Chronic inflammation: Cellular events

Whitehouse, M. W.

doi:10.1007/bf01972185

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2009

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Cited by 3 publications

(1 citation statement)

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“…A metal compound may be responsible for antiinflammatory activity of those agents, which have clinical use [59][60][61][62][63]. 5(2 0 -Hydroxyphenyl)-3(4-x-phenyl)pyrazolinates of copper, which have not been generally recognized as possible active metabolites, may be responsible for anti-inflammatory activity of clinically used antiinflammatory agents.…”

Section: Compoundmentioning

confidence: 99%

Synthesis, spectroscopic, antimicrobial and anti-inflammatory studies of 5(2′-hydroxyphenyl)-3-(4-x-phenyl)pyrazolinates of copper(II) and their addition complexes with donor ligands

Sharma¹,

Sharma

Dubey

et al. 2009

Journal of Coordination Chemistry

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Section: Compoundmentioning

confidence: 99%

Synthesis, spectroscopic, antimicrobial and anti-inflammatory studies of 5(2′-hydroxyphenyl)-3-(4-x-phenyl)pyrazolinates of copper(II) and their addition complexes with donor ligands

Sharma¹,

Sharma

Dubey

et al. 2009

Journal of Coordination Chemistry

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Lipophilic copper(II) formulations: Some correlations between their composition and anti-inflammatory/anti-arthritic activity when applied to the skin of rats

1982

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Copper complexes of phenols related to salicylic acid were prepared in DMSO and applied to the shaved dorsal skin of rats. The following activities were assayed: (i) suppression of the carrageenan or hydroxylapatite paw oedemas; (ii) reduction of chronic inflammation in established adjuvant arthritis; (iii) local skin toxicity. Cu(II) was an essential component. Some limited structure-activity correlations were made among alternative cupriphores. DMSO solutions of copper complexes were more potent than their solutions in ethanol. Glycerol was a beneficial additive. Reducing the acidity of some copper salicylate formulations also reduced their potency. Niflumic acid and phenylbutazone were effective non-salicylate transcutaneous cupriphores.

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In vitro antioxidant properties of potential biotransformaton products of salicylate, sulphasalazine and aminodypyrine

Betts

Whitehouse

Cleland

et al. 1985

Journal of Free Radicals in Biology & Medicine

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Chronic inflammation: Cellular events

Cited by 3 publications

References 8 publications

Synthesis, spectroscopic, antimicrobial and anti-inflammatory studies of 5(2′-hydroxyphenyl)-3-(4-x-phenyl)pyrazolinates of copper(II) and their addition complexes with donor ligands

Synthesis, spectroscopic, antimicrobial and anti-inflammatory studies of 5(2′-hydroxyphenyl)-3-(4-x-phenyl)pyrazolinates of copper(II) and their addition complexes with donor ligands

Lipophilic copper(II) formulations: Some correlations between their composition and anti-inflammatory/anti-arthritic activity when applied to the skin of rats

In vitro antioxidant properties of potential biotransformaton products of salicylate, sulphasalazine and aminodypyrine

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