Chronic Ingestion of Uranium in Drinking Water: A Study of Kidney Bioeffects in Humans

Zamora, M. Limson; Tracy, B.L.; Zielinski, Jan M.; Meyerhof, Dorothy; Moss, Michael A.

doi:10.1006/toxs.1998.2426

Cited by 93 publications

(72 citation statements)

References 35 publications

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“…At lower levels of exposure, though adverse health effects are not immediately observed, there is a possibility of their late appearance [76]. Soluble uranium is a potential radiotoxic and the population may be exposed to even low levels through inhalation and from drinking water [77,78]. Uranium can mix into the drinking water supply during mining processes [76].…”

Section: Discussionmentioning

confidence: 99%

Impacts of Terrestrial Ionizing Radiation on the Hematopoietic System

Shahid¹,

Chauhdry²,

Mahmood³

et al. 2015

Pol. J. Environ. Stud.

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Section: Discussionmentioning

confidence: 99%

Impacts of Terrestrial Ionizing Radiation on the Hematopoietic System

Shahid¹,

Chauhdry²,

Mahmood³

et al. 2015

Pol. J. Environ. Stud.

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“…The toxic effects of uranium compounds have been extensively studied in the kidney (Guglielmotti et al, 1989;Kurttio et al, 2002) and bones of laboratory animals (Larivière et al, 2007). The chemical toxicity effects on the human kidney by chronic ingestion of uranium through drinking water in the range of 0.004 to 9 µg.L -1 per body weight per day may produce interference with kidney functions (Zamora et al, 1998). In a more recent study on humans by Kurttio et al (2005), nephrotoxic effects of uranium in drinking water were found even for low concentrations -without a clear threshold.…”

Section: Risk From the Intake Of Uranium Through Ingestionmentioning

confidence: 98%

Risk assessment (chemical and radiological) due to intake of uranium through the ingestion of drinking water around two proposed uranium mining areas, Jharkhan d, India

Giri

Jha

2012

Radioprotection

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Uranium is known for both chemical and radiological toxicity. East Singhbhum isknown for uranium mining, and radionuclides can be expected in its groundwater. Groundwater was collected around two proposed sites of Bagjata and Banduhurang and analysed for U(nat). The study reveals that the U(nat) varied from <0.5-11.2 and <0.5-27.5 µg.L -1 for the Bagjata and Banduhurang mining areas, respectively. The excess lifetime cancer risk due to the consumption of uranium in water was calculated to be in the range of 8.81 × 10 -6 to 4.34 × 10 -5 and 3.36 × 10 -6 to 9.55 × 10 -5 for the two study areas, which are within the acceptable cancer risk value of 1 × 10 -4 . However, the risk at a few locations is very close to the threshold value. The chemical risk evaluated by the hazard quotient was found to be within 0.05-0.23 and 0.02-0.6 for the two study areas and did not exceed the limit of 1. Thus, the concentration of U(nat) in the groundwater presently does not pose any serious threat to local people but must be monitored periodically and adequate actions must be taken in the few areas with elevated levels of uranium in the groundwater.

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“…Uranium in the bloodstream is filtered by and deposited in the kidneys, where it targets the proximal tubules [42]. Uranium exposure has been found to be positively associated with cytotoxicity biomarkers: increases in urinary albumin [8], glucose and calcium [2], β2-microglobulin and alkaline phosphatase [6]. Absorbed uranium not excreted via urine, accumulates primarily in the skeleton and kidney [4,43].…”

Section: Uraniummentioning

confidence: 99%

“…However, most of the key studies of health effects from drinking uranium contaminated water have been conducted in other countries [4,[6][7][8]. In the United States, naturally occurring elevated uranium in groundwater has been identified as a widespread issue in Western states, as well as in scattered locations in Eastern states [2,9].…”

Section: Introductionmentioning

confidence: 99%