Chronic Graft‐versus‐Host Disease with Follicular Involvement

Abstract

The clinical and histopathological findings in a 25-year-old Japanese male patient who suffered from chronic graft-versus-host-disease (GVHD) with follicular involvement are described. The patient had been diagnosed as aplastic anemia and underwent an allogeneic bone marrow transplant (BMT). In the eighth month thereafter, pruritic follicular red papules developed over his trunk and extremities. A biopsy specimen revealed histological exocytosis of lymphocytes into the hair follicles and basal-cell vacuolization of the follicular epithelium. Analysis of T-lymphocyte subpopulations in the dermis revealed a predominance of CD4 positive cells. To our knowledge, several cases of acute follicular GVHD have been reported; however, the occurrence of chronic GVHD with follicular involvement (chronic follicular GVHD) has not been clearly documented.

A Follicular Lichenoid Eruption as Manifestation of Chronic Graft-vs-Host Disease

“…In all these patients the eruption was progressive and persistent, and the patients died shortly after the diagnosis was made (1^3). In contrast, in the 3 reported cases of chronic follicular GVHD, the follicular eruption developed late in the clinical course and was associated with an excellent clinical outcome (4,5).…”

Familial cicatricial alopecia: Report of familial frontal fibrosing alopecia and fibrosing alopecia in a pattern distribution

“…Miyazaki et al . [ 22 ] reported the first case of GvHD with follicular involvement. Moreover, GvHD may present on the scalp as FAPD (personal observation), as originally reported by Basilio et al .…”

Follicular graft-versus-host disease: A rare manifestation in a patient with the overlap subtype of chronic graft-versus-host disease

“…[1] However, lichenoid follicular eruption as a major clinical manifestation of chronic cutaneous GVHD is rare; to our best knowledge, only seven cases have been reported to date [Table 1]. [23456] Here, we describe a patient with multiple myeloma who had a generalized follicular eruption that appeared on day 53 following HSCT.…”