Chronic Eosinophilic Pneumonia in a One-Year-Old Child

Rao, Madu; Steiner, Phillip; Rose, Jeyanth Suresh; Kassner, E. George; Kottmeier, Peter K.; Steiner, Morris

doi:10.1378/chest.68.1.118

Cited by 19 publications

(12 citation statements)

References 7 publications

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“…To date, only ten pediatric observations have been reported in the literature [8-14], apart from those published by our center [15-17], with no follow-up studies or series (Table 6). Diagnosis in children has relied on adult criteria [3], as used in this study.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic eosinophilic pneumonia in children: the French experience

Giovannini‐Chami

Hadchouel

Nathan

et al. 2014

Orphanet J Rare Dis

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BackgroundIdiopathic eosinophilic pneumonia is extremely rare in children and adults. We present herein the first series describing the specificities of idiopathic chronic (ICEP) and acute (IAEP) eosinophilic pneumonia in children.MethodsWe retrospectively analyzed all cases of ICEP and IAEP in children that were retrieved from French Reference Centers for rare pediatric lung diseases.ResultsFive cases of pediatric ICEP were identified. Corticosteroid or immunosuppressive therapy dramatically improved the outcome in three cases. The remaining two cases had a persistent interstitial pattern with progressive development of cystic airspace lesions. Three cases of IAEP in adolescents were reported, with one requiring four days of extracorporeal membrane oxygenation.ConclusionICEP is a rare disease with a polymorphic clinical presentation in children. We identified patients with persistent interstitial patterns progressing to cystic airspace regions, for which the boundaries with idiopathic interstitial pneumonias are difficult to establish. We therefore propose a specific pediatric definition and classification algorithm. IAEP in children remains an inflammatory reaction of the lung to an acute toxic exposure, mainly tobacco, as in adults. International studies are required to comprehensively assess the various clinical forms of the disease as well as the appropriate therapeutic regimens.

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Section: Discussionmentioning

confidence: 99%

Idiopathic eosinophilic pneumonia in children: the French experience

Giovannini‐Chami

Hadchouel

Nathan

et al. 2014

Orphanet J Rare Dis

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“…CEP may affect every age group, with a mean age at presentation of 45 years. It is extremely rare in childhood 7–9. This is the first reported case of chronic eosinophilic pneumonia presenting with mucous plugs in children described to date in the literature.…”

Section: Discussionmentioning

confidence: 84%

“…Asthma (chronic eosinophilic bronchitis), allergic bronchopulmonary aspergillosis, simple pulmonary eosinophilia (parasitic infections and drug reactions), eosinophilic vasculitis, and eosinophilic pneumonia (acute, chronic, and drug induced) are the most common pulmonary eosinophilic syndromes 1–6. Chronic eosinophilic pneumonia (CEP) is an extremely rare disease in childhood 7–9. We report a CEP with eosinophilic mucous plugs in a 7‐year‐old girl who presented with respiratory symptoms and typical radiological findings.…”

Section: Introductionmentioning

confidence: 98%

Chronic eosinophilic pneumonia with mucous plugs in a child

Çakır

Aksoy

Cakir³

et al. 2010

Pediatric Pulmonology

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Chronic eosinophilic pneumonia is a rare cause of chronic lung disease in children. A 7-year-old girl who attended our clinics with cough and sputum lasting for 5 years, has been evaluated for bilateral alveolar infiltration and ground-glass opacities. Peripheral eosinophilia was detected in total cell blood count. Flexible bronchoscopy showed mucous plugs. Bronchoalveolar lavage fluid and cell block of mucous plugs determined hypereosinophilia. Chronic eosinophilic pneumonia was confirmed after the elimination of other eosinophilic lung diseases and the case was accepted to be idiopathic. She showed a dramatic response to oral corticosteroids. This is the first reported case of chronic eosinophilic pneumonia presenting with mucous plugs in children described to date in the literature.

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“…Described by Carrington et al in 1969, ICEP has been first described in childhood in 1975 in a 1-year-old infant 1. To date, only 10 paediatric observations have been reported in the literature with no follow-up studies or series 1–8.…”

Section: Discussionmentioning

confidence: 99%

Chronic eosinophilic pneumonia with persistent decreased diffusing capacity for carbon monoxide

et al. 2013

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SUMMARYWe report a 15-year-old girl presenting with dry cough, exertional dyspnoea, weight loss, fever and night sweats for over 1 month. Blood tests revealed hypereosinophilia, high IgE and antinuclear antibodies levels. Chest x-rays showed bilateral peripheral infiltrates mostly in the right upper lobe which was confirmed by a chest CT. Bronchoalveolar lavage showed hypercellularity with 28% of eosinophils. Idiopathic chronic eosinophilic pneumonia was confirmed after exclusion of other causes of eosinophilic pneumonia and systemic disease. The patient responded dramatically to oral corticosteroids. Oral corticotherapy was stopped after 4 months. At 8 months of follow-up, diffusing capacity for carbon monoxide (DLCO) remained moderately low (58%) with persistent mild exertional dyspnoea. Cardiopulmonary exercise testing showed muscular peripheral limitation. Even if in our patient, mild exertional dyspnoea can be partly correlated to peripheral deconditioning, DLCO should be systematically evaluated to determine follow-up studies standards, to correlate with subclinical disease, relapse risk and to codify therapeutic options. BACKGROUND

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Chronic Eosinophilic Pneumonia in a One-Year-Old Child

Cited by 19 publications

References 7 publications

Idiopathic eosinophilic pneumonia in children: the French experience

Idiopathic eosinophilic pneumonia in children: the French experience

Chronic eosinophilic pneumonia with mucous plugs in a child

Chronic eosinophilic pneumonia with persistent decreased diffusing capacity for carbon monoxide

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