Chronic Gastritis Mimicking Malignancy on 68Ga-FAPI-04 PET/CT

Abstract

We present 2 patients mimicking malignancy with intense gastric 68Ga-FAPI-04 uptake on PET/CT. Both patients showed low to moderate 18F-FDG uptake. Histopathology revealed chronic active gastritis. Chronic gastritis may resemble gastric malignancies by showing false-positive 68Ga-FAPI-04 uptake.

18F-FAPI-04 PET/CT in a Case of Primary Gastric Plasmacytoma

“…[13][14][15][16] FAPI PET/CT may be not superior to FDG PET/CT in detecting osseous or extraosseous myeloma lesions. 13 This case indicates gastric plasmacytoma should be included in the differential diagnosis of malignant and benign etiologies of stomach-related elevated FAPI activity including adenocarcinoma, 17 gastrointestinal stromal tumor, 18 Kaposi sarcoma, 19 lymphoma, 20 chronic gastritis, 21 and fibrous hyperplasia. 22…”