Chronic hepatitis B and D: prognosis according to Child-Pugh score

Oliveira, Marcelo Siqueira de; Silva, Romeu Paulo Martins; Valle, Suiane da Costa Negreiros do; Figueiredo, Elisabeth Níglio de; Fram, Dayana Souza

doi:10.1590/0034-7167-2016-0205

Cited by 7 publications

(4 citation statements)

References 21 publications

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“…However, the estimate of superinfected patients may vary according to the community or applied methodological design. In a study conducted in another health unit in the same region, a percentage of 57% of patients coinfected or superinfected with HDV was observed (22) .…”

Section: Discussionmentioning

confidence: 97%

Hepatitis B and Delta: clinical aspects of patients in the Brazilian Western Amazonia

et al. 2019

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Objective: to analyze clinical, serological, biochemical and hematological aspects in patients infected with the hepatitis B (HBV) and Delta (HDV) viruses. Method: cross-sectional, descriptive and retrospective study, performed with patients chronically infected with HBV and superinfected with HDV. Results: among the 112 patients selected, 74% were monoinfected with HBV (Group HBV) and 26% were superinfected with HDV (Group HBV+HDV). There was no difference in gender distribution. The average age was 36 years with standard deviation of ±12 years. The symptoms and signs presented a higher proportion in Group HBV+HDV (p=0.001). In both groups, most patients had non-reactive AgHBe. The records of biochemical and hematologic changes showed highest proportion in Group VHB+VHD Group (p<0.05). Conclusion: the study found that patients were in clinical stages of the disease different from those in the initial examination for monitoring their chronic condition. The clinical profile suggests greater severity of liver disease among the patients superinfected with HDV.

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Section: Discussionmentioning

confidence: 97%

Hepatitis B and Delta: clinical aspects of patients in the Brazilian Western Amazonia

et al. 2019

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“…In the population studied, there was a higher prevalence in males, with a higher proportion in the immunoactive chronic hepatitis B group. This observation is not yet fully elucidated, however, in the Western Amazon, there are reports of predominance in men, a pattern applicable to most endemic areas in the world [14,15]. Other clinical studies also report a prevalence of men classi ed as having advanced liver disease [16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Clinical profile and parameters of patients infected with HBV and co-infected with HDV in Western Amazon

Silva,

Roca,

Passos-Silva

et al. 2023

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Background Hepatitis Delta represents an even greater risk in the progression of advanced liver disease compared with HBV and is related to rapid progression to liver cirrhosis and HCC. The exact mechanism that determines the spontaneous clearance of delta virus or its progression to fibrosis and cirrhosis remains unknown. In this scenario, studies on the influence of virological, immunological and genetic aspects related to clinical evolution in chronic carriers of HBV and HDV are still scarce, especially in the Amazon region. Therefore, this study aimed to analyze the clinical profile of infected and co-infected individuals in the Western Amazon. Methods The study was carried out at the Specialized Outpatient Clinic for Viral Hepatitis belonging to the Centro de Pesquisa em Medicina Tropical de Rondônia/CEPEM. 100 individuals were included, stratified into two groups: 50 with hepatitis B virus and 50 co-infected with hepatitis Delta virus. Results The overall mean age was 48 ± 10.38 years. For the HBV-positive and HDV-positive groups, 66% (33/50) and 54% (27/50) were men and 56% (28/50) and 58% (29/50) were on antiviral treatment, respectively. Among the HBV immune-active carriers, there was a predominance of men, high levels of HBV-DNA, thrombocytopenia and high levels of ALT and AST. HDV carriers with detectable HDV-RNA demonstrated predominance of thrombocytopenia and high levels of ALT and AST. Comparative analysis between patients with HBV and co-infected with HDV shows significant differences in terms of age, HBV viral load levels, platelet levels and albumin levels. Conclusion Thrombocytopenia, hypoalbuminemia, hepatomegaly, splenomegaly and advanced fibrosis were more prevalent in individuals infected with HDV compared to those monoinfected with HBV and may be important markers in differentiating the different infections. Patients with detectable HDV RNA also showed significant changes in biomarkers compared to undetectable patients, suggesting a worse prognostic effect in this group.

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“…Imaging evaluation was performed for all participants by abdominal ultrasound and the stage of liver fibrosis was assessed by transient elastography (Fibroscan) for all patients. Child-Turcotte-Pugh score was calculated for cirrhotic patients to assess the liver disease severity [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

Toll- like receptor 2 polymorphism and IL-6 profile in relation to disease progression in chronic HBV infection: a case control study in Egyptian patients

et al. 2022

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Chronic hepatitis B (CHB) has a wide range of outcomes depending on host immune responses mainly Toll-like receptors (TLRs) signaling and released cytokines. Toll-like receptor 2 (TLR2) single nucleotide polymorphisms (SNPs) and interleukin 6 (IL-6) may influence the course of CHB. We aimed to elucidate the relation between TLR-2 polymorphism, IL-6 profile, and CHB progression. We analyzed TLR-2 polymorphism (SNP; rs3804099) in 185 CHB patients and 60 controls using TaqMan allelic discrimination assay. Serum IL-6 levels were assessed by ELISA. IL-6 levels were considerably higher in active CHB and cirrhotic patients compared with inactive carriers and controls (P < 0.001). IL-6 showed positive correlation with ALT and advanced fibrosis in active CHB patients (r = 0.31, P = 0.02). A significant positive correlation was noticed between IL-6 and HBV DNA PCR in all CHB groups. TT genotype of rs3804099/TLR-2 was significantly more prevalent in inactive carriers compared to active hepatitis patients (P = 0.04, OR = 0.39 and 95% CI: 0.16–0.95). Both heterozygous CT and mutant TT genotypes were significantly more frequent among inactive carriers compared to cirrhotic patients (P = 0.01, OR = 0.33, 95% CI: 0.13–0.81 and P = 0.009, OR = 0.32, 95% CI: 0.13–0.77). TT genotype was significantly related to lower IL-6 levels in active hepatitis and cirrhotic groups (P = 0.005 and P = 0.001, respectively) showing that TLR mutations would be associated with milder hepatitis activity and lower possibility for disease progression. There may be a positive association between TLR2 rs3804099 polymorphism and hepatitis B activity. IL-6 is a good indicator of CHB disease progression.

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Chronic hepatitis B and D: prognosis according to Child-Pugh score

Cited by 7 publications

References 21 publications

Hepatitis B and Delta: clinical aspects of patients in the Brazilian Western Amazonia

Hepatitis B and Delta: clinical aspects of patients in the Brazilian Western Amazonia

Clinical profile and parameters of patients infected with HBV and co-infected with HDV in Western Amazon

Toll- like receptor 2 polymorphism and IL-6 profile in relation to disease progression in chronic HBV infection: a case control study in Egyptian patients

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