Chronic infection with Helicobacter pylori does not provoke major systemic inflammation in healthy adults: results from a large population-based study

Brenner, Hermann; Berg, Gabriele; Fröhlich, Margit; Boeing, H.; Köenig, Wolfgang

doi:10.1016/s0021-9150(99)00210-5

Cited by 34 publications

(17 citation statements)

References 15 publications

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“…Parent et al [2] have been reported prevalence of HP is 56% in healthy individuals and there is not a significant relationship between HP infection and, lipid, haemostatic and inflammatory factors. Publications that support this work as well as [3], there are studies that report an association between HP infection, and ischemic heart disease, plasma fibrinogen, and some lipid parameters [4]. The changes in hemoglobin, white blood cell and platelet values may occur in acute and chronic infectious diseases.…”

Section: Introductionsupporting

confidence: 58%

Complete Blood Cell Parameters between Anti-HP IgG Antibody Positive and Negative Subjects

Noyan¹

2013

Turk J Bioch

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Section: Introductionsupporting

confidence: 58%

Complete Blood Cell Parameters between Anti-HP IgG Antibody Positive and Negative Subjects

Noyan¹

2013

Turk J Bioch

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“…However, we want to point out that several studies found no association between infection and CAD or question this concept (11,37,38). We believe that LBP has the advantage of serving as a sensitive marker for the presence of LPS in the bloodstream, and our study might stimulate further work regarding the role of infectious diseases for CAD.…”

Section: Discussionmentioning

confidence: 78%

Association of Lipopolysaccharide-Binding Protein and Coronary Artery Disease in Men

Lepper

Schümann

Triantafilou

et al. 2007

Journal of the American College of Cardiology

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“…For example, a strong study conducted by Brenner and cols (1999) involving more than 1.800 healthy subjects did not prove the relation between H. pylori, bacterial virulence and inflammation markers. Although it was observed an inverse relation between H. pylori infection and serum albumin, the bacteria presence was unrelated to C-reactive protein and the leukocyte count, regardless of CagA status (4) . Such result was also reported in several studies that showed no impact of H. pylori's infection in systemic markers of inflammation (13,15,36,38) .…”

mentioning

confidence: 73%

Lack of Association Between Helicobacter Pylori's Virulence and Increased Serum C-Reactive Protein Levels in Functional Dyspeptic Patients

Andreolla

Bona

Sander

et al. 2016

Arq. Gastroenterol.

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-Background -Recently, a great variety of studies aimed to investigate and even suggest Helicobacter pylori as an important key factor in gastrointestinal and non-gastrointestinal events development. The well-established relationship between bacterial virulence and increased risk for peptic ulcer or gastric carcinoma is not so clear when comparing inflammation markers alterations, such C-reactive protein, with the pathogen. Objective -The objective of this study was to evaluate the presence of H. pylori, bacterial virulence and C-reactive protein serum levels in individuals diagnosed with functional dyspepsia. Methods -Were prospectively included in this study 489 dyspeptic individuals. They fulfill Rome III clinical criteria for the diagnosis of functional dyspepsia with no organic disease at endoscopy. The bacterial infection was established by histology and urease rapid test. The levels of serum C-reactive protein were obtained by immunonefelometry and CagA status of H. pylori positive individuals was determined through an imunoenzimatic assay. Results -Prevalence rate of H. pylori was 66.3% and virulence factor CagA was detected in nearly 43% of positive samples. In addition, it has been noticed an association between Ilex paraguariensis (yerba maté) consumption and pathogen's prevalence. An important effect of bacterial infection on inflammation was only observed in gastric epithelium. Conclusion -No systemic response to the pathogen, measured through C-reactive protein levels, was observed, regardless of CagA status. Otherwise, the intake of yerba maté should be considered as a cultural factor possibly related to H. pylori's transmission. According to the recent reports, CagA positive strains can cause severe damage to the gastric epithelium, being related specially with increased levels of interleukin-8 (IL-8), gastroduodenal ulcers and gastric neoplasia occurrence (26,29,41) . In addition, this virulence factor has been associated with systemic inflammation, resulting in high serum C-reactive protein (CRP) levels and the bacteria presence being related to higher cardiovascular risks (21,37) . Some behaviors have been associated to the transmission of H. pylori. Studies have reported that several aspects can be related to incidence and prevalence rates like socioeconomic status, years of study, institutionalization practice or social habits (8,20) . In 2010, a Brazilian study has demonstrated an anti-H. pylori activity of plant extracts, like yerba maté tea (Ilex paraguariensis), but no association between bacteria prevalence and tea consumption has been previously described (6) . Andreolla HF, Bona LR, Sander GB, Mazzoleni LE, Tavares RG, Prolla JC. Lack of association between Helicobacter pylori's virulence and increased serum C-reactive protein levels in functional dyspeptic patients HEADINGS - 50Arq Gastroenterol v. 53 no. 1 -jan./mar. 2016All H. pylori's infected people present histological gastritis. Moreover, the bacteria, classified as type I carcinogen (32) , has been associated with the...

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Chronic infection with Helicobacter pylori does not provoke major systemic inflammation in healthy adults: results from a large population-based study

Cited by 34 publications

References 15 publications

Complete Blood Cell Parameters between Anti-HP IgG Antibody Positive and Negative Subjects

Complete Blood Cell Parameters between Anti-HP IgG Antibody Positive and Negative Subjects

Association of Lipopolysaccharide-Binding Protein and Coronary Artery Disease in Men

Lack of Association Between Helicobacter Pylori's Virulence and Increased Serum C-Reactive Protein Levels in Functional Dyspeptic Patients

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