Chronic Inflammation and Cancer: The Role of Endothelial Dysfunction and Vascular Inflammation

Malhab, Lara J Bou; Saber-Ayad, Maha; Al-Hakm, Ranyah; Nair, Vidhya A; Paliogiannis, Panagiotis; Pintus, Gianfranco; Abdel‐Rahman, Wael M.

doi:10.2174/1381612827666210303143442

Cited by 28 publications

(14 citation statements)

References 127 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been confirmed that chronic inflammation is an important cause of many malignant tumors, but its effect on the occurrence and development of breast cancer is still poorly understood (47). A variety of chronic inflammatory factors have been found to increase the risk of breast cancer, suggesting that chronic inflammation may play a role in the initiation and development of breast cancer (13).…”

Section: Discussionmentioning

confidence: 99%

The potential effects and mechanisms of breast inflammatory lesions on the occurrence and development of breast cancer

et al. 2022

View full text Add to dashboard Cite

Breast cancer as the most common cancer in women has become the leading cause of cancer death for women. Although many inflammatory factors increase the risk of breast cancer, there are very few studies on the mechanisms by which inflammation affects the initiation and progression of breast cancer. Here, we profiled and compared the transcriptome of normal tissues, inflammatory breast tissues, benign breast tumors, and malignant breast tumors. To find key regulatory factors, a protein interaction network between characteristic modules in inflammatory lesions and ER-negative (ER−) breast cancer was constructed and inflammation-cancer interface genes were identified. We found that the transcriptional profile of inflammatory breast tissues was similar with ER− malignant tumors, featured with low ER expression levels and similar immune signaling pathway activation. Through comprehensive protein network analysis, we identified the interface genes and chemokine signaling pathway that have the potential to promote inflammatory cancer transformation. These interface genes could be used as a risk factor to provide a certain basis for the clinical early detection and treatment of breast cancer. This is the first study to explore the association between breast inflammatory lesions and breast cancer at the transcriptome level. Our inflammation data and research results provide a basis for future inflammation-cancer transformation analysis.

show abstract

Section: Discussionmentioning

confidence: 99%

The potential effects and mechanisms of breast inflammatory lesions on the occurrence and development of breast cancer

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Inflammation plays a critical pathophysiological role in a wide range of pathological states, including cancer, diabetes, obesity, and neurodegenerative diseases ( Furman et al, 2019 ; Fois et al, 2020 ; Malhab et al, 2021 ). A significant body of research has provided strong evidence that resveratrol has anti-inflammatory properties by targeting transcription factors such as NF-kB and AP-1, and the gene COX-2 ( Meng et al, 2021 ).…”

Section: Inflammatory Statesmentioning

confidence: 99%

Disease-Associated Regulation of Non-Coding RNAs by Resveratrol: Molecular Insights and Therapeutic Applications

Giordo

Wehbe

Posadino

et al. 2022

Front. Cell Dev. Biol.

Self Cite

View full text Add to dashboard Cite

There have been significant advances, particularly over the last 20 years, in the identification of non-coding RNAs (ncRNAs) and their pathophysiological role in a wide range of disease states, particularly cancer and other chronic conditions characterized by excess inflammation and oxidative stress such as atherosclerosis, diabetes, obesity, multiple sclerosis, osteoporosis, liver and lung fibrosis. Such discoveries have potential therapeutic implications as a better understanding of the molecular mechanisms underpinning the effects of ncRNAs on critical homeostatic control mechanisms and biochemical pathways might lead to the identification of novel druggable targets. In this context, increasing evidence suggests that several natural compounds can target ncRNAs at different levels and, consequently, influence processes involved in the onset and progression of disease states. The natural phenol resveratrol has been extensively studied for therapeutic purposes in view of its established anti-inflammatory and antioxidant effects, particularly in disease states such as cancer and cardiovascular disease that are associated with human aging. However, increasing in vitro and in vivo evidence also suggests that resveratrol can directly target various ncRNAs and that this mediates, at least in part, its potential therapeutic effects. This review critically appraises the available evidence regarding the resveratrol-mediated modulation of different ncRNAs in a wide range of disease states characterized by a pro-inflammatory state and oxidative stress, the potential therapeutic applications, and future research directions.

show abstract

“…It is also a disease of autoimmune aseptic inflammation. Research shows that chronic inflammation is an indispensable participant in cancer development (3)(4)(5)(6)(7). Therefore, more and more research institutes begin to study the relationship between HT and cancer.…”

Section: Introductionmentioning

confidence: 99%

Cancer Risk in Hashimoto’s Thyroiditis: a Systematic Review and Meta-Analysis

Wang

Liang

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

ObjectiveResearch data suggest that patients with Hashimoto’s thyroiditis may increase the risk of cancer. However, existing research is inconsistent with this view. Therefore, to investigate the effect of Hashimoto’s thyroiditis on the risk of developing cancer, we conducted this study.MethodsWe searched the PubMed and Embase databases from database establishment until March 2022. After rigorous literature screening by two authors, 23 studies that met the inclusion criteria were identified, and the required data were independently extracted.ResultsWe retrieved 3591 records, and after the screening, 11 case-control studies and 12 cohort studies were included in the analysis. Data analysis suggested that patients with Hashimoto’s thyroiditis had an increased risk of developing breast cancer, urogenital cancer, digestive organs cancer, hematologic cancer, and a low risk of respiratory cancers.ConclusionsThis systematic review and meta-analysis showed that patients with HT may have a significantly increased risk of thyroid cancer, breast cancers, lung cancer, digestive system cancer, urogenital cancers, blood cancers, and prolactinoma people without HT.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD 42022320741.

show abstract

Chronic Inflammation and Cancer: The Role of Endothelial Dysfunction and Vascular Inflammation

Cited by 28 publications

References 127 publications

The potential effects and mechanisms of breast inflammatory lesions on the occurrence and development of breast cancer

The potential effects and mechanisms of breast inflammatory lesions on the occurrence and development of breast cancer

Disease-Associated Regulation of Non-Coding RNAs by Resveratrol: Molecular Insights and Therapeutic Applications

Cancer Risk in Hashimoto’s Thyroiditis: a Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About