Chronic exposure to traffic-related air pollution reduces lipid mediators of linoleic acid and soluble epoxide hydrolase in serum of female rats

Liang, Nuanyi; Emami, Shiva; Patten, Kelley T; Valenzuela, Anthony; Wallis, Christopher; Wexler, Anthony S.; Bein, Keith J.; Lein, Pamela J.; Taha, Ameer Y.

doi:10.1016/j.etap.2022.103875

Cited by 4 publications

(2 citation statements)

References 72 publications

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“…Environmental tobacco smoke exposure in healthy children at risk for type 1 diabetes was associated with lipoxin A 4 [87], and short-term exposure to air particulate matter decreased leukotriene B 4 , 12- and 15-HETE, 12-HEPE and 17-HDoHE and increased 5,6-DiHETrE and prostaglandin E 2 [88]. In another study, exposure of rats to traffic-related air pollution compared to filtered air for 14 months reduced free and esterified levels of 9-HODE, 11,12-DiHETrE and 16,17-dihydroxy-docosapentaenoic acid in serum [89]. Urinary phenols (derived from chemicals prevalent in many personal care products, packaged foods, and plastics) are associated with 50% higher levels of 12-HETE, and urine phthalate (found in cosmetics, fragrances, shampoo and food packaging material) and organophosphate ester metabolites (found in flame retardants and plasticizers used in many household and personal care products) are associated with higher concentrations of LNA oxylipins produced via CYP, such as dihydroxy-octadecenoic acids [90].…”

Section: Biological Variation Of Oxylipins – Sex Genetics and Environ...mentioning

confidence: 92%

Factors affecting variability in free oxylipins in mammalian tissues

Aukema

Ravandi

2022

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of the reviewAlong with the growing interest in oxylipins is an increasing awareness of multiple sources of variability in oxylipin data. This review summarizes recent findings that highlight the experimental and biological sources of variation in free oxylipins.Recent findingsExperimental factors that affect oxylipin variability include different methods of euthanasia, postmortem changes, cell culture reagents, tissue processing conditions and timing, storage losses, freeze-thaw cycles, sample preparation techniques, ion suppression, matrix effects, use and availability of oxylipin standards, and postanalysis procedures. Biological factors include dietary lipids, fasting, supplemental selenium, vitamin A deficiency, dietary antioxidants and the microbiome. Overt, but also more subtle differences in health affect oxylipin levels, including during resolution of inflammation and long-term recovery from disease. Sex, genetic variation, exposure to air pollution and chemicals found in food packaging and household and personal care products, as well as many pharmaceuticals used to treat health conditions also affect oxylipin levels.SummaryExperimental sources of oxylipin variability can be minimized with proper analytical procedures and protocol standardization. Fully characterizing study parameters will help delineate biological factors of variability, which are rich sources of information that can be used to probe oxylipin mechanisms of action and to investigate their roles in health.

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Section: Biological Variation Of Oxylipins – Sex Genetics and Environ...mentioning

confidence: 92%

Factors affecting variability in free oxylipins in mammalian tissues

Aukema

Ravandi

2022

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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“…[14][15][16]33 In vitro, exposure to PM induced the production of eicosanoids in epithelial cells, 34 alveolar macrophages, 35 and endothelial cells. 36 Exposure to PM altered the levels of eicosanoids in mouse blood, 37 lung, 38 and small intestine. 39 Consistent with those in vivo and in vitro studies, a randomized crossover trial in healthy adults reported that short-term exposure to PM 2.5 disturbed ARA metabolism.…”

Section: Prohypertensive Changes Associated With Pm Exposurementioning

confidence: 99%

Particulate Air Pollution and Blood Pressure: Signaling by the Arachidonate Metabolism

