Chronic fatigue syndrome – an update

Rimbaut, Steven; Gutte, Céline Van; Brabander, Lina Van; Bossche, Luc Vanden

doi:10.1080/17843286.2016.1196862

Cited by 20 publications

(18 citation statements)

References 80 publications

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“…Our results on case characteristics are in line with several other studies on specific FSS It is a consistent finding that the female sex dominates in both IBS [10][11][12][13]49 , FM 5,14,16,50 , CFS 17,19,51 , WAD 52 , and MCS 22,23 . However, one study did not find any pronounced predominance of the female sex in FM 53 .…”

Section: Discussionsupporting

confidence: 92%

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Irritable bowel, chronic widespread pain, chronic fatigue and related syndromes are prevalent and highly overlapping in the general population: DanFunD

Petersen

Schröder

Jørgensen

et al. 2020

Sci Rep

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prevalence of functional somatic syndromes (fSS) in the general population varies with observed overlap between syndromes. However, studies including a range of fSS are sparse. We investigated prevalence and characteristics of various fSS and the unifying diagnostic construct bodily distress syndrome (BDS), and identified mutual overlap of the FSS and their overlap with BDS. We included a stratified subsample of 1590 adults from a randomly selected Danish general population sample (n = 7493). Telephonic diagnostic interviews performed by three trained physicians were used to identify individuals with FSS and BDS. Prevalence of overall FSS was 9.3%; 3.8% for irritable bowel, 2.2% for chronic widespread pain, 6.1% for chronic fatigue, 1.5% for whiplash associated disorders, and 0.9% for multiple chemical sensitivity. Prevalence of BDS was 10.7% where 2.0% had the multi-organ type. fSS were highly overlapping with low likelihood of having a "pure" type. Diagnostic agreement of FSS and BDS was 92.0%. Multi-syndromatic FSS and multi-organ BDS were associated with female sex, poor health, physical limitations, and comorbidity. fSS are highly prevalent and overlapping, and multi-syndromatic cases are most affected. BDS captured the majority of FSS and may improve clinical management, making the distinction between multi-and mono-syndromatic patients easier. Functional somatic syndromes (FSS), such as irritable bowel syndrome (IBS), fibromyalgia/chronic widespread pain (FM/CWP), chronic fatigue syndrome (CFS), whiplash associated disorders (WAD), and multiple chemical sensitivity (MCS), are prevalent in various medical settings and cause great impairment in patients and high health care costs for society. A variety of other terms are used in the literature for these syndromes, central sensitization syndromes 1 and medically unexplained symptoms 2 among others, which underlines the very different conceptualization of these health conditions in current medicine. However, regardless the clinician's a-priori conceptualisation, the present lack of objective clinical signs or reproducible paraclinical findings constitutes a diagnostic challenge as the diagnoses in clinical practise rely on subjective symptom reports, exclusion of relevant differential diagnoses, and the medical history 3-9. Reviews on IBS, FM, and CFS have shown varying prevalence in general populations: 1-45% for IBS 6,10-13 , 0.5-9% for FM 5,14-16 , and 0.1-2.8% for CFS 17-20. One population-based study has found a prevalence of WAD of 1.4-2.9% 21. For MCS, reviews of population-based prevalence also vary tremendously: One review presented prevalence of physician-diagnosed MCS of 0.5% reviews while another have reported a prevalence of MCS of between 1 and 15% 22,23. The considerable variation in prevalence may be attributed to the different diagnostic criteria used for each FSS. Furthermore, a substantial overlap of symptoms between various FSS diagnoses has been shown, indicating

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Section: Discussionsupporting

confidence: 92%

“…Unemployment and the inability to maintain a job have also previously shown to be associated with both IBS 10,11 , FM 16,50 , and CFS 17,51 .…”

Section: Discussionmentioning

confidence: 95%

Irritable bowel, chronic widespread pain, chronic fatigue and related syndromes are prevalent and highly overlapping in the general population: DanFunD

Petersen

Schröder

Jørgensen

et al. 2020

Sci Rep

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“…In this report, of the 54 ME/CFS patients, 50% received financial disability compensation. Low employment rates are believed to contribute to the economic burden imposed by ME/CFS [23]. Using archival data from USA, Jason and colleagues reported that the annual direct cost per ME/CFS patient was estimated between US$2,342 and US$8,675 [24].…”

Section: Discussionmentioning

confidence: 99%

Health-related quality of life in patients with myalgic encephalomyelitis/chronic fatigue syndrome: an Australian cross-sectional study

et al. 2020

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Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious and debilitating disorder associated with significant disruptions in daily life including. This study aimed to examine the impact of sociodemographic and patient symptom characteristics on health-related quality of life (HRQoL) of Australians with ME/CFS. Methods Self-reported data collected from 480 individuals diagnosed with ME/CFS were obtained between August 2014 and August 2018. This cross-sectional survey analysed sociodemographic, symptom characteristics and HRQoL according to the 36-Item Health Survey (SF-36). Multivariate linear regression models were used to determine ME/CFS symptoms associated with eight domains of HRQoL. Results Reported HRQoL was significantly impaired in ME/CFS patients across all domains compared with the general population. Scores were the lowest for physical role (4.11 ± 15.07) and energy/fatigue (13.54 ± 13.94). Associations with females, higher body mass index (BMI), employment status, cognitive difficulties, sensory disturbances and cardiovascular symptoms were observed in the physical functioning domain. Impaired pain domain scores were associated with high BMI, annual visits to their general practitioner, flu-like symptoms and fluctuations in body temperature. Reduced well-being scores were associated with smoking status, psychiatric comorbidity, cognitive difficulties, sleep disturbances and gastrointestinal difficulties. Conclusion This study provides evidence that ME/CFS has a profound and negative impact on HRQoL in an Australian cohort.

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“…There is no consensus on how best to treat either ES [9] or CFS [10]. In both conditions, cognitive behavioural therapy (CBT) and multidisciplinary rehabilitation are the usual treatment approaches [9,[11][12][13][14]. In a randomized control trial for ES comparing Qigong alone (gentle movements, body awareness, balance and coordination, breathing, relaxation and mindfulness) or in combination with CBT, 75% of patients in both treatment arms had returned to work at the three-year follow-up [15].…”

Section: Precipitating Factormentioning

confidence: 99%

Similarities and differences between health-related quality of life in patients with exhaustion syndrome and chronic fatigue syndrome

Maroti

Bilevičiūtė-Ljungar

2018

Fatigue: Biomedicine, Health & Behavior

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Background: Patients with exhaustion syndrome (ES), the clinical equivalent of long-lasting burnout, and chronic fatigue syndrome (CFS) report overlapping symptoms such as exhaustion, fatigue, cognitive deficits and intolerance to stressors. Additionally, patients with CFS experience somatic symptoms, including bodily pain, immune symptoms, and post-exertional malaise. Clinically, patients with CFS often have reduced functioning as compared to ES, but studies comparing quality of life have not been reported. Purpose: To compare quality of life between patients with ES (n = 31), CFS (n = 38) and healthy controls (HC) (n = 30) by using the Short Form 36 questionnaire (SF-36) and the Hospital Anxiety and Depression Scale (HADS). Results: Patients with CFS scored lower in all quality of life dimensions on the SF-36 as compared to the ES and HC groups, except for the role emotional and mental health subscales. Patients with ES scored lower on the subscales of physical role, vitality, social functioning and role emotional as compared to HC. Physical Component Summary scores were lower in CFS, while the Mental Component Summary scores were lower in ES as compared to CFS and HC. Higher scores for depression symptoms on the HADS and group membership explained the major part of variance. Conclusion: Findings indicated both similarities and differences on the SF-36 in patients with ES as compared to CFS. Both groups showed a substantial reduction in quality of life as compared to controls. Perhaps surprisingly, mental health was less affected in patients with CFS. Emotional status appears to be important in affecting health-related quality of life in both illnesses.

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Chronic fatigue syndrome – an update

Cited by 20 publications

References 80 publications

Irritable bowel, chronic widespread pain, chronic fatigue and related syndromes are prevalent and highly overlapping in the general population: DanFunD

Irritable bowel, chronic widespread pain, chronic fatigue and related syndromes are prevalent and highly overlapping in the general population: DanFunD

Health-related quality of life in patients with myalgic encephalomyelitis/chronic fatigue syndrome: an Australian cross-sectional study

Similarities and differences between health-related quality of life in patients with exhaustion syndrome and chronic fatigue syndrome

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