Chronic kidney disease‐associated pruritus (CKD‐aP) is a common and distressing symptom for patients with CKD and a difficult challenge for nephrologists and dermatologists. Recent results showed the multifactorial nature of the pathophysiology, and therapeutic trials were only successful in certain subsets of patients. The clinical manifestations are varied, with xerosis being the most common dermatological manifestation and correlated with the intensity of CKD‐aP. A better understanding of the pathophysiology of xerosis in CKD‐aP and appropriate topical treatment could correct xerosis to reduce the intensity of CKD‐aP and improve the patient's quality of life.