Chronic kidney disease‐related physical frailty and cognitive impairment: a systemic review

Shen, Zhiyuan; Ruan, Qingwei; Yu, Zhuowei; Sun, Zhongquan

doi:10.1111/ggi.12758

Cited by 66 publications

(56 citation statements)

References 161 publications

(317 reference statements)

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“…Several reviews have been published on the well‐established association of chronic kidney disease and cognitive dysfunction; yet, they have focused on advanced kidney damage stages . Presence of microalbuminuria, mainly attributed to glomerular leakage, corresponds to an earlier subclinical time‐point in kidney disease progress, when eGFR may have not yet been affected .…”

Section: Discussionmentioning

confidence: 99%

Albuminuria in Association with Cognitive Function and Dementia: A Systematic Review and Meta‐Analysis

Georgakis

Dimitriou

Karalexi

et al. 2017

J American Geriatrics Society

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Section: Discussionmentioning

confidence: 99%

Albuminuria in Association with Cognitive Function and Dementia: A Systematic Review and Meta‐Analysis

Georgakis

Dimitriou

Karalexi

et al. 2017

J American Geriatrics Society

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“…3 One review suggested that CKD is a risk factor for cognitive impairment and frailty in older adults. 4 The incidence of frailty in patients with chronic kidney disease is higher than that in the general elderly population due to changes in protein metabolism, inflammation, oxidative stress, anemia and other reasons. 5 It has been pointed out that the incidence of frailty in the healthy elderly is about 11%, while the incidence of frailty in the elderly with CKD is about 6 times (up to 60%) as that in the healthy elderly.…”

Section: Introductionmentioning

confidence: 99%

<p>Main Risk Factors Related to Activities of Daily Living in Non-Dialysis Patients with Chronic Kidney Disease Stage 3–5: A Case–Control Study</p>

Chang¹,

Hou²,

Wang³

et al. 2020

CIA

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Introduction: Elderly people are at increased risk of falls, disability and death due to reduced functional reserve, decline in multiple systems functions, which affects their activities of daily living (ADL) and eventually develop into frailty. The ADL assessment is conducive to early detection to avoid further serious situations. Previous studies on patients' activities of daily living with chronic kidney disease (CKD) are mainly focused on dialysis patients. Little information is available on non-dialysis patients. Patients and Methods: A total of 303 elderly patients with CKD stage 3-5 who were admitted to our hospital were selected. ADL evaluation was performed on patients at admission, with Barthel index (BI) as the evaluation tool. They were divided into two groups based on BI (≥60 and <60). Demographic information, lifestyle and clinical profile were collected. The risk factors related to ADL were analyzed by univariate and multivariate models. Results: The data of 303 patients enrolled in this study were analyzed. The average age of patients was 84.48± 7.14 years and 62.05% were male. There were 88 patients (29.04%) in BI <60 group and 215 patients (70.96%) in the BI ≥60 group. The average age of subjects in the two groups was 87.47 ± 5.85 years and 83.26± 7.28 years, respectively. On univariate analysis, ADL impairment was associated with many factors, such as age, body mass index, blood lipid, heart rate, smoking history, Charlson comorbidity index (CCI), hemoglobin, serum albumin, BNP, eGFR, etc. Multivariate logistic regression showed that age (OR 1.08, 95% CI 1.00-1.17, P=0.0390), Charlson comorbidity index (OR 4.75, 95% CI 1.17-19.30, P=0.0295), and serum albumin (OR 0.80, 95% CI 0.70-0.92, P=0.0012) were the independent risk factors of ADL impairment. Conclusion: Decline of ADL in CKD patients was independently correlated with age, Charlson comorbidity index and serum albumin. ADL and its influential factors in the elderly CKD patients deserve further attention.

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“…A recent systematic review was performed looking at the relationship between CKD and physical frailty and cognitive impairment (38). They found clear evidence of a relationship between CKD and frailty and cognitive impairment.…”

Section: Sarcopeniamentioning

confidence: 99%

Wasting in Chronic Kidney Disease – a Complex Issue

Slee

Reid²

2018

JCSM Clinical Reports

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Chronic kidney disease (CKD) has become a global health burden and is associated with increased morbidity and mortality. In particular, wasting is highly prevalent in later stages of the illness with muscle loss being a common problem. The aetiology and progression of this wasting is complex and multiple states have been identified linked to wasting in CKD. These include: 'malnutrition', 'disease-related malnutrition', 'protein-energy wasting', 'cachexia', 'sarcopenia', 'frailty' and 'muscle wasting'. The purpose of this paper is to review these terms in the context of CKD. Common features include weight loss, loss of muscle mass and muscle function principally driven by CKD disease specific factors and inflammatory mediators. Disease-related malnutrition would appear to be a more appropriate term for CKD than malnutrition as it take in to consideration disease specific factors such as inflammation for example. Frailty is commonly associated with age-related decline in physiological function. Development of novel screening tools measuring across multiple domains of nutritional status, muscle and physical function may be useful in CKD. Research into potential treatments are currently underway with focus on multi-modal therapies including nutrition, resistance training and anabolic drugs such as myostatin blockade and selective androgen receptor modulators. A better understanding of different states and terms may help guide assessment and treatment opportunities for patients.

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Chronic kidney disease‐related physical frailty and cognitive impairment: a systemic review

Cited by 66 publications

References 161 publications

Albuminuria in Association with Cognitive Function and Dementia: A Systematic Review and Meta‐Analysis

Albuminuria in Association with Cognitive Function and Dementia: A Systematic Review and Meta‐Analysis

<p>Main Risk Factors Related to Activities of Daily Living in Non-Dialysis Patients with Chronic Kidney Disease Stage 3–5: A Case–Control Study</p>

Wasting in Chronic Kidney Disease – a Complex Issue

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