Chronic exposure of zinc oxide nanoparticles causes deviant phenotype in Drosophila melanogaster

Anand, Avnika Singh; Prasad, Dipti; Singh, Shashi Bala; Kohli, Ekta

doi:10.1016/j.jhazmat.2016.12.040

Cited by 48 publications

(24 citation statements)

References 35 publications

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“…Exposure to various types of nanoparticles (Ag, TiO 2 , Co, Au, ZnO, zirconia, and hydroxyapatite nanoparticles) is known to cause aberrant phenotypes with aberration observed in the wings, bristles, thorax, abdomen, eyes, cuticle development, and pigmentation 36 . While some of these aberrations are caused by mutations and are passed down onto successive generations 35,37 not all of them are inheritable. In a Drosophila model, nanoparticles can also cause somatic mutations 38,39 , induce alteration in a signaling pathway 40 resulting in a defective adult fly 36 , or cause developmental abnormalities 41,42 , any of which may be responsible for the aberrations observed.…”

Section: Discussionmentioning

confidence: 99%

The effects of a human food additive, titanium dioxide nanoparticles E171, on Drosophila melanogaster - a 20 generation dietary exposure experiment

Jovanović

Cvetković

et al. 2018

Sci Rep

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In this study, fruit flies (Drosophila melanogaster) were exposed to an estimated daily human E171 consumption concentration for 20 generations. Exposure to E171 resulted in: a change in normal developmental and reproductive dynamics, reduced fecundity after repetitive breeding, increased genotoxicity, the appearance of aberrant phenotypes and morphologic changes to the adult fat body. Marks of adaptive evolution and directional selection were also exhibited. The larval stages were at a higher risk of sustaining damage from E171 as they had a slower elimination rate of TiO2 compared to the adults. This is particularly worrisome, since among the human population, children tend to consume higher daily concentrations of E171 than do adults. The genotoxic effect of E171 was statistically higher in each subsequent generation compared to the previous one. Aberrant phenotypes were likely caused by developmental defects induced by E171, and were not mutations, since the phenotypic features were not transferred to any progeny even after 5 generations of consecutive crossbreeding. Therefore, exposure to E171 during the early developmental period carries a higher risk of toxicity. The fact that the daily human consumption concentration of E171 interferes with and influences fruit fly physiological, ontogenetic, genotoxic, and adaptive processes certainly raises safety concerns.

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Section: Discussionmentioning

confidence: 99%

The effects of a human food additive, titanium dioxide nanoparticles E171, on Drosophila melanogaster - a 20 generation dietary exposure experiment

Jovanović

Cvetković

et al. 2018

Sci Rep

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“…Increased oxidative load with increasing concentration of ZnO NPs clearly indicates towards oxidative stress triggered by these NPs. In addition, this study has clearly shown that ZnO NPs cause phenotypic abnormalities, which might be transmitted to the progeny, while no phenotypic abnormality was reported in parent flies [18]. The genotoxic potential of ZnO NPs has been demonstrated in ovary cells of Chinese hamsters, by chromosome aberration test [19], in a human epidermal cell line [20], in primary human epidermal keratinocytes [21] and in human liver cells [22] by comet assay and in the human carcinoma cell line by comet and micronucleus assays [23].…”

