the exposure period.…”

Section: Penetration Of Nanoparticles Through the Circulatory Systemmentioning

confidence: 99%

Analysis of the Exposure of Organisms to the Action of Nanomaterials

et al. 2020

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The rapid development of the production of materials containing metal nanoparticles and metal oxides is a potential risk to the environment. The degree of exposure of organisms to nanoparticles increases from year to year, and its effects are not fully known. This is due to the fact that the range of nanoparticle interactions on cells, tissues and the environment requires careful analysis. It is necessary to develop methods for testing the properties of nanomaterials and the mechanisms of their impact on individual cells as well as on entire organisms. The particular need to raise public awareness of the main sources of exposure to nanoparticles should also be highlighted. This paper presents the main sources and possible routes of exposure to metal nanoparticles and metal oxides. Key elements of research on the impact of nanoparticles on organisms, that is, in vitro tests, in vivo tests and methods of detection of nanoparticles in organisms, are presented.

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“…As a result, the hazard and risk assessment of NPs is key to ensure their safe use for humans and the environment. So far, in vivo studies have been the main source of information regarding NP effects on the physiology of biological organisms [ 20 , 21 , 22 ]. Furthermore, the requirements for a reduction in animal testing as per the 3Rs (Replace, Reduce, Refine) principles [ 23 ] and European Commission (EC) legislation [ 24 ] have led to a push for development of alternative testing strategies (ATS).…”

Section: Introductionmentioning

confidence: 99%

Predicting Cytotoxicity of Metal Oxide Nanoparticles Using Isalos Analytics Platform

et al. 2020

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A literature curated dataset containing 24 distinct metal oxide (MexOy) nanoparticles (NPs), including 15 physicochemical, structural and assay-related descriptors, was enriched with 62 atomistic computational descriptors and exploited to produce a robust and validated in silico model for prediction of NP cytotoxicity. The model can be used to predict the cytotoxicity (cell viability) of MexOy NPs based on the colorimetric lactate dehydrogenase (LDH) assay and the luminometric adenosine triphosphate (ATP) assay, both of which quantify irreversible cell membrane damage. Out of the 77 total descriptors used, 7 were identified as being significant for induction of cytotoxicity by MexOy NPs. These were NP core size, hydrodynamic size, assay type, exposure dose, the energy of the MexOy conduction band (EC), the coordination number of the metal atoms on the NP surface (Avg. C.N. Me atoms surface) and the average force vector surface normal component of all metal atoms (v⊥ Me atoms surface). The significance and effect of these descriptors is discussed to demonstrate their direct correlation with cytotoxicity. The produced model has been made publicly available by the Horizon 2020 (H2020) NanoSolveIT project and will be added to the project’s Integrated Approach to Testing and Assessment (IATA).

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Chronic dietary toxicity of zinc oxide nanoparticles in common carp (Cyprinus carpio L.): Tissue accumulation and physiological responses

Cited by 93 publications

References 22 publications

Oxidative Stress in the Muscles of the Fish Nile Tilapia Caused by Zinc Oxide Nanoparticles and Its Modulation by Vitamins C and E

Oxidative Stress in the Muscles of the Fish Nile Tilapia Caused by Zinc Oxide Nanoparticles and Its Modulation by Vitamins C and E

Analysis of the Exposure of Organisms to the Action of Nanomaterials

Predicting Cytotoxicity of Metal Oxide Nanoparticles Using Isalos Analytics Platform

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