Chronic intermittent nicotine treatment dose-dependently alters serotonergic neurons response to citalopram in the rat

Touiki, Khalid; Rat, Pascal; Arib, Ouafa; Molimard, R; Chait, Abderrahman; Beaurepaire, Renaud de

doi:10.1016/j.pbb.2008.01.005

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…As with dopamine and norepinephrine, animal studies have shown that most drugs of abuse acutely increase serotonin in both cortical and subcortical areas (Tao and Auerbach, 1995;Selim and Bradberry, 1996;Teneud et al, 1996;Singer et al, 2004;Pum et al, 2007), though cannabis is a notable exception that actually decreases serotonergic activity (Sano et al, 2008). The effects of chronic drug use on serotonin are also fairly consistent across classes, with chronic cocaine, alcohol and morphine causing long-term decreases (Parsons et al, 1995;McBride et al, 2004;Goeldner et al, 2011), but no clear effect of either chronic amphetamine or nicotine (Touiki et al, 2008;Barr et al, 2013). Selective serotonin reuptake inhibitors are generally not effective for SUDs (Kranzler et al, 1995;Lima et al, 2003;Hughes et al, 2014), though some studies indicate that antidepressants for alcohol use disorder may improve outcomes for some patients and worsen outcomes for others depending on family history and pattern of alcohol use (Pettinati et al, 2000;Chick et al, 2004;Kranzler et al, 2012).…”

Section: Overlapping Effects Of Trauma and Drugs On Neuronal And Endomentioning

confidence: 99%

Mechanisms of Shared Vulnerability to Post-traumatic Stress Disorder and Substance Use Disorders

Maria-Rios

Morrow

2020

Front. Behav. Neurosci.

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Psychoactive substance use is a nearly universal human behavior, but a significant minority of people who use addictive substances will go on to develop an addictive disorder. Similarly, though ∼90% of people experience traumatic events in their lifetime, only ∼10% ever develop post-traumatic stress disorder (PTSD). Substance use disorders (SUD) and PTSD are highly comorbid, occurring in the same individual far more often than would be predicted by chance given the respective prevalence of each disorder. Some possible reasons that have been proposed for the relationship between PTSD and SUD are self-medication of anxiety with drugs or alcohol, increased exposure to traumatic events due to activities involved in acquiring illegal substances, or addictive substances altering the brain's stress response systems to make users more vulnerable to PTSD. Yet another possibility is that some people have an intrinsic vulnerability that predisposes them to both PTSD and SUD. In this review, we integrate clinical and animal data to explore these possible etiological links between SUD and PTSD, with an emphasis on interactions between dopaminergic, adrenocorticotropic, GABAergic, and glutamatergic neurobehavioral mechanisms that underlie different emotional learning styles.

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Section: Overlapping Effects Of Trauma and Drugs On Neuronal And Endomentioning

confidence: 99%

Mechanisms of Shared Vulnerability to Post-traumatic Stress Disorder and Substance Use Disorders

Maria-Rios

Morrow

2020

Front. Behav. Neurosci.

View full text Add to dashboard Cite

show abstract

“…CRF, endogenous opioids, and orexins). For details on the relevance of these diverse actions of NIC in various brain functions and in the development and maintenance of NIC dependence, (see De Biasi and Salas, 2008;Di Matteo et al, 2007;Touiki et al, 2007Touiki et al, , 2008Seth et al, 2002;Galindo-Charles et al, 2008;Rossi et al, 2005a,b;Grilli et al, 2005;Markou, 2007Markou, , 2008Liechti and Markou, 2008;Kenny et al, 2009;Hahn and Stolerman, 2005;Erhardt et al, 2000;George et al, 2007;Xue and Domino, 2008;Chen et al, 2008b;Merritt et al, 2008;Pasumarthi and Fadel, 2008).…”

Section: Relevance Of Dopamine In Nicotine Addictionmentioning

confidence: 99%