Chronic kidney disease‐associated pruritus in patients undergoing hemodialysis: Xerosis and topical therapy

Abstract

Chronic kidney disease‐associated pruritus (CKD‐aP) is a common and distressing symptom for patients with CKD and a difficult challenge for nephrologists and dermatologists. Recent results showed the multifactorial nature of the pathophysiology, and therapeutic trials were only successful in certain subsets of patients. The clinical manifestations are varied, with xerosis being the most common dermatological manifestation and correlated with the intensity of CKD‐aP. A better understanding of the pathophysiology of xerosis in CKD‐aP and appropriate topical treatment could correct xerosis to reduce the intensity of CKD‐aP and improve the patient's quality of life.

Data independent acquisition reveals in-depth serum proteome changes in uremic pruritus

“…Uremic toxins, skin barrier impairments, neurogenic pathways, immune dysregulation, and other factors are thought to contribute to UP( Narita et al, 2008 ; Ko et al, 2023 ). Studies have indicated that low skin moisture in dialysis patients may be one of the contributing factors to induce pruritus ( Morton et al, 1996 ; Ko et al, 2023 ; Krismi et al, 2023 ). Moreover, the significant increase in the number of dermal mast cells in UP patients is also considered as an important factor promoting skin itching ( Robertson et al, 2016 ; Simonsen et al, 2017 ).…”