Chronic liver injury in mice promotes impairment of skin barrier functionviatumor necrosis factor-alpha

Yokoyama, S.; Hiramoto, Keiichi; Koyama, Mayu; Ooi, Kazuya

doi:10.3109/15569527.2015.1076433

Cited by 11 publications

(8 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have suggested mechanisms such as increased proinflammatory cytokines, eg, increased production of tumor necrosis factor -α (TNF-α) from peripheral blood monocytes and macrophages, and increased lymphocyte proliferation and activation, caused by alcohol 11. Alcohol-induced liver injury in mice resulted in an impairment of skin barrier function, possibly mediated via plasma TNF-α 12. Alcohol may also have an impact on the number and function of murine epidermal T cells 13.…”

Section: General Effects Of Alcoholmentioning

confidence: 99%

Psoriasis and alcohol

Svanstrom¹,

Lonne-Rahm²,

Nordlind³

2019

PTT

View full text Add to dashboard Cite

Psoriasis is a chronic inflammatory skin disease that may be triggered or worsened by several factors, including alcohol. A higher than average alcohol consumption is common among individuals with psoriasis. Neurobiological signaling affected by alcohol intake includes a range of neurotransmitters, such as the dopaminergic, serotonergic, and tachykinergic systems, involved in reward and drug-seeking. These neurotransmitters may also have an impact on the inflammatory processes per se in psoriasis. Future therapy may, therefore, be targeted at neurotransmitter networks involved with both alcohol intake and the inflammatory processes.

show abstract

Section: General Effects Of Alcoholmentioning

confidence: 99%

Psoriasis and alcohol

Svanstrom¹,

Lonne-Rahm²,

Nordlind³

2019

PTT

View full text Add to dashboard Cite

show abstract

“…Experimental studies in mice have revealed that alcohol-induced liver injury can lead to damage of skin barrier unction, possibly mediated via plasma TNF-α [61], whereas it has also been shown that alcohol and can influence the number and function of epidermal T cells [62] and can reduce dendritic function in female mice [63]. Moreover, alcohol can influence migration of murine dermal dendritic cells to draining lymph nodes after sensitization [64].…”

Section: Discussionmentioning

confidence: 99%

Periodontal Status Indices and Risk of Psoriasis in a Greek Adult Population: A Case - Control Study

Chrysanthakopoulos¹,

Vryzaki²

2021

JDODT

View full text Add to dashboard Cite

Aim: The aim of the current study was to investigate the possible relationship between periodontal status indices and the risk for psoriasis development in a Greek adult population. Subjects and Methods: The study sample comprised 337 psoriasis patients-cases and 337 healthy individuals-controls between 40 to 69 years of age who referred by three dermatology and one dental private practice. Cases and controls completed a health medical and dental questionnaire and underwent an examination of their periodontal status that included the following parameters: Probing Pocket Depth (PPD), Clinical Attachment Loss (CAL), frequency of a regular/irregular annual dental follow-up, and number of missing teeth. Odds ratios (OR’s) and 95% Confidence Intervals (95% CI’s) were assessed using logistic regression model adjusted for possible confounders. Results: The multivariate regression analysis model showed that a higher BMI (p=0.009, OR= 3.154, 95% CI= 1.532-4.028), alcohol overconsumption (p= 0.012, OR= 2.024, 95% CI=1.445-3.435), moderate /severe CAL (p=0.047, 95% CI=2.112, 1.156-3.249), and a number of missing teeth more than four (p=0.027, OR=2.817, 95% CI= 1.267-3.872 and p= 0.016, OR=3.510, 95% CI= 1.350-4.145) were statistically significantly associated with risk for psoriasis development. Conclusion: Individuals with a higher BMI, excessive alcohol consumption, moderate/severe attachment loss and a number of missing teeth more than four were at significantly higher risk for developing psoriasis. Keywords: Periodontal disease; Psoriasis; Number of missing teeth; Risk factor.

show abstract

“…Moreover, the skin of ethanol-administrated hairless mice is characterized by attenuated skin hydration with significantly increased transepidermal water loss, up-regulated expression of TNF receptor 2 (TNFR2), decreased production of ceramide and type I collagen and increased plasma TNFα concentrations. In addition, anti-TNFα antibody treatment ameliorated the impaired skin barrier function in these mice [39]. Chronic ethanol feeding negatively affects both the number and the function of murine epidermal and dermal T cell subsets [40].…”

Section: Alcohol and The Immune Systemmentioning

confidence: 94%

Alcohol in Psoriasis—From Bench to Bedside

Szentkereszty-Kovács

Gáspár

Szegedi

et al. 2021

IJMS

View full text Add to dashboard Cite

Alcohol affects the symptoms, compliance and comorbidities as well as the safety and efficacy of treatments in psoriatic patients. In this review, we aim to summarize and link clinical observations with a molecular background, such as signaling pathways at the cellular level and genetic variations, and to provide an overview of how this knowledge could influence our treatment selection and patient management.

show abstract

Chronic liver injury in mice promotes impairment of skin barrier functionviatumor necrosis factor-alpha

Abstract: We propose a novel mechanism whereby plasma TNF-α, via TNFR2 alone or with TNFR1, plays an important role in skin barrier function during chronic liver disease in these mouse models.

Cited by 11 publications

References 34 publications

<p>Psoriasis and alcohol</p>

<p>Psoriasis and alcohol</p>

Periodontal Status Indices and Risk of Psoriasis in a Greek Adult Population: A Case - Control Study

Alcohol in Psoriasis—From Bench to Bedside

Contact Info

Product

Resources

About