Chronic exposure to anaesthetics: A toxicity problem?

Jenkins, Leonard C.

doi:10.1007/bf03025569

Cited by 9 publications

(1 citation statement)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Linde and Bruce reported peak concentrations of 50 ppm halothane around the anesthesiologist (19), while Askrog and Peterson indicated that up to 85 ppm halothane was detected near the anesthesiologist when a nonrebreathing system was used (23). In modern, well ventilated operating rooms, 5-15 ppm halothane could still be detected in the ambient air of the operating room (21)(22)(23)(24)(25). Increased concern was generated in the effects of chronic exposure to low levels of anesthetics, in particular, halothane (13,18,19,21,(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35).…”

mentioning

confidence: 99%

Pathologic changes following chronic exposures to halothane: a review.

Chang¹

1977

Environ Health Perspect

View full text Add to dashboard Cite

The toxic effects of halothane on the liver, kidney, and brain are reviewed. Increasing evidence has indicated that hepatic degeneration can be induced in several animal species after exposure to halothane. Recent electron microscopic investigations have also revealed cytological degeneration of the liver cells after chronic exposure to subclinical levels of halothane. Degeneration of the kidney and the nervous system after halothane exposure have also been reported. The pathological effects of halothane on the neonatal (developing) liver, kidney, and brain are also demonstrated by electron nicroscopy. Although the full significance of these observations on experimental animals in relationship to human exposure is still not known, the indication of the toxic potential of halothane on the biological system is strong and deserves further investigation.

show abstract

mentioning

confidence: 99%

Pathologic changes following chronic exposures to halothane: a review.

Chang¹

1977

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

Behavioral toxicity of anesthetic gases

Synder

Thomas

Gyorky

1978

Annals of Neurology

View full text Add to dashboard Cite

Operating room personnel were studied for evidence of acute reversible or chronic cumulative cognitive dysfunction as measured by psychometric testing. In comparison with matched controls, no acute reversible deficits were noted in a relatively unpolluted operating room environment. There were only 2 marginally significant test differences between the control and operating room groups; however, control subjects did better than operating room personnel on 16 of 18 tests at both the beginning and end of the work week. Analyses of the deficit patterns and correlations with years of operating room exposure only weakly support the hypothesis that the test differences are due to toxic exposure.

show abstract