Chronic exposure to copper oxide nanoparticles causes muscle toxicity in adult zebrafish

Mani, R. G. Geethu; Balasubramanian, Satheeswaran; Raghunath, Azhwar

doi:10.1007/s11356-019-06095-w

Cited by 25 publications

(6 citation statements)

References 84 publications

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“…Decreased phagocytosis of pathogenic bacteria Vibrio tubiashii was also observed in hemocytes which could render them more susceptible to bacterial infection. Inflammation and decreased AChE activity in muscle in fish chronically exposed to (1-3 mg/L) nCuO was observed (Mani et al, 2019). Decreased AChE was also observed in the mussel Mytilus galloprovincialis to 10 µg/L for 15 days (Gomes et al, 2011).…”

Section: Discussionmentioning

confidence: 89%

Comparative Toxicity of Copper Oxide Nanoparticles and Dissolved Copper to Freshwater Mussels

Auclair¹,

Turcotte²,

Gagnon³

et al. 2019

IJZI

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The commercial use of copper oxide nanoparticles (nCuO) has raised concerns about the toxic risk to filter feeders such as bivalves. The purpose of this study was to compare the toxicity of nCuO and dissolved Cu 2+ to the freshwater mussel Dreissena bugensis. Mussels were exposed to a range of concentrations of both forms of Cu (2, 10 and 50 µg/L) for 96 h at 15 C. After the exposure period, some mussels were kept aside to determine the air survival time as a measure of resistance to stress. The remaining mussels were processed for total and labile Cu determination in their tissues and the following effects: lipid peroxidation (LPO), DNA damage, arachidonate cyclooxygenase (COX), protein-ubiquitin levels (UB), acetylcholinesterase (AChE) and glutathione S-transferase (GST) activity. The data revealed that only exposure to Cu 2+ led to the accumulation of total Cu in tissues with a decrease in labile Cu 2+ levels suggesting that Cu was strongly bound to tissues. Exposure to nCuO led to specific effects on COX activity (inflammation) and UB levels (damaged protein turnover). It is concluded that although no significant changes in Cu levels in mussels were detected, exposure to nCuO produced different effects than Cu 2+ in freshwater mussels.

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Section: Discussionmentioning

confidence: 89%

Comparative Toxicity of Copper Oxide Nanoparticles and Dissolved Copper to Freshwater Mussels

Auclair¹,

Turcotte²,

Gagnon³

et al. 2019

IJZI

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“…Although there are no reports in the literature on the effect of embedded metals on creatine kinase activity in skeletal muscle, there are indications that environmental metal contamination can affect activity. For example, in a zebrafish model, chronic exposure to copper oxide nanoparticles elevated creatine kinase activity in skeletal muscle ( Mani et al, 2020 ); while in normal muscle, creatine kinase levels decreased as the animal aged ( Nuss et al, 2009 ). Creatine kinase activity in the gastrocnemius homogenate from tantalum-control rats decreased over time reaching a nadir at 6-months post-implantation.…”

Section: Discussionmentioning

confidence: 99%

Oxidative damage in metal fragment-embedded Sprague-Dawley rat gastrocnemius muscle

Kalinich

Vergara

Hoffman

2022

Current Research in Toxicology

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“…Recently, it has been evident that these could be used in the analysis of neurodegenerative diseases and muscle pathologies such as atrophy [35,36]. On the other hand, these models also highlight atrophic muscle injuries associated with chemicals such as alcohol or copper oxide nanoparticles [37,38]. However, the damage to muscle tissue in zebrafish and other fish species is different from that found in X. maculatus, being characterized by fibrillar and perimisial degeneration, inflammation, vacuolar degeneration, and atrophy [39].…”

Section: Discussionmentioning

confidence: 99%

Atrophy and Muscular Fibrosis of Unknown Etiology during the Raising of Xiphophorus maculattus on an Ornamental Fish Farm

Romano

Medeiros

Pedrosa

2020

AJRiZ

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During the last two decades, the implementation of histochemical, immunohistochemical, electron microscopy, and recently developed molecular techniques has greatly contributed to our knowledge of skeletal muscle, both normal and sick. This article reports the presence of muscular atrophy and fibrosis in Xiphophorus maculatus from an ornamental fish farm. We do not know the origin of this muscular pathology and the purpose of this work is to summarize some of the findings with optical microscopy and electron microscopy shared by all. Although we cannot establish the etiology of this atrophy, we will try to correlate the ultrastructural alterations with the muscular histopathology. Muscular atrophy is a pathology characterized by loss of normal muscle mass. It is caused by a decrease in the total number of muscle cells or by a substantial reduction in the substance of individual muscle cells. It is likely that the cases reported here represent a pathology involving causes concurrent with nutritional problems and disorders of muscle innervation. Therefore, future studies should investigate further about the potential of neurodegenerative disorders. Several experimental models can use muscular atrophy and are suitable for investigations of the underlying mechanisms of this pathology.

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Chronic exposure to copper oxide nanoparticles causes muscle toxicity in adult zebrafish

Cited by 25 publications

References 84 publications

Comparative Toxicity of Copper Oxide Nanoparticles and Dissolved Copper to Freshwater Mussels

Comparative Toxicity of Copper Oxide Nanoparticles and Dissolved Copper to Freshwater Mussels

Oxidative damage in metal fragment-embedded Sprague-Dawley rat gastrocnemius muscle

Atrophy and Muscular Fibrosis of Unknown Etiology during the Raising of Xiphophorus maculattus on an Ornamental Fish Farm

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