Wang,

Han,

Chen

et al. 2023

Hypertension

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BACKGROUND: Short-term exposure to ambient particulate matter (PM) can raise blood pressure, but the underlying mechanisms are unclear. We explored whether arachidonate metabolites serve as biological intermediates in PM-associated prohypertensive changes. METHODS: This panel study recruited 110 adults aged 50 to 65 years living in Beijing, China. The participants’ blood pressure, arterial stiffness, and cardiac and endothelial function were measured up to 7 times. The serum concentrations of arachidonate metabolites were quantified by targeted lipidomics. Ambient concentrations of fine PM (PM 2.5 ), black carbon, and accumulation mode particles were continuously monitored at a station and their associations with the health indicators were evaluated. RESULTS: Interquartile range increases in 25 to 96-hour-lag exposure to PM 2.5 , black carbon, and accumulation mode particles were associated with significant increases in systolic blood pressure (brachial: 0.8–3.2 mm Hg; central: 0.7–2.8 mm Hg) and diastolic blood pressure (brachial, 0.5–1.5 mm Hg; central, 0.5–1.6 mm Hg). At least 1 pollutant was associated with increases in augmentation pressure and heart rate and decreases in reactive hyperemia index and ejection time. The serum concentrations of arachidonate were significantly increased by 3.3% to 14.6% in association with PM exposure, which mediated 9% of the PM-associated increases in blood pressure. The levels of eicosanoids from the cytochrome P450, cyclooxygenase, and lipoxygenase pathways changed with PM exposure, and those from the cytochrome pathway significantly mediated the association between PM exposure and blood pressure. Conclusions: Short-term exposure to particulate air pollution was associated with a prohypertensive change in adults, which was in part mediated by alteration of arachidonate metabolism.

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Neuroinflammation is dependent on sex and ovarian hormone presence following acute woodsmoke exposure

Wardhani,

Yazzie,

Edeh

et al. 2024

Sci Rep

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Woodsmoke (WS) exposure is associated with significant health-related sequelae. Different populations can potentially exhibit varying susceptibility, based on endocrine phenotypes, to WS and investigating neurological impacts following inhaled WS is a growing area of research. In this study, a whole-body inhalation chamber was used to expose both male and female C57BL/6 mice (n = 8 per group) to either control filtered air (FA) or acute WS (0.861 ± 0.210 mg/m3) for 4 h/d for 2 days. Neuroinflammatory and lipid-based biological markers were then assessed. In a second set of studies, female mice were divided into two groups: one group was ovariectomized (OVX) to simulate an ovarian hormone-deficient state (surgical menopause), and the other underwent Sham surgery as controls, to mechanistically assess the impact of ovarian hormone presence on neuroinflammation following FA and acute WS exposure to simulate an acute wildfire episode. There was a statistically significant impact of sex (P ≤ 0.05) and statistically significant interactions between sex and treatment in IL-1β, CXCL-1, TGF-β, and IL-6 brain relative gene expression. Hippocampal and cortex genes also exhibited significant changes in acute WS-exposed Sham and OVX mice, particularly in TGF-β (hippocampus) and CCL-2 and CXCL-1 (cortex). Cortex GFAP optical density (OD) showed a notable elevation in male mice exposed to acute WS, compared to the control FA. Sham and OVX females demonstrated differential GFAP expression, depending on brain region. Overall, targeted lipidomics in phosphatidylcholine (PC) and phosphatidylethanolamine (PE) serum and brain lipids demonstrated more significant changes between control FA and acute WS exposure in female mice, compared to males. In summary, male and female mice show distinct neuroinflammatory markers in response to acute WS exposure. Furthermore, ovarian hormone deficiency may impact the neuroinflammatory response following an acute WS event.

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Chronic exposure to traffic-related air pollution reduces lipid mediators of linoleic acid and soluble epoxide hydrolase in serum of female rats

Cited by 4 publications

References 72 publications

Factors affecting variability in free oxylipins in mammalian tissues

Factors affecting variability in free oxylipins in mammalian tissues

Particulate Air Pollution and Blood Pressure: Signaling by the Arachidonate Metabolism

Neuroinflammation is dependent on sex and ovarian hormone presence following acute woodsmoke exposure

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