Chronic Hepatitis C Infection as a Risk Factor for Renal Cell Carcinoma

González, Humberto C.; Lamerato, Lois; Rogers, Craig G.; Gordon, Stuart C.

doi:10.1007/s10620-015-3521-3

Cited by 26 publications

(39 citation statements)

References 22 publications

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“…In a cohort study of 67,000 HCV-tested people, hepatitis C infection was associated with an approximately 80% increased risk of RCC (adjusted hazard ratio 1.77, 95% CI 1.05-2.98) [10] . A recent case-control study of 140 patients with RCC and 100 patients with colon cancer (controls) suggested that HCV infection was a significant risk factor for RCC [12] . The association of HCV with RCC can be attributed to the HCV virus core protein and the NY-REN-54 protein [6] .…”

Section: Discussionmentioning

confidence: 99%

“…Gordon et al [10] suggested that the average age of HCV carriers with RCC was significantly lower than that of HCV-negative individuals with RCC. In addition, Gonzalez et al [12] reported that RCC patients with a positive HCV status were significantly younger than RCC patients without HCV infection. In our study, we also observed that patients with RCC who were positive for HBV or HCV were significantly younger than RCC patients without chronic hepatitis virus infection.…”

Section: Discussionmentioning

confidence: 99%

“…Multiple risk factors have been identified for renal cancer, including hypertension [6] , end-stage renal disease [7] , smoking [8] , and obesity [9] . In addition, several case reports and one large case series have found an association between renal cancer and hepatitis C virus (HCV) [10][11][12] . Gordon et al [10] found that patients with HCV had an approximately 1.8-fold increased risk of RCC.…”

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confidence: 99%

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Kidney Cancer Linked to Chronic Hepatitis in the Asia-Pacific: A Population-Based Analysis

Lin

Yeh

Lin³

et al. 2016

Am J Nephrol

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Background: The association of renal cancer with viral hepatitis infection remains unclear. Using an insurance data set, this population-based case-control study evaluated the association of renal cancer with chronic hepatitis virus infection in an endemic area of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. Methods: We enrolled 17,747 patients with renal cancer during the period from 2000 to 2011 from the National Health Insurance Research Database of Taiwan. The control group comprised 35,494 randomly selected people without renal cancer matched by age and gender to the patients in the study group. ORs were calculated to assess the association of chronic hepatitis virus infection with renal cancer by using logistic regression analysis. Results: Renal cancer was associated with HBV and HCV infection (OR 1.38, 95% CI 1.24-1.54; OR 1.24, 95% CI 1.07-1.44, respectively). An analysis stratified by gender and age revealed that young male HBV carriers had a higher risk of renal cancer compared with men without viral hepatitis (age <55 years: OR 1.94, 95% CI 1.57-2.39; 55≤ age <64 years: OR 1.40, 95% CI 1.05-1.86). Male HCV-infected patients aged <55 years (OR 1.90, 95% CI 1.11-3.26) and female HCV carriers aged between 55 and 64 years (OR 1.59, 95% CI 1.00-2.53) had a significantly higher risk of renal cancer compared with their counterparts. Conclusions: Renal cancer is significantly associated with chronic hepatitis infection, particularly in younger HBV-infected men.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Kidney Cancer Linked to Chronic Hepatitis in the Asia-Pacific: A Population-Based Analysis

Lin

Yeh

Lin³

et al. 2016

Am J Nephrol

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“…HCV infection was highly associated with development of RRC (OR= 24.2). 61 This finding is supported by the Kaiser Permanente retrospective registry as well. 56 …”

Section: Introductionmentioning

confidence: 61%

Extrahepatic Manifestations of Hepatitis C Infection: Navigating CHASM

Sherman

2015

Curr HIV/AIDS Rep

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Purpose of review This article describes the importance of extra-hepatic systemic manifestations of chronic hepatitis C virus (HCV) infection. Recent findings While most HCV literature focuses on liver injury and fibrosis progression, a spectrum of systemic disease processes, collectively called CHASM (C Hepatitis Associated Systemic Manifestations) are present in a high proportion of infected persons. These include thyroid disease (Hashimoto’s thyroiditis, Graves disease, thyroid cancer), cardiovascular disease (atherosclerosis, carotid artery disease, coronary artery disease), renal disease (MPGN, glomerulosclerosis), eye disease (Mooren’s ulcers, sicca syndrome), skin disease (PCT, vasculitis, lichen planus), and lymphomas (NHL, splenic T-cell), and diabetes. Summary Mechanistic understanding of how HCV leads to CHASM processes could lead to development of new interventions. The role of early HCV treatment and cure may result in preventive strategies for a variety of complex disease states.

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“…The statistical heterogeneity was high with an I 2 of 77%. The association between RCC and HCV was marginally insignificant after the sensitivity analysis including only studies with confounder adjustment[16,18-20,22] with a pooled RR of 1.50 (95%CI: 0.93-2.42, I 2 =64%), as shown in Figure 2.…”

Section: Resultsmentioning

confidence: 97%

Hepatitis C infection and renal cell carcinoma: A systematic review and meta-analysis

Wijarnpreecha

Nissaisorakarn

Sornprom

et al. 2016

WJGP

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AIMTo investigate the association between hepatitis C virus (HCV) infection and risk of renal cell carcinoma (RCC).METHODSA literature search was performed from inception until February 2016. Studies that reported relative risks, odd ratios, hazard ratios or standardized incidence ratio comparing the risk of RCC among HCV-infected participants vs those without HCV infection were included. Participants without HCV infection were used as comparators. Pooled odds ratios and 95%CI were calculated using a random-effect, generic inverse variance method.RESULTSSeven observational studies were with 196826 patients were included in the analysis to assess the risk of RCC in patients with HCV. A significantly increased risk of RCC among participants with HCV infection was found with a pooled RR of 1.86 (95%CI: 1.11-3.11). The association between RCC and HCV was marginally insignificant after a sensitivity analysis limited only to studies with adjusted analysis, with a pooled RR of 1.50 (95%CI: 0.93-2.42).CONCLUSIONOur study demonstrated a potential association between HCV infection and RCC. Further studies of RCC surveillance in patients with HCV are required.

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Chronic Hepatitis C Infection as a Risk Factor for Renal Cell Carcinoma

Abstract: Patients with chronic HCV are at heightened risk of RCC.

Cited by 26 publications

References 22 publications

Kidney Cancer Linked to Chronic Hepatitis in the Asia-Pacific: A Population-Based Analysis

Kidney Cancer Linked to Chronic Hepatitis in the Asia-Pacific: A Population-Based Analysis

Extrahepatic Manifestations of Hepatitis C Infection: Navigating CHASM

Hepatitis C infection and renal cell carcinoma: A systematic review and meta-analysis

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