Chronic idiopathic urticaria: infiltrating cells and related cytokines in autologous serum-induced wheals

Caproni, Marzia; Giomi, Barbara; Volpi, Walter; Melani, Lucilla; Schincaglia, Emiliano; Macchia, Donatella; Manfredi, Mariangela; A, D'agata; Fabbri, Paolo

doi:10.1016/j.clim.2004.10.007

Cited by 117 publications

(134 citation statements)

References 37 publications

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“…Among chemokines, CCL5/RANTES is a potent chemoattractant protein for T cells, eosinophils, and monocytes [4] and CXCL8/IL-8 is the main chemoattractant factor for neutrophils [5]. An involvement of chemokines in the pathogenesis of CSU has been suggested by immunological studies conducted on skin biopsies [6,7], sera [8,9,10,11], and purified peripheral blood mononuclear cells [10]. In addition, an important role for CCL5/RANTES, CCL2/MCP-1, and CXCL8/IL-8 in histamine and serotonin release by mast cells has been described [12].…”

Section: Introductionmentioning

confidence: 99%

CCL5/RANTES, sVCAM-1, and sICAM-1 in Chronic Spontaneous Urticaria

Puxeddu¹,

Panza²,

Pratesi³

et al. 2013

Int Arch Allergy Immunol

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Background: Chronic urticaria (CU) is a common disease characterized by recurrent itchy wheals and/or angioedema for more than 6 weeks. We aimed to investigate the potential involvement of chemotactic mediators and soluble adhesion molecules as markers of endothelial dysfunction in the pathogenesis of chronic spontaneous urticaria (CSU). The potential relevance of these soluble mediators in the evaluation of disease activity was also investigated. Methods: We measured the levels of CCL5/RANTES, CXCL8/IL-8, sVCAM-1, and sICAM-1 in the sera of 87 patients with CSU and 61 normal healthy subjects (NHS) using ELISA assays. According to the results of autologous serum skin tests (ASST), CSU patients were classified into ASST-positive and ASST-negative subgroups. Furthermore, we investigated in 4 patients whether H₁-antihistamine therapy decreases sVCAM-1 and sICAM-1 levels. Results: We detected a significantly higher concentration of CCL5/RANTES (p < 0.0001) but not of CXCL8/IL-8 in CSU patients compared to NHS. The serum levels of sICAM-1 and sVCAM-1 were significantly increased in CSU patients compared to NHS (p = 0.0121 and p = 0.0043, respectively). No difference in chemokine or soluble adhesion molecule levels was detected between the ASST-positive and ASST-negative subgroups. A positive correlation was found between sICAM-1 and sVCAM-1 (p = 0.0022) but not between these and CCL5/RANTES. After H₁-antihistamine therapy, sVCAM-1 and sICAM-1 levels did not decrease in the 4 CSU patients tested. Conclusions: Our study suggests that CCL5/RANTES, sICAM-1, and sVCAM-1 play a potential role in the pathogenesis of CSU but they do not parallel disease activity and are not predictive of the response to H₁-antihistamine therapy.

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Section: Introductionmentioning

confidence: 99%

CCL5/RANTES, sVCAM-1, and sICAM-1 in Chronic Spontaneous Urticaria

Puxeddu¹,

Panza²,

Pratesi³

et al. 2013

Int Arch Allergy Immunol

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“…Human peripheral blood mononuclear lymphocytes were collected from the venous blood of the subjects by Ficoll-Paque gradient centrifugation. The lymphocytes were adjusted to a final concentration of 2x10 6 ̸ml in RPMI-1640 medium with 10% fetal bovine serum. The lymphocytes in the RPMI-1640 medium (100 µl, 2x10 6 ̸ml) were added to a 96-well culture plate, in which 10 µl of phytohemagglutinin (2 mg/ml) and differently diluted (0, 5, 10, 20, 40 and 80 µl/ml) of BCG-PSN (0.35 mg BCG polysaccharide with ≥30 µg/l nucleic acid) had been previously added.…”

Section: Methodsmentioning

confidence: 99%

“…However, in a substantial percentage of cases, the allergic trigger cannot be determined and the urticaria is classified as idiopathic (CIU), whereas ~35-40% of cases appear to be of autoimmune origin (4,5). The inflammatory response presenting with spontaneous wheals exhibits pro-inflammatory characteristics, involving a prominent role for lymphocytes with a mixed Th1/Th2 response (6). It was demonstrated that IL-10 production was elevated and IL-2 reduced in CIU patients compared to controls (7).…”

Section: Introductionmentioning

confidence: 99%

Effects of the polysaccharide nucleic acid fraction of bacillus Calmette-Guérin on the production of interleukin-2 and interleukin-10 in the peripheral blood lymphocytes of patients with chronic idiopathic urticaria

Cao

Niu

et al. 2013

Biomedical Reports

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“…It is named chronic idiopathic urticaria (CIU) in approximately 70% of the cases, since no cause can be identified. However, clinical-laboratory 4,5 and histopathological studies 6,7 have suggested that CU has autoimmune etiology at least in a subset of patients.…”

Section: Introductionmentioning

confidence: 99%

Autoimmune thyroid disease as a risk factor for angioedema in patients with chronic idiopathic urticaria: a case-control study

Missaka¹,

Penatti²,

Silvares

et al. 2012

Sao Paulo Med. J.

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CONTEXT AND OBJECTIVE: An association between chronic idiopathic urticaria (CIU) and autoimmune thyroid disease (ATD) has been reported. However, there have not been any reports on whether ATD raises the risk of angioedema, which is a more severe clinical presentation of CIU. Thus, the aim of the present study was to evaluate whether the risk of angioedema is increased in patients with CIU and ATD. DESIGN AND SETTING: Case-control study including 115 patients with CIU at a tertiary public institution. METHODS:The patients were evaluated with regard to occurrence of angioedema and presence of ATD, hypothyroidism or hyperthyroidism. RESULTS: Angioedema was detected in 70 patients (60.9%).

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Chronic idiopathic urticaria: infiltrating cells and related cytokines in autologous serum-induced wheals

Cited by 117 publications

References 37 publications

CCL5/RANTES, sVCAM-1, and sICAM-1 in Chronic Spontaneous Urticaria

CCL5/RANTES, sVCAM-1, and sICAM-1 in Chronic Spontaneous Urticaria

Effects of the polysaccharide nucleic acid fraction of bacillus Calmette-Guérin on the production of interleukin-2 and interleukin-10 in the peripheral blood lymphocytes of patients with chronic idiopathic urticaria

Autoimmune thyroid disease as a risk factor for angioedema in patients with chronic idiopathic urticaria: a case-control study

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