1979
DOI: 10.2337/diab.28.12.1058
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Chronic Hyperinsulinemia in the Fetal Rhesus Monkey: Effects on Fetal Growth and Composition

Abstract: The delivery of 19 U of insulin a day for 21 days to the rhesus monkey fetus, coupled with the permeability properties of the placenta, has made it possible to produce fetal hyperinsulinemia in the presence of euglycemia. Fetal plasma insulin concentrations of 3525 /All/ml were attained with no apparent effects on the mother. In fetal macrosomia, a 34% increase in body weight was observed above the expected weight for gestational age (466 vs. 348 g). Relative organomegaly, matched for gestational age of fetal … Show more

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Cited by 202 publications
(89 citation statements)
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“…Insulin had no direct action at physiological concentrations on the uptake of either ['Hlthymidine or ["S]sulfate by fetal rat costal cartilage in vitro (2,18). The administration of pharmacological concentrations of insulin to the fetal rat and monkey led to enhanced body growth (29,30), but this may have been mediated by an increase in circulating somatomedin since somatomedin activity was enhanced in the fetal rabbit and pig following treatment with insulin in utero (3 1, 32). In the postnatal rat, insulin was shown to stimulate somatomedin production directly from liver during perfusion and tissue slice incubation (33,34).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Insulin had no direct action at physiological concentrations on the uptake of either ['Hlthymidine or ["S]sulfate by fetal rat costal cartilage in vitro (2,18). The administration of pharmacological concentrations of insulin to the fetal rat and monkey led to enhanced body growth (29,30), but this may have been mediated by an increase in circulating somatomedin since somatomedin activity was enhanced in the fetal rabbit and pig following treatment with insulin in utero (3 1, 32). In the postnatal rat, insulin was shown to stimulate somatomedin production directly from liver during perfusion and tissue slice incubation (33,34).…”
Section: Discussionmentioning
confidence: 99%
“…Group 1. The mean gestational age was 33.5 wk (range, [28][29][30][31][32][33][34][35][36]. The mean birth weight was 2244 g (range, 12 .…”
Section: Methodsmentioning
confidence: 99%
“…(120) implanted osmotic minipumps containing insulin into monkey fetuses. Three weeks of pharmacological hyperinsulinemia resulted in a 34% increase in fetal body weight associated with enlargement of the heart.…”
Section: Insulin As a Fetal G R O W T H Factormentioning
confidence: 99%
“…Glukoz, beyin için primer metabolittir ve insülinin ise büyümeyi arttırıcı etkisi bilinmektedir 13 . Diyabetik rhesus maymunlarla yapıl-mış çalışmalarda, iç organlar, yağ dokusu ve tüm vü-cut ağırlığında önemli ölçüde artış saptanırken, beyin ağırlığında değişiklik saptanmamıştır 19,20 .…”
Section: Discussionunclassified