Chronic granulomatous cheilitis and its relationship to Crohn's disease

Orofacial granulomatosis: presentation, pathology and management of 13 cases

“…The association of sarcoidosis and Crohn's disease is tenuous as few patients manifested both diseases simultaneously (29, 59). Reports of patients with recurrent, non‐inflammatory swelling of the lip (Miescher's cheilitis granulomatosa), who subsequently developed Crohn's disease, are well documented (52, 53, 60–62). HLA phenotyping has not been helpful in demonstrating a firm genetic link.…”

Granulomatous Cheilitis and Crohn's Disease in a 3‐Year‐Old Boy

“…Published articles describing the occurrence or GC and CD recommend systemic investigation once a patient presents with GC ( 4–10). Since these case reports are sparse and the disorders cannot be distinguished histologically, the causal relationship is questioned by several authors ( 11–14). Worsaae et al.…”

“…Published articles describing the occurrence or GC and CD recommend systemic investigation once a patient presents with GC (4-10). Since these case reports are sparse and the disorders cannot be distinguished histologically, the causal relationship is questioned by several authors (11)(12)(13)(14). Worsaae et al (12) did not find CD in any of 16 patients with complete MRS or GC and therefore considered a systemic investigation of GC patients to be unnecessary.…”

“…The association of GC and CD is rarely described in the literature ( 4–10). Whether GC is a manifestation of CD or a distinct pathologic entity is still controversial ( 11–14). We describe a 3‐year‐old boy who was admitted to our institute with GC.…”

Lip impressions: a new method for monitoring morphological changes in orofacial granulomatosis

“…This technique is capable of imaging soft tissues without using ionizing radiation but has many disadvantages, including the high cost and the contraindication for certain patients. In numerous case reports (Krutchkoff and James, 1978; Brook et al , 1983; Hernandez et al , 1986; Williams and Greenberg, 1991; Kano et al , 1992; Mignogna et al , 2001) and series of patients (Rhodes and Stirling, 1965; Worsaae et al , 1982; Podmore and Burrows, 1986; Field and Tyldesley, 1989; Pachor et al , 1989; Zimmer et al , 1992; Kolokotronis et al , 1997; Girlich et al , 2002; Mignogna et al , 2003; Sciubba and Said‐Al‐Naief, 2003) the swelling of the lips has been followed up and assessed using clinical photographs. The use of photographs offers the advantage of keeping a permanent record to monitor the progress of the disease but is essentially at best only semi‐quantative and does not allow subtle changes to be detected.…”