Section: Discussionmentioning

confidence: 63%

The Healing Effect of Cimin Grape Against Toxic Effects of ZnOTiO₂ Nanocomposite

ATICI

Çolak

2017

Acta Phys. Pol. A

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Today, occurrence of nanotechnology is making life easier, increasing the individual happiness and attracts attention to the benefits to be provided by it. As with any technology, nanotechnology also has risks, which are discussed here. In this study, toxic effects of ZnOTiO2 nanocomposite on various growth parameters of Drosophila melanogaster and removal of these effects by Cimin grape (Vitis vinifera L. ssp., Cimin) were investigated. For this purpose, assessment of the number of offspring and the survival rate were performed by feeding flies with ZnOTiO2 (1 mg/ml) and Cimin grape seed and fruit extracts (5 and 10 mg/ml). In the first stage, larvae of the the same age were put into the medium of each application group and the adult individuals were recorded. In the second stage, in order to determine the number of offspring in all treatment groups, in a set of experiments the grape extracts and ZnOTiO2 were only applied to the female members, while in another set of experiments, the grape extracts and ZnOTiO2 were applied only to male members, belonging to the same application group. The total number of flies developed from the eggs laid during ten days of pair mating was counted. As a result, survival rate and the offspring number in the application groups, that were only exposed to ZnOTiO2 were found to show a decline, compared with the other groups. At the same time, the values obtained from the groups, exposed to the ZnOTiO2 and grape extracts together, were close to control group values. This result supports the healing effects of Cimin grape, which is abundant in Erzincan.

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“…Toxicity of ENMs has been observed in multiple animal models. For example, compared to control, decreased viability and transgenerational toxicity have been observed in D. melanogaster after ingestion of various ENMs (Anand et al, 2017;Raj et al, 2017), genotoxicity and increase in reactive oxygen species (ROS) in C. elegans (Gonzalez-Moragas et al, 2017;Kong et al, 2017;Rogers et al, 2015), and genotoxicity, developmental toxicity, and lung injury in rodents (Duke et al, 2017;Ho et al, 2017;Rahman et al, 2017;Wan et al, 2017;. A challenge in developing toxicity profiles is that novel ENMs can be developed quickly; therefore, ENM toxicity profiling must include predictive models that can link ENM characteristics with their toxicity.…”

Section: Introductionmentioning

confidence: 99%

Multivariate modeling of engineered nanomaterial features associated with developmental toxicity

Truong

Edwards

et al. 2019

NanoImpact

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Despite the increasing prevalence of engineered nanomaterials (ENMs) in consumer products, their toxicity profiles remain to be elucidated. ENM physicochemical characteristics (PCC) are known to influence ENM behavior, however the mechanisms of these effects have not been quantified. Further confounding the question of how the PCC influence behavior is the inclusion of structural and molecular descriptors in modeling schema that minimize the effects of PCC on the toxicological endpoints. In this work, we analyze ENM physico-chemical measurements that have not previously been studied within a developmental toxicity framework using an embryonic zebrafish model. In testing a panel of diverse ENMs to build a consensus model, we found nonlinear relationships between any singular PCC and bioactivity. By using a machine learning (ML) method to characterize the information content of combinatorial PCC sets, we found that concentration, surface area, shape, and polydispersity can accurately capture the developmental toxicity profile of ENMs with consideration to whole-organism effects.

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Chronic exposure of zinc oxide nanoparticles causes deviant phenotype in Drosophila melanogaster

Cited by 48 publications

References 35 publications

The effects of a human food additive, titanium dioxide nanoparticles E171, on Drosophila melanogaster - a 20 generation dietary exposure experiment

The effects of a human food additive, titanium dioxide nanoparticles E171, on Drosophila melanogaster - a 20 generation dietary exposure experiment

The Healing Effect of Cimin Grape Against Toxic Effects of ZnOTiO₂ Nanocomposite

Multivariate modeling of engineered nanomaterial features associated with developmental toxicity

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Chronic exposure of zinc oxide nanoparticles causes deviant phenotype in Drosophila melanogaster

Cited by 48 publications

References 35 publications

The effects of a human food additive, titanium dioxide nanoparticles E171, on Drosophila melanogaster - a 20 generation dietary exposure experiment

The effects of a human food additive, titanium dioxide nanoparticles E171, on Drosophila melanogaster - a 20 generation dietary exposure experiment

The Healing Effect of Cimin Grape Against Toxic Effects of ZnOTiO2 Nanocomposite

Multivariate modeling of engineered nanomaterial features associated with developmental toxicity

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Product

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The Healing Effect of Cimin Grape Against Toxic Effects of ZnOTiO₂ Nanocomposite