Chronic hepatitis B infection and the risk of gestational diabetes: a cross‐sectional study

Giles, Michelle; Davey, Mary‐Ann; Wallace, Euan M.

doi:10.1111/1471-0528.16217

Cited by 18 publications

(16 citation statements)

References 29 publications

(52 reference statements)

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“…Similarly, two different studies investigating the effect of HBV infection during pregnancy suggested that HBV infection represents a significant general risk for the development of GDM 59 . Contrasting results can be seen in another meta‐analysis by Kong et al.…”

Section: Discussionmentioning

confidence: 95%

The effects of hepatitis B virus infection on natural and IVF pregnancy: A meta‐analysis study

Farsimadan

Riahi

Muhammad

et al. 2021

Journal of Viral Hepatitis

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Background Hepatitis B virus (HBV) has been considered a significant cause of human reproductive failure in different studies; however, there is a considerable disagreement on the true impacts of HBV on female reproduction. This study has evaluated the impact of HBV infection on pregnancy complications in natural pregnancy and also on pregnancy outcomes in women undergoing in vitro fertilization (IVF) treatment. Method We searched Embase, Web of Science, PubMed and Google Scholar databases to identify the potentially relevant studies. Summary odds ratio (OR) or standardized mean difference (SMD) with 95% confidence interval (CI) was applied to assess the relationship. Heterogeneity testing, sensitivity analysis and publication bias testing were also performed. Results A total of 42 studies concerning the effect of HBV infection on the natural and IVF pregnancy were included in this study. Our meta‐analysis results revealed that HBV infection had a positive correlation to gestational diabetes mellitus (GDM) [OR = 1.32 (1.17–1.48) (p < 0.01)] and preterm birth [OR = 1.26 (1.14–1.40) (p < 0.01)] in natural pregnancy; however, HBV infection was not significantly associated with decreased fertility rates among the patients who underwent IVF. Conclusion This study revealed a strong association of GDM and preterm birth with higher rates of HBV infection in pregnant women. Also, our results suggested that HBV infection in patients undergoing IVF may not negatively influence the pregnancy outcome. It may be rational to conclude that IVF might be rather a safe and effective method for HBV+ females who desire to have children.

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Section: Discussionmentioning

confidence: 95%

The effects of hepatitis B virus infection on natural and IVF pregnancy: A meta‐analysis study

Farsimadan

Riahi

Muhammad

et al. 2021

Journal of Viral Hepatitis

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“…Several studies have reported an increased risk of GDM in pregnant women who are HBsAg carrier. For example, Giles et al showed that HBV was associated with GDM with a risk ratio of 1.750 for GDM (95% CI 1.600-1.900) [31]. The highest incidence (37.10%) of GDM was observed in women with HBV and a body mass index of >40 Kg/m 2 .…”

Section: Discussionmentioning

confidence: 99%

Maternal hepatitis B surface antigen carrier status and pregnancy outcome: a retrospective cohort study

et al. 2022

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To investigate the effect of maternal hepatitis B surface antigen (HBsAg) carrier status during pregnancy on pregnancy outcomes in a population of patients in Hangzhou, China. A retrospective cohort study was conducted to analyse data from 20 753 pregnant women who delivered at Hangzhou Women's Hospital between January 2015 and March 2020. Of these, 18 693 were normal pregnant women (the non-exposed group) and 735 were HBsAg carriers (the exposed group). We then analysed by binary multivariate logistic regression to determine the association between maternal HBsAg-positive and adverse pregnancy outcomes. The prevalence of HBsAg carriers was 3.78% and the odds ratio (OR) for maternal age in the exposed group was 1.081. Pregnant women who are HBsAg-positive in Hangzhou, China, are at higher risk of a range of adverse pregnancy outcomes, including intrahepatic cholestasis of pregnancy (ICP) (adjusted OR (aOR) 3.169), low birth weight (aOR 2.337), thrombocytopenia (aOR 2.226), fallopian cysts (aOR 1.610), caesarean scar pregnancy (aOR 1.283), foetal distress (aOR 1.414). Therefore, the obstetricians should pay particular attention to ICP, low birth weight, thrombocytopenia, fallopian cysts, caesarean scar, foetal distress in HBsAg-positive pregnant women.

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“…HERC5 gene expression is regulated by a variety of stimuli, particularly inflammatory factors (e.g., interferon, lipopolysaccharide (LPS), tumor necrosis factor α (TNF α ), and interleukin 1 β (IL-1 β) ) [ 51 ]. Several previous studies have shown that the incidence of GDM in pregnant women with chronic hepatitis B virus (HBV) infection is higher than that in the general population [ 52 , 53 ]. HBV infection may have an impact on glucose homeostasis and IR [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

The Neuropeptide-Related HERC5/TAC1 Interactions May Be Associated with the Dysregulation of lncRNA GAS5 Expression in Gestational Diabetes Mellitus Exosomes

Tang

Zhang

et al. 2022

Disease Markers

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Objective. The goal of this work was to look at the expression and probable role of exosomal long noncoding RNA (lncRNA) GAS5 in gestational diabetes mellitus (GDM), as well as forecast the importance of its interaction with neuropeptides in the progression of the disease. Methods. We divided 44 pregnant women visiting the obstetric outpatient clinics at the Affiliated Hospital of Guilin Medical College from January 2021 to December 2021 into healthy and GDM groups. We measured the expression levels of the lncRNA GAS5 in peripheral blood using PCR and compared the expression levels between the 2 groups. The Gene Expression Omnibus (GEO) database and the R software were used to analyse the differences in the genes expressed in the amniotic fluid cells in the GDM and normal groups. catRAPID was used to identify potential target proteins for GAS5. Key neuropeptide-related proteins and potential target proteins of GAS5 were extracted, and protein interaction networks were mapped. AlphaFold 2 was used to predict the structure of the target protein. The ClusPro tool was used to predict protein-protein interactions. ZDOCK was used to further confirm the protein–nucleic acid docking. Results. The lncRNA GAS5 was downregulated in the peripheral blood of pregnant women with GDM compared with normal pregnant women. The subcellular localization sites of GAS5 were the nucleus, cytoplasm, and ribosome; in addition, GAS5 was present in exosomes. Intercellular interactions, including neuropeptide receptors, were increased in the amniotic fluid cells of patients with GDM. Venn diagram analysis yielded seven neuropeptide-related proteins and three GAS5 target proteins. Among them, HERC5/TAC1 interacted and GAS5 docked well with HERC5. Conclusion. The lncRNA GAS5 in the peripheral blood exosomes in patients with GDM may be a new target for the detection of GDM, and the interaction between GAS5 and HERC5/TAC1 may be involved in the pathogenesis of GDM.

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Chronic hepatitis B infection and the risk of gestational diabetes: a cross‐sectional study

Cited by 18 publications

References 29 publications

The effects of hepatitis B virus infection on natural and IVF pregnancy: A meta‐analysis study

The effects of hepatitis B virus infection on natural and IVF pregnancy: A meta‐analysis study

Maternal hepatitis B surface antigen carrier status and pregnancy outcome: a retrospective cohort study

The Neuropeptide-Related HERC5/TAC1 Interactions May Be Associated with the Dysregulation of lncRNA GAS5 Expression in Gestational Diabetes Mellitus Exosomes

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