Chronic fatigue syndrome and fibromyalgia in diagnosed sleep disorders: a further test of the ‘unitary’ hypothesis

Pejovic, Slobodanka; Natelson, Benjamin H.; Basta, Maria; Fernández-Mendoza, Julio; Mahr, Fauzia; Vgontzas, Alexandros N.

doi:10.1186/s12883-015-0308-2

Cited by 19 publications

(10 citation statements)

References 34 publications

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“…The change was moderately related to pain reduction, which is in agreement with observational studies in patients showing that chronic pain conditions are associated with perceptions of fatigue and exertion. [29,30] In addition, the inverse relationship between the changes in pain and vitality in the present study further indicates that they share common underlying biopsychosocial mechanisms.…”

Section: Discussionsupporting

confidence: 63%

Psychosocial effects of workplace physical exercise among workers with chronic pain

2017

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While workplace physical exercise can help manage musculoskeletal disorders, less is known about psychosocial effects of such interventions. This aim of this study was to investigate the effect of workplace physical exercise on psychosocial factors among workers with chronic musculoskeletal pain.The trial design was a 2-armed parallel-group randomized controlled trial with allocation concealment. A total of 66 slaughterhouse workers (51 men and 15 women, mean age 45 years [standard deviation (SD) 10]) with upper limb chronic musculoskeletal pain were randomly allocated to group-based strength training (physical exercise group) or individual ergonomic training and education (reference group) for 10 weeks. Social climate was assessed with the General Nordic Questionnaire for Psychological and Social Factors at Work, and vitality and mental health were assessed with the 36-item Short Form Health Survey. All scales were converted to 0 to 100 (higher scores are better). Between-group differences from baseline to follow-up were determined using linear mixed models adjusted for workplace, age, gender, and baseline values of the outcome.Mean baseline scores of social climate, mental health, and vitality were 52.2 (SD 14.9), 79.5 (SD 13.7), and 53.9 (SD 19.7), respectively. Complete baseline and follow-up data were obtained from 30 and 31 from the physical exercise and reference groups, respectively. The between-group differences from baseline to follow-up between physical exercise and reference were 7.6 (95% CI 0.3 to 14.9), −2.3 (95% CI -10.3 to 5.8), and 10.1 (95% CI 0.6 to 19.5) for social climate, mental health, and vitality, respectively. For social climate and vitality, this corresponded to moderate effect sizes (Cohen d = 0.51 for both) in favor of physical exercise. There were no reported adverse events.In conclusion, workplace physical exercise performed together with colleagues improves social climate and vitality among workers with chronic musculoskeletal pain. Mental health remained unchanged.

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Section: Discussionsupporting

confidence: 63%

Psychosocial effects of workplace physical exercise among workers with chronic pain

2017

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“…7 Finally, our group has identified a series of patients diagnosed with obstructive sleep apnea based on data recorded during overnight polysomnography. 18 Fourteen percent of these patients had CFS only, 4% fulfilled case criteria for the diagnosis of CFS and fibromyalgia; in contrast, none of these patients had fibromyalgia only. These findings indicate discordance in rates of CFS and fibromyalgia; compared with substantially higher rates for CFS (compare 14% to 0.3% in community samples), rates of fibromyalgia only were not different from those found in community samples (approximately 4% in both).…”

mentioning

confidence: 89%

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: Definitions, Similarities, and Differences

Natelson

2019

Clinical Therapeutics

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This commentary presents a simplified way of making the diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) using the 1994 Centers for Disease Control and Prevention case definition. The format used can easily be modified for other case definitions. The commentary then discusses whether ME/CFS is the same or a different illness from fibromyalgia. Because overlap exists between the 2 syndromes, some investigators have posited that they are variants of the same illness. I have viewed this as an empirically testable hypothesis and have summoned considerable amounts of data that suggest that the 2 illnesses differ. Were differences to exist, that would suggest different pathophysiologic processes for each, leading to different treatments. (Clin Ther. 2019;41:612e618)

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“…Pain can alter sleep patterns, increasing the latency of sleep onset and inducing frequent arousals (Fishbain, Cole, Lewis, & Gao, 2010). Patients with CFS/ME may also present a substantial psychiatric component and fibromyalgia (FM) as co-morbid illnesses (Pejovic et al, 2015), which can alter the sleep pattern. Moreover, several of the treatments prescribed, such as analgesics/anti-inflammatory (i.e.…”

mentioning

confidence: 99%

Poor self‐reported sleep quality and health‐related quality of life in patients with chronic fatigue syndrome/myalgic encephalomyelitis

Castro-Marrero

Zaragozá

González-García

et al. 2018

Journal of Sleep Research

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Non-restorative sleep is a hallmark symptom of chronic fatigue syndrome/myalgic encephalomyelitis. However, little is known about self-reported sleep disturbances in these subjects. This study aimed to assess the self-reported sleep quality and its impact on quality of life in a Spanish community-based chronic fatigue syndrome/myalgic encephalomyelitis cohort. A prospective cross-sectional cohort study was conducted in 1,455 Spanish chronic fatigue syndrome/myalgic encephalomyelitis patients. Sleep quality, fatigue, pain, functional capacity impairment, psychopathological status, anxiety/depression and health-related quality of life were assessed using validated subjective measures. The frequencies of muscular, cognitive, neurological, autonomic and immunological symptom clusters were above 80%. High scores were recorded for pain, fatigue, psychopathological status, anxiety/depression, and low scores for functional capacity and quality of life, all of which correlated significantly (all p < 0.01) with quality of sleep as measured by the Pittsburgh Sleep Quality Index. Multivariate regression analysis showed that after adjusting for age and gender, the pain intensity (odds ratio, 1.11; p <0.05), psychopathological status (odds ratio, 1.85; p < 0.001), fibromyalgia (odds ratio, 1.39; p < 0.05), severe autonomic dysfunction (odds ratio, 1.72; p < 0.05), poor functional capacity (odds ratio, 0.98; p < 0.05) and quality of life (odds ratio, 0.96; both p < 0.001) were significantly associated with poor sleep quality. These findings suggest that this large chronic fatigue syndrome/myalgic encephalomyelitis sample presents poor sleep quality, as assessed by the Pittsburgh Sleep Quality Index, and that this poor sleep quality is associated with many aspects of quality of life.

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Chronic fatigue syndrome and fibromyalgia in diagnosed sleep disorders: a further test of the ‘unitary’ hypothesis

Cited by 19 publications

References 34 publications

Psychosocial effects of workplace physical exercise among workers with chronic pain

Psychosocial effects of workplace physical exercise among workers with chronic pain

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: Definitions, Similarities, and Differences

Poor self‐reported sleep quality and health‐related quality of life in patients with chronic fatigue syndrome/myalgic encephalomyelitis

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