Chronic Kidney Disease

Workeneh, Biruh

doi:10.1016/b978-0-12-381462-3.00090-2

Cited by 2 publications

(2 citation statements)

References 745 publications

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“…In a recent study, we evaluated l-tyrosine content as an AOPP marker; this amino acid residue may oxidize, thereby changing the structure of proteins and causing them to cross-link, aggregate, or fragment under oxidative stress conditions such as AOPP reaction [ 56 ]. Compared to group I, three dosages of N. nucifera extract did not contribute to any differences.…”

Section: Discussionmentioning

confidence: 99%

Effects of Nelumbo nucifera Gaertn. Petal Tea Extract on Hepatotoxicity and Oxidative Stress Induced by Mancozeb in Rat Model

Nuchniyom,

Intui,

Laoung-on

et al. 2023

Toxics

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Mancozeb (Mz) is one of the most widely used pesticides that has been reported to cause adverse human health risks. White Nelumbo nucifera (N. nucifera) petals have therapeutic properties to prevent toxicity. Hence, this study attempted to determine the effects of N. nucifera extract on hepatotoxicity and oxidative stress in mancozeb-treated rats. Seventy-two male rats were divided into nine groups and designed with a control; N. nucifera extract was administered at the doses of 0.55, 1.1, and 2.2 mg/kg bw/day, Mz was administered at 500 mg/kg bw/day, and the co-treatment groups (N. nucifera and Mz) were administered 0.55, 1.1, and 2.2 mg/kg bw/day of N. nucifera followed by administering Mz 500 mg/kg bw/day daily for 30 days. The results showed that all doses of N. nucifera extract did not induce hepatic toxicity and could suppress the toxicity of mancozeb by increasing body weight gain and decreasing relative liver weight, lobular inflammation, and total injury score. The combination treatment also decreased the molecular markers of oxidative stress (2-hydroxybutyric acid, 4-hydroxynonenal, l-tyrosine, pentosidine, and N6-carboxymethyllysine). Furthermore, the reduced glutathione and oxidized glutathione contents were adjusted close to the normal level. Therefore, N. nucifera extract is a natural antioxidant supplement that could decrease the toxicity of mancozeb and can be safely consumed.

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Section: Discussionmentioning

confidence: 99%

Effects of Nelumbo nucifera Gaertn. Petal Tea Extract on Hepatotoxicity and Oxidative Stress Induced by Mancozeb in Rat Model

Nuchniyom,

Intui,

Laoung-on

et al. 2023

Toxics

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show abstract

“…The accumulation of uremic toxins within the renal system may be also attributed to damaged gastrointestinal mucosa by altered microbiota that facilitates an elevated permeability [ 11 ]. Disruption of intestinal permeability can lead to the alteration of intercellular junction proteins like claudin-1, occludin, cingulin, and zonula occluden-1.…”

Section: Introduction: Gut Microbiota Uremic Toxins Definition and Li...mentioning

confidence: 99%

Biotics (Pre-, Pro-, Post-) and Uremic Toxicity: Implications, Mechanisms, and Possible Therapies

Mitrea,

Medeleanu,

Pop

et al. 2023

Toxins

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In recent years, more scientific data have pointed out the close connection between intestinal microbial community, nutritional habits, lifestyle, and the appearance of various affections located at certain anatomical systems. Gut dysbiosis enhances the formation and accumulation of specific metabolites with toxic potential that induce the appearance of kidney-associated illnesses. Intestinal microbes are involved in the degradation of food, drugs, or other ingested products that lead to the formation of various metabolites that end up in renal tissue. Over the last few years, the possibilities of modulating the gut microbiota for the biosynthesis of targeted compounds with bioactive properties for reducing the risk of chronic illness development were investigated. In this regard, the present narrative review provides an overview of the scientific literature across the last decade considering the relationship between bioactive compounds, pre-, pro-, and post-biotics, uremic toxicity, and kidney-associated affections, and the possibility of alleviating the accumulation and the negative effects of uremic toxins into the renal system.

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Chronic Kidney Disease

Cited by 2 publications

References 745 publications

Effects of Nelumbo nucifera Gaertn. Petal Tea Extract on Hepatotoxicity and Oxidative Stress Induced by Mancozeb in Rat Model

Effects of Nelumbo nucifera Gaertn. Petal Tea Extract on Hepatotoxicity and Oxidative Stress Induced by Mancozeb in Rat Model

Biotics (Pre-, Pro-, Post-) and Uremic Toxicity: Implications, Mechanisms, and Possible Therapies

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