Chronic exposure to arsenic and high fat diet induces sex-dependent pathogenic effects on the kidney

Yi-xian, Zhang; Young, Jamie L.; Cai, Lu; Tong, Yong Guang; Miao, Lining; Freedman, Jonathan H.

doi:10.1016/j.cbi.2019.06.032

Cited by 21 publications

(12 citation statements)

References 40 publications

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“…A reduction in liver and kidney weight was also observed in females and males of the F0 generation and later in the F2 and F3 generations of the arsenic lineage but only in liver weight. Studies have reported a significant reduction in the weight of the liver 58 and kidneys 59 , 60 of rats and mice exposed to arsenic. In addition to the effect of arsenic on hepato-renal organ somatic indices, a mechanism that could explain the weight loss is that arsenic can contribute to blockage of cellular glucose uptake due to a carbohydrate depletion, promoting that cellular glucose metabolism cannot be ruled out, besides the diverse mechanisms related to an increased risk of diabetes mellitus in animal models 61 .…”

Section: Discussionmentioning

confidence: 99%

Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure

Nava-Rivera

Betancourt-Martínez

Lozoya-Martínez

et al. 2021

Sci Rep

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An emerging concern is the influences of early life exposure to environmental toxicants on offspring characteristics in later life. Since recent evidence suggests a transgenerational transference of aberrant phenotypes from exposed-parents to non-exposed offspring related to adult-onset diseases including reproductive phenotype. The transgenerational potential of arsenic a well know genotoxic and epigenetic modifier agent has not been assessed in mammals until now. In this experimental study, we evaluated the transgenerational effects of arsenic in a rat model with chronic exposure to arsenic. Rats chronically exposed to arsenic in drinking water (1 mg As2O3/mL) (F0) were mated to produce the arsenic lineage (F1, F2, and F3). The arsenic toxic effects on were evaluated over the four generations by analyzing the DNA methylation percentage, genotoxicity in WBC and physical and reproductive parameters, including sperm quality parameters and histopathological evaluation of the gonads. Chronic exposure to arsenic caused genotoxic damage (F0–F3) different methylation patterns, alterations in physical and reproductive parameters, aberrant morphology in the ovaries (F0 and F1) and testicles (F1–F3), and a decrease in the quality of sperm (F0–F3, except F2). Parental chronic arsenic exposure causes transgenerational genotoxicity and changes in global DNA methylation which might be associated with reproductive defects in rats. Combined with recent studies reveal that disturbances in the early life of an individual can affect the health of later generations.

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Section: Discussionmentioning

confidence: 99%

Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure

Nava-Rivera

Betancourt-Martínez

Lozoya-Martínez

et al. 2021

Sci Rep

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“…11 Most studies were focused on the effect of inorganic arsenic over short term duration. 12 Therefore, this study aimed to explore the effects of chronic low dose exposure of or ganic ars enic on the r ats ' kidneys.…”

Section: Introductionmentioning

confidence: 99%

Histopathological Changes in Chronic Low Dose Organic Arsenic Exposure in Rats Kidney

Salahudin¹,

Zamzila²,

Talib³

et al. 2021

imjm

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INTRODUCTION: Exposure to environmental arsenic remains a major public health challenge. Human is exposed to arsenic from groundwater as a result of anthropogenic activities. Chronic exposure to inorganic arsenic has been linked with multiple medical conditions. Therefore, many agricultural countries have shifted the use of inorganic to the organic-based herbicide, monosodium methylarsonate (MSMA). However, with increasing numbers of chronic kidney disease of unknown etiology (CKDu), chronic exposure to herbicide is believed as one of the potential explanations. To date, studies on chronic effects of organic arsenic on the kidney are limited. Therefore, this study aimed to investigate the effect of chronic oral organic arsenic exposure on the rat’s kidney. MATERIALS AND METHOD: Thirty-six Sprague Dawley rats were randomly divided into treatment and its corresponding control groups according to the duration of observations either 2, 4 or 6 months. Both groups were subdivided into three subgroups, each with six animals per subgroup. The treatment groups were given oral MSMA at 63.20 mg/kg body weight, while control groups received distilled water. At the end of each duration, blood was collected for the renal profile, urine for neutrophil gelatinase-associated lipocalin (NGAL) marker, and kidney tissues were harvested for arsenic level measurement and histological analysis. RESULTS:Arsenic level and urinary NGAL were higher in all treatment groups than its corresponding control groups. Histological findings showed progressive pathological changes in the glomeruli and proximal tubules. CONCLUSIONS:Chronic oral exposure to low dose organic arsenic has demonstrated evidence of kidney injury in rats.

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“…It has also been associated with many types of cancer (skin, lung, liver, and bladder) [16]. Nutrition deficiency in woman also found due to arsenic exposure and has been reported in various studies [17][18][19]. However the organic arsenic is less toxic than inorganic arsenic.…”

Section: Introductionmentioning

confidence: 99%

Effects of Arsenic Toxicity on the Environment and Its Remediation Techniques: A Review

Baloch

Talpur

et al. 2020

J. of Wat. & Envir. Tech.

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Contamination of arsenic (As) in water, especially groundwater, has been recognized as a major problem across the world. The presence of arsenic in groundwater has become a global problem in the past decades. Health risks have also been reported for many years. Different areas of the world are affected by arsenic contamination of groundwater, the largest population at risk in Bangladesh, followed by West Bengal in India. Arsenic concentrations in drinking water cause severe health effects on human, more than 150 million people worldwide. The current drinking water standard regulation has become strict and requires a reduction in arsenic content. Therefore, the treatment of arsenic contaminants can be the only effective option to reduce health risks. This review paper briefly describes arsenic sources, arsenic chemistry, arsenic contamination in groundwater, its impact on human health and many conventional as well as advanced techniques that are used to remove arsenic from water.

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Chronic exposure to arsenic and high fat diet induces sex-dependent pathogenic effects on the kidney

Cited by 21 publications

References 40 publications

Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure

Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure

Histopathological Changes in Chronic Low Dose Organic Arsenic Exposure in Rats Kidney

Effects of Arsenic Toxicity on the Environment and Its Remediation Techniques: A Review

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