Chronic Inflammation and Iron Metabolism

The Role of Nutrition in Brain Development: The Golden Opportunity of the “First 1000 Days”

“…These include infection and inflammation, which significantly affect how protein, zinc and iron are processed. In the case of iron, infection increases levels of hepcidin, which reduces iron absorption, sequesters iron in the reticulo-endothelial system, and results in functional iron deficiency 57 .…”

Hepcidin correlates with interleukin-1β and interleukin-6 but not iron deficiency in children with Helicobacter pylori infection

“…21,24 H. pyloriemediated ID is characterized by decreased serum iron concentrations and low iron saturations, but not always decreased serum ferritin concentrations. 19,20 Increased serum ferritin levels in chronic inflammation are considered to reflect the process of iron sequestration in the reticuloendothelial system. In our study, H. pylori seropositive children with low-serum hepcidin but a high prevalence of ID inferred that hepcidin might not be the main initiator of ID development and might be the result of feedback regulation.…”

“…H. pyloriemediated ID is characterized by decreased serum iron concentration and iron saturation, but not always by decreased serum ferritin concentration. 19,20 Increased serum ferritin levels with chronic inflammation are considered to reflect the process of iron sequestration in the reticuloendothelial system. Therefore, children with iron saturation less than 15% were considered to have ID in this study.…”

<p>BCc1 Nanomedicine Therapeutic Effects in Streptozotocin and High-Fat Diet Induced Diabetic Kidney Disease</p>

“…4 In recent decades, numerous studies have focused on the critical role of iron metabolism disruption (with or without iron overload) in diabetes, CKD, cancer and other chronic diseases initiation, progression and development. [5][6][7] Although iron as a trace element has vital roles in the physiology of human beings, it is a redox-active element, so a vicious cycle of iron dis-homeostasis, inflammation and oxidative stress is formed mostly through free radicals induced by iron in chronic diseases, [8][9][10][11][12] and therefore manipulation of iron homeostasis in chronic diseases, especially in DKD, is evaluated in dozens of studies using iron chelators to assess their impacts. [13][14][15][16][17] In fact, iron chelation in these situations means iron re-distribution, not iron excretion.…”