Chronic ethanol ingestion and the risk of acute lung injury: a role for glutathione availability?

Brown, Lou Ann S.; Harris, Frank L.; Ping, Xiao-Du; Gauthier, Theresa W.

doi:10.1016/j.alcohol.2004.08.002

Cited by 98 publications

(98 citation statements)

References 31 publications

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“…AMs phagocytose and clear infectious particles from the lower airways (8), and chronic ethanol consumption impairs AM bacterial phagocytosis (9), increasing the risk for lung infection and injury (9,10). Although the mechanisms are incompletely defined, several studies have provided important mechanistic insights for the deleterious effects of alcohol on AM phagocytosis.…”

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confidence: 99%

Peroxisome Proliferator–Activated Receptor γ Regulates Chronic Alcohol-Induced Alveolar Macrophage Dysfunction

Yeligar

Mehta

Harris

et al. 2016

Am J Respir Cell Mol Biol

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Peroxisome proliferator-activated receptor (PPAR) g is critical for alveolar macrophage (AM) function. Chronic alcohol abuse causes AM phagocytic dysfunction and susceptibility to respiratory infections by stimulating nicotinamide adenine dinucleotide oxidases (Nox), transforming growth factor-b 1 , and oxidative stress in the AM. Because PPARg inhibits Nox expression, we hypothesized that alcohol reduces PPARg, stimulating AM dysfunction. AMs were examined from: (1) patients with alcoholism or control patients; (2) a mouse model of chronic ethanol consumption; (3) PPARg knockout mice; or (4) MH-S cells exposed to ethanol in vitro. Alcohol reduced AM PPARg levels and increased Nox1, -2, and -4, transforming growth factor-b 1 , oxidative stress, and phagocytic dysfunction. Genetic loss of PPARg recapitulated, whereas stimulating PPARg activity attenuated alcohol-mediated alterations in gene expression and phagocytic function, supporting the importance of PPARg in alcohol-induced AM derangements. Similarly, PPARg activation in vivo reduced alcohol-mediated impairments in lung bacterial clearance. Alcohol increased levels of microRNA-130a/-301a, which bind to the PPARg 39 untranslated region to reduce PPARg expression. MicroRNA-130a/-301a inhibition attenuated alcohol-mediated PPARg reductions and derangements in AM gene expression and function. Alcohol-induced Toll-like receptor 4 endocytosis was reversed by PPARg activation. These findings demonstrate that targeting PPARg provides a novel therapeutic approach for mitigating alcohol-induced AM derangements and susceptibility to lung infection.

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confidence: 99%

Peroxisome Proliferator–Activated Receptor γ Regulates Chronic Alcohol-Induced Alveolar Macrophage Dysfunction

Yeligar

Mehta

Harris

et al. 2016

Am J Respir Cell Mol Biol

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“…A significant increased level of vitamin A and E in the liver and kidney of rats induced with ammonium metavanadate toxicity by the prior treatment with green tea was reported by Soussi et al [20]. The GSH is a powerful nucleophile, critical for cellular protection nucleophile, critical for cellular protection such as detoxification from reactive oxygen species, conjugation and excretion of toxic molecules, and control of the inflammatory cytokine cascade [21]. Bigoniya and Rana [22] reported that saponin fraction of Euphorbia neriifolia has increased the levels of hepatic GSH in CCl 4 induced hepatotoxicity in rats.…”

Section: Discussionmentioning

confidence: 99%

Anticancer Activity of Plant Protein Against Dalton’s Lymphoma Ascites Tumor Cell Lines

Srilatha¹,

Santhi²,

Annapurani³

2016

Asian J Pharm Clin Res

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Objective: Tabernaemontana divaricata (Td) is commonly used plants for the treatment of inflammatory, anticancer, and diabetics. The main objective of this study is to assess the antitumor and antioxidant activity of Td in mice model. Methods:Antitumor activity of TdPf extract (52 µg/ml) is evaluated against Dalton's lymphoma ascites (DLA) tumor mice. After 24 hrs of tumor inoculation, the extract is administered daily for 15 and 60 days. After administration of the lost dose followed by 18 hrs fasting, mice are sacrificed for observation of antitumor activity. Antitumor activity is assessed by monitoring the liver marker enzyme, lipid peroxidation effect on antioxidant enzyme levels, and histopathological evidence. Results:The results showed that the protein extract of Td animals restored the antioxidant enzymes when compared to the mice of the DLA control group. Conclusion:The findings indicate that the extract of plant protein has antitumor activity by preventing the lipid peroxidation and thereby promoting the antioxidant systems in DLA induced mice. And hence, it is evident that these extract could be a natural anticancer agent for the human health.

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“…72,76 Decreased levels of glutathione have been observed in pulmonary macrophages, and glutathione repletion improves bacterial clearance. [77][78][79] Adaptive immunity also is impaired. fests as agitation, but some patients present with vegetative symptoms rather than agitation.…”

Section: Management Of Sedationmentioning

confidence: 99%

Alcohol-Use Disorders in the Critically Ill Patient

Wit

Jones

Sessler

et al. 2010

Chest

100

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A lcohol-use disorders (AUDs) encompass a spectrum of disorders, including excessive use, abuse, dependence, and addiction. Abuse occurs when a patient experiences adverse socioeconomic or health consequences related to the use of the substance. 1 Dependence is present either when the patient experiences withdrawal symptoms on discontinuation of the substance or when larger amounts are necessary to achieve the desired effect. 1 Addiction is indicated by the patient experiencing a compulsive craving for a substance. 1 At any one time, a patient may have more than one of these disorders simultaneously present. The National Institutes of Health 2 have put forth guidelines that quantify excessive and unhealthy use of alcohol; a level of use above this threshold increases a patient's risk for health problems. 3 Men aged Յ 65 years who consume more than four standard drinks in a typical day or . 14 standard drinks in a typical week have excessive and unhealthy alcohol consumption. These volumes are halved for women of all ages and men aged .

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Chronic ethanol ingestion and the risk of acute lung injury: a role for glutathione availability?

Cited by 98 publications

References 31 publications

Peroxisome Proliferator–Activated Receptor γ Regulates Chronic Alcohol-Induced Alveolar Macrophage Dysfunction

Peroxisome Proliferator–Activated Receptor γ Regulates Chronic Alcohol-Induced Alveolar Macrophage Dysfunction

Anticancer Activity of Plant Protein Against Dalton’s Lymphoma Ascites Tumor Cell Lines

Alcohol-Use Disorders in the Critically Ill Patient

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