Chronic hyperprolactinemia and plasma lipids in women

Abstract

Plasma total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) were studied in 15 hyperprolactinemic women who had a prolactin (PRL) adenoma, in comparison to 15 age-matched control women. In the hyperprolactinemic group, plasma lipids were also correlated to age, excess body weight (EBW), plasma PRL, and estradiol-17 beta (E2). Plasma TC, TG, and LDL-C were similar in both hyperprolactinemic and control women, while plasma HDL-C was significantly lower (P less than 0.01) in the hyperprolactinemic group. The correlation study showed a significant negative correlation between HDL-C and EBW (r = -0.64; P less than 0.02) and a slightly significant positive correlation between TG and PRL (r = 0.54; P less than 0.05). The direct effect of PRL on plasma lipids is difficult to establish since many factors influencing lipid metabolism are altered during hyperprolactinemia.

Correlation between serum lipid profile and carotid intima-media thickness in Polycystic Ovarian Syndrome

“…Bonithon-Kopp et al (20) suggested a mean carotid IMT > 0.75 mm as a measure of subclinical atherosclerosis. In our study 16.67% of PCOS cases met the criteria against none in the control group. 10% of PCOS women approached (0.7 mm) this value.…”

“…We estimated serum TSH and Prolactin levels to rule out hypothyroidism and hyperprolactinemia as possible causes of dyslipidemia (15,16) cases. However as data of Table 2 shows, both of these hormones were within normal limits (TSH: 0.4 -6μIU/ml and Prolactin: 3 -23 ng/ml) and were not statistically different.…”

Effect of Chronic Cabergoline Treatment and Testosterone Replacement on Metabolism in Male Patients with Prolactinomas

“…Indeed, decreased HDL and increased CHOL and TG have been reported in patients with prolactinomas as compared to controls [75,76,77,78], and a direct correlation between lipid metabolism and PRL levels has been proposed [48]. PRL can directly act on adipose tissue and may be involved in the lipid metabolism of mature adipocytes [79,80,81,82].…”

Increased Lipid Levels Improves after Treatment with Cabergolin in Patients with Prolactinoma

“…Hyperprolactinemia leads to a reduction in estrogen levels by inhibiting the gonadotropin releasing hormone secretion, which may lead to an elevation in total and LDL-C and decrease in HDL-C [7]. Total C/ HDL C ratio, which has been approved as a new atherosclerotic risk marker for endothelial dysfunction in AACE 2012 Lipid and Atherosclerosis guidelines [20], were similar between three groups.…”

“…Ling et al demonstrated that, PRL increase triglyceride (TG) levels by reducing the lipoprotein lipase activity in adipose tissue [6]. Hyperprolactinaemia is associated with amenorrhoea and decreased estrogen concentration which may lead to the elevation in total cholesterol and low density lipoprotein cholesterol (LDL-C) and decrease in high density lipoprotein cholesterol (HDL-C) [7]. The aim of present study was to evaluate the metabolic parameters in non obese patients with prolactinoma and effect of cabergolin treatment on this parameters.…”