Chronic Ethanol Consumption Alters All‐<i>Trans</i>‐Retinoic Acid Concentration and Expression of Their Receptors on the Prostate: A Possible Link Between Alcoholism and Prostate Damage

Fontanelli, Beatriz Aparecida Fioruci; Chuffa, Luiz Gustavo de Almeida; Teixeira, Giovana Rampazzo; Amorim, João Paulo de Arruda; Mendes, Leonardo O.; Pinheiro, Patrícia Fernanda Felipe; Kurokawa, Cilmery Suemi; Pereira, Sérgio Luís da Silva; Fávaro, Wagner José; Martins, Otávio Augusto; Júnior, Wílson de Mello; Martinez, Marcelo; Júnior, Antonio Rugolo; Martinez, Francisco Eduardo

doi:10.1111/j.1530-0277.2012.01866.x

Cited by 8 publications

(7 citation statements)

References 47 publications

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“…The RA biosynthetic pathway is likely to be suppressed or activated depending on the local prostate microenvironment [146][147][148] . The effect of RA has been investigated in normal and malignant prostate tissues [129,149] .…”

Section: Aldhs and The Retinoid Signalling Pathwaymentioning

confidence: 99%

Expression and regulation of aldehyde dehydrogenases in prostate cancer

Ibrahim¹,

Sadiq²,

Frame³

et al. 2018

JCMT

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The functional role of aldehyde dehydrogenases (ALDHs) in prostate cancer remains an area of some controversy. Many studies have used high ALDH functional activity to isolate putative cancer stem cells with tumour-initiating and propagating properties, while evidence is also emerging about the involvement of specific isoforms in migration, invasiveness and metastasis. Identification of specific ALDH isoforms, which contribute to both drug resistance and aggressiveness of the disease remains a challenge within the complex heterogeneity of prostate cancer. The purpose of this perspective is to dissect functional roles for ALDH in the tumour microenvironment and to evaluate the potential of the ALDH gene family as biomarkers and/or targets for therapeutic intervention. ABSTRACTArticle history:

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Section: Aldhs and The Retinoid Signalling Pathwaymentioning

confidence: 99%

Expression and regulation of aldehyde dehydrogenases in prostate cancer

Ibrahim¹,

Sadiq²,

Frame³

et al. 2018

JCMT

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“…3,4 The effects of ethanol have been better understood with the use of ethanol-preferring animals (e.g., UChB) that derived from original Wistar rats and have been selectively bred at the University of Chile for almost 70 generations. 5 This rat represents a special model for studying the relationship among the genetic, biochemical, physiologic, nutritional, and pharmacological factors arising from alcoholism, such as those found in alcohol-related human diseases.…”

Section: Introductionmentioning

confidence: 99%

Testosterone Therapy Differently Regulates the Anti‐ and Pro‐Inflammatory Cytokines in the Plasma and Prostate of Rats Submitted to Chronic Ethanol Consumption (UChB)

Mendes

Scarano

Rochel-Maia³

et al. 2014

American J Rep Immunol

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“…Retinoic acids (RAs) are a group of natural and synthetic derivatives of vitamin A that are known to play a crucial role in cell proliferation, differentiation, and maintenance of the homeostasis of the prostate [ 4 , 5 ]. RAs have various stereoisomers, including all-trans-RA (ATRA), 9-cis-RA (alitretinoin), and 13-cis-RA (isotretinoin).…”

Section: Introductionmentioning

confidence: 99%

Macrophages are targets of retinoic acid signaling during the wound-healing process after thulium laser resection of the prostate

Wang

Shi³

et al. 2017

Oncotarget

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BACKGROUNDThe wound-healing process is very important for reducing complications after thulium laser resection of the prostate (TmLRP). The retinoic acid (RA) signaling pathway has been well studied in the wound-healing process of the skin and other organs. The goals of this study were to identify the role of RA signaling in the repair of the prostate after TmLRP and to investigate the molecular mechanism of this process.RESULTSRetinoic acid receptors (RARs) were present in the prostate, and their expression was increased after TmLRP. RARβ was expressed in the macrophages and may be related to the role of stromal cells in the wound-healing process. In vitro, RA enhanced the function of anti-inflammatory macrophages and promoted stromal cell activation and angiogenesis. Arg1 was also increased via RARβ after treatment with RA.MATERIALS AND METHODSThe expression of RARs was analyzed in vivo by immunohistochemistry (IHC), real time qPCR, and western blot analysis. THP-1 cells were co-treated with or without RA and stimulating factor and then assessed by ELISA and qPCR. The supernatants from these cells were cultured with stromal cells and vascular endothelial cells, and the effects on these cells were analyzed.CONCLUSIONSWe found that RA signaling was involved in the wound-healing process of the prostate after TmLRP. RA treated macrophages activated stromal cells and promoted angiogenesis. RARβ was the key isoform in this process.

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Chronic Ethanol Consumption Alters All‐Trans‐Retinoic Acid Concentration and Expression of Their Receptors on the Prostate: A Possible Link Between Alcoholism and Prostate Damage

Cited by 8 publications

References 47 publications

Expression and regulation of aldehyde dehydrogenases in prostate cancer

Expression and regulation of aldehyde dehydrogenases in prostate cancer

Testosterone Therapy Differently Regulates the Anti‐ and Pro‐Inflammatory Cytokines in the Plasma and Prostate of Rats Submitted to Chronic Ethanol Consumption (UChB)

Macrophages are targets of retinoic acid signaling during the wound-healing process after thulium laser resection of the prostate

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