Chronic hormone replacement therapy alters thermoregulatory and vasomotor function in postmenopausal women

Brooks, Ellen; Morgan, Amy L.; Pierzga, Jane M.; Wladkowski, S. L.; O’Gorman, John; Derr, Janice; Kenney, W. Larry

doi:10.1152/jappl.1997.83.2.477

Cited by 101 publications

(84 citation statements)

References 35 publications

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“…It is well documented (3,11,25) that hormone replacement therapy in postmenopausal women acutely affects temperature regulation and control of body fluids. However, the chronic effects of hormone replacement therapy on thermoregulation during exercise and environmental stresses are not known.…”

Section: Discussionmentioning

confidence: 99%

“…The material and methods for the original data are presented in greater detail elsewhere (3,20,26). The PSI was applied to three different databases contributed from the authors of previously published papers (3,20,26).…”

Section: Methodsmentioning

confidence: 99%

“…The PSI was applied to three different databases contributed from the authors of previously published papers (3,20,26). Protocol 1.…”

Section: Methodsmentioning

confidence: 99%

“…Twenty-five postmenopausal women, divided into three groups, participated in this study (3). Two groups of eight women each were on chronic hormone replacement therapy (Ն2 yr) that consisted of estrogen only (E) or estrogen plus progesterone (EϩP).…”

Section: Methodsmentioning

confidence: 99%

“…The effects of different hormone replacement therapies for middleaged women on the thermoregulatory system during rest and exercise in the heat have also been studied extensively during the last decade (3,4,8,25). Analysis of circulating estrogen and progesterone during heat stress showed that an increased progesterone-to-estrogen ratio during the luteal phase was associated with an elevated T c (5).…”

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confidence: 99%

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Aging and assessment of physiological strain during exercise-heat stress

Moran

Kenney

Pierzga

et al. 2002

American Journal of Physiology-Regulatory, Integrative and Comp

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. Aging and assessment of physiological strain during exercise-heat stress. Am J Physiol Regulatory Integrative Comp Physiol 282: R1063-R1069, 2002 10.1152/ajpregu.00364.2001.-The purpose of this study was to evaluate the physiological strain index (PSI) for different age groups during exercise-heat stress (EHS). PSI was applied to three different databases. First, from young and middle-age men (21 Ϯ 2 and 46 Ϯ 5 yr, respectively) matched (n ϭ 9 each, P Ͼ 0.05) for maximal aerobic power. Subjects were heat acclimated by daily treadmill walking for two 50-min bouts separated by 10-min rest for 10 days in a hot-dry environment [49°C, 20% relative humidity (RH)]. The second database involved a group (n ϭ 8) of young (YA) and a group (n ϭ 7) of older (OA) men (26 Ϯ 1 and 69 Ϯ 1 yr, respectively) who underwent 16 wk of aerobic training and two control groups (n ϭ 7 each) who were matched for age to YA and OA. These four groups performed EHS at 36°C, 40% RH on a cycle ergometer for 60 min at 60% maximal aerobic power before and after training. The third database was obtained from three groups of postmenopausal women and a group of 10 men. Two groups of women (n ϭ 8 each) were undergoing hormone replacement therapy, estrogen or estrogen plus progesterone, and the third group (n ϭ 9) received no hormone replacement. Subjects were over 50 yr and performed the same EHS: exercising at 36°C, 40% RH on a cycle ergometer for 60 min. PSI assessed the strain for all three databases and reported differences were significant at P Ͻ 0.05. This index rated the strain in rank order, whereas the postacclimation and posttraining groups were assessed as having less strain than the preacclimation and pretraining groups. Furthermore, middle-aged women on estrogen replacement therapy had less strain than estrogen ϩ progesterone and no hormone therapy. PSI evaluation was extended for men and women of different ages (50-70 yr) during acute EHS, heat acclimation, after aerobic training, and inclusive of women undergoing hormone replacement therapy. esophageal temperature; heart rate; predictive indexes; rectal temperature COLLECTIVELY, THE LITERATURE on heat tolerance for the general population suggests that middle-aged and older men and women are more exercise-heat intolerant, suffering more physiological strain during exposure to a hot environment than younger individuals (6, 27). Older men and women have been reported to have higher heart rates (HR), higher mean skin and core (T c ) temperatures, and lower sweat rates than younger men and women during exercise-heat stress (EHS). However, it is unclear from these studies whether the exercise-heat intolerance observed with aging was related to age per se or associated with other factors such as certain disease states, decreased physical activity, and/or lowered aerobic fitness (21).In 1965, Robinson et al. (22) were the first to imply that "habitually active" middle-aged men displayed the same acute exercise-heat tolerance and acclimated to heat at about the same rate and degree as when th...

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The PSI was applied to three different databases contributed from the authors of previously published papers (3,20,26). Protocol 1.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Aging and assessment of physiological strain during exercise-heat stress

Moran

Kenney

Pierzga

et al. 2002

American Journal of Physiology-Regulatory, Integrative and Comp

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Pre‐ and postnatal development studies of lasofoxifene, a selective estrogen receptor modulator (SERM), in Sprague–Dawley rats

Weisenburger

Hagler

Tassinari

2004

Birth Defects Research Pt B

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The maternal findings in this study were related to the pharmacologic activity of lasofoxifene. Inhibition of growth of the F1 offspring after perinatal exposure to lasofoxifene was observed, but there were no significant effects on the sensory, behavioral, or functional measures, including learning and memory. There were no effects on the F2 generation. The findings are consistent with those reported for at least one other SERM. The findings of this study do not suggest increased risk for the primary indication of use in postmenopausal women.

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Intraventricular cerebrospinal fluid temperature analysis using MR diffusion‐weighted imaging thermometry in Parkinson's disease patients, multiple system atrophy patients, and healthy subjects

et al. 2015

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PurposeWe examined the temperature of the intraventricular cerebrospinal fluid (Tv) in patients with Parkinson's disease (PD) and those with multiple system atrophy (MSA) in comparison with healthy subjects, and we examined normal changes in this temperature with aging.MethodsTv was estimated by magnetic resonance (MR) diffusion-weighted imaging (DWI) thermometry in 36 PD patients (19 males, 17 females), 34 MSA patients (17 males, 17 females), 64 age-matched controls (27 men, 37 women), and 114 all-age adult controls (47 men, 67 women; 28–89 years old). The volume of lateral ventricles was also estimated using FreeSurfer in all subjects. Tv and ventricular volume data were compared among the PD and MSA patients and age-matched controls. We also evaluated the relationship between Tv and age in the 114 all-age controls, controlling for ventricular volume. Men and women were analyzed separately.ResultsThe male PD and MSA patients had significantly higher Tv values compared to the male controls, with no significant difference in ventricular volume among them. There was no significant difference in Tv between the female patients and controls. In the all-age male controls, there was a significant negative correlation between Tv and age controlling for ventricular volume, and this was not observed in the women.ConclusionDWI thermometry is a useful and easy method for demonstrating an altered intracranial environment in male patients and healthy controls, but not in females. DWI thermometry can thus be used to help to explore the pathophysiology of Parkinsonian syndromes and to differentiate individuals affected by neurodegenerative disease with autonomic dysfunction from those without it.

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Chronic hormone replacement therapy alters thermoregulatory and vasomotor function in postmenopausal women

Cited by 101 publications

References 35 publications

Aging and assessment of physiological strain during exercise-heat stress

Aging and assessment of physiological strain during exercise-heat stress

Pre‐ and postnatal development studies of lasofoxifene, a selective estrogen receptor modulator (SERM), in Sprague–Dawley rats

Intraventricular cerebrospinal fluid temperature analysis using MR diffusion‐weighted imaging thermometry in Parkinson's disease patients, multiple system atrophy patients, and healthy subjects